What health professionals should know about omega-3 fatty acid supplements

South African Journal of Clinical Nutrition

Volumn 26, Issue 2, 2013, Pages 6-11

  Opperman, Maretha ^a  

^a Department of Agriculture and Food Science   (South Africa)

Author keywords

Bioavailability; Frequency of intake labelling; Omega 3 fatty acids; Supplements

Indexed keywords

COD LIVER OIL; CORN OIL; DOCOSAHEXAENOIC ACID; FISH OIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ICOSAPENTAENOIC ACID; KRILL OIL; LINOLENIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MENHADEN OIL; OLIVE OIL; OMEGA 3 ACID ETHYL ESTER; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; OMEGA 9 FATTY ACID; PHOSPHOLIPID; PLACEBO; SALMON OIL; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; BIOAVAILABILITY; BLEEDING TIME; BRAIN HEMORRHAGE; CHOLESTEROL BLOOD LEVEL; CONSUMER HEALTH INFORMATION; CONTROLLED CLINICAL TRIAL (TOPIC); DIET SUPPLEMENTATION; DIETARY REFERENCE INTAKE; DRUG MARKETING; EPISTAXIS; EXPIRATION DATE; FAT INTAKE; FISH; GOVERNMENT REGULATION; HEALTH PRACTITIONER; HUMAN; HYDROLYSIS; IMMUNITY; ISCHEMIC HEART DISEASE; LIPID PEROXIDATION; LOADING DRUG DOSE; MEDICAL SOCIETY; META ANALYSIS (TOPIC); NONHUMAN; PACKAGING; PERINATAL CARE; PHOSPHOLIPID BLOOD LEVEL; PLANT NUTRITION; PRODUCT SAFETY; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECOMMENDED DRUG DOSE; SIDE EFFECT; SOUTH AFRICA; SYSTEMATIC REVIEW (TOPIC); TRANSESTERIFICATION; TRIACYLGLYCEROL BLOOD LEVEL; TUNA; VULNERABLE POPULATION;

EID: 84884489734     PISSN: 16070658     EISSN: None     Source Type: Journal    
DOI: 10.1080/16070658.2013.11734444     Document Type: Article

References (38)

1. Burge G. Alpha-linolenic acid metabolism in men and women: nutritional and biological implications. Curr Opin Clin Nutr Metab Care. 2004;7(2):137-144.
2. Kris-Etherton PM, Hill AM. N-3 fatty acids: food or supplements? J Am Diet Assoc. 2008;108(7):1125-1130.
3. Calder PC. Fatty acids and inflammation: the cutting edge between food and pharma. Eur J Pharmacol. 2011;668 Suppl 1:S50-S58.
4. Calder PC. Fatty acids and immune function: relevance to inflammatory bowel diseases. Int Rev Immunol. 2009;28(6):506-534.
5. Holmes C, Butchart J. Systemic inflammation and Alzheimer's disease. Biochem Soc Trans. 2011;39(4):898-901.
6. Scientific Advisory Committee on Nutrition. Advice on fish consumption: benefits and risks. London: Scientific Adviosry Committee on Nutrition; 2004. c2012. Available from: http://www.sacn.gov.uk/pdfs/fics_sacn_advice_fish.pdf
7. Innis SM. Dietary n 3 fatty acids and the developing brain. Brain Res. 2008;1237:35-43.
8. Bloch MH, Qawasmi A. N-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and metaanalysis. J Am Acad Child Adolesc Psychiatry. 2011;50(10):991-1000.
9. Harris WS, Mozaffarian D, Rimm E, et al. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation. 2009;119(6):902-907.
10. Kris-Etherton PM, Innis S. American Dietetic Association, Dietitians of Canada. Position of the American Dietetic Association and Dietitians of Canada: dietary fatty acids. J Am Diet Assoc. 2007;107(9):1599-611.
11. Ferro-Luzzi A, James WPT. European diet and public health: the continuing challenge. Public Health Nutr. 2001;4(2A):275-292.
12. Graham I, Atar D, Borch-Johnsen K, et al. European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J. 2007;28(19):2375-2414.
13. International Society for the Study of Fatty Acids and Lipids. Recommendations for the intake of polyunsaturated fatty acids in healthy adults [homepage on the Internet]. 2004. c2012. Available from: http://www.issfal.org.uk/
14. Koletzko B, Cetin I, Brenna JT. For the Perinatal Lipid Intake Working Group. Consensus Statement. Dietary fat intakes for pregnant and lactating women. Br J Nutr. 2007;98(5):873-877.
15. Koletzko B, Larqué E, Demmelmair H. Placental transfer of long-chain polyunsaturated fatty acids (LC-PUFA). J Perinat Med. 2008;35 Suppl 1:S5-S11.
16. Opperman AM, Marais DW, Benadé AJS. Washout kinetics of eicosapentanoic and docosahexanoic acid from human plasma after supplementation with salmon oil. S Afr J Clin Nutr. 2010;29:S8.
17. Opperman M, Benade AJS. Analysis of the omega-3 fatty acid content of South African fish oil supplements: a follow-up study. Cardiovasc J Afr. 2013; in press.
18. Srinivasan VS. Bioavailability of nutrients: a practical approach to in vitro demonstration of the availability of nutrients in multivitamin-mineral combination products. S Afr J Clin Nutr. 2010;23(3).
19. Schuchardt JP, Neubronner J, Kressel G, et al. Moderate doses of EPA and DHA from reesterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: results from a six month randomized controlled trial. Prostaglandins Leukot Essent Fatty Acids. 2011;85(6):381-386.
20. Dyerberg J, Madsen P, Moller JM, et al. Bioavailability of marine n-3 fatty acid formulations. Prostaglandins Leukot Essent Fatty Acids. 2010;83(3):137-141.
21. Armenta RE, Vinatoru M, Burja AM, et al. Transesterification of fish oil to produce fatty acid ethyl esters using ultrasonic energy. J Am Oil Chem Sos. 2007;84:1045-1052.
22. Ikeda I, Sasaki E, Yasunami H, et al. Digestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol, free acid and ethyl ester in rats. Biochim Biophys Acta. 1995;1259(3):297-304.
23. Neubronner J, Schuchardt JP, Kressel G, et al. Enhanced increase of n-3 index in response to long-term n3-fatty acid supplementation from triacylglycerides vs. ethyl esters. Eur J Clin Nutr. 2011;65(2):247-254.
24. Piscitelli F, Carta G, Bisogno T, et al. Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice. Nutr Metab (Lond). 2011;8(1):51-67.
25. Maki KC, Reeves MS, Farmer M, et al. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr Res. 2009;29(9):609-615.
26. Ulven SM, Kirkhus B, Lamglait A, et al. Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. S Afr J Clin Nutr. 2010;23(3).
27. Benade AJS, Opperman AM, Marais DW. Disappearance of long chain omega-3 fatty acids from human red blood cells in vivo after supplementation with salmon oil. S Afr J Clin Nutr. 2010;29(3):S6.
28. Foodstuffs, Cosmetics and Disinfectants Amendment Act 39 of 2007. Notice No 248. Government Gazette No 30822. Pretoria: Government Printers; 2008.
29. Foodstuffs, Cosmetics and Disinfectants Act 54 of 1972. Notice No R 146, Government Gazette No 32975. Pretoria: Government Printers; 2010.
30. Opperman AM, Marais DW, Benadé AJS. Analysis of omega-3 fatty acid content of South African fish oil supplements. Cardiovasc J Afr. 2011;22(6):324-329.
31. Department of Health and Human Safety US Food and Drug Administration. Substances affirmed as generally recognized as safe: menhaden oil. US Environmental Protection Agency [homepage on the Internet]. 2005. c2012. Available from: http://www.epa.gov/ fedrgstr/EPA-IMPACT/2005/March/Day-23/i5641.htm
32. Lopez-Huertas E. The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials. Br J Nutr. 2012;107 Suppl 2:S185-S194.
33. Mori TA, Burke V, Puddey IB, et al. Purified eicsapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am J Clin Nutr. 2000;71(5):1085-1094.
34. Griffin MD, Sanders TA, Davies IG, et al. Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 years: the OPTILIP Study. Am J Clin Nutr. 2006;84(6):1290-1298.
35. Yoerger DM, Best CA, McQuillan BM, et al. Rapid fatty acid ethyl ester synthesis by porcine myocardium upon ethanol infusion into the left anterior descending coronary artery. Am J Pathol. 2006;168(5):1435-1442.
36. Alhomsi K, Selig M, Sustic T, et al. Induction of apoptosis and necrosis in human peripheral blood mononuclear cells by fatty acid ethyl esters. Alcohol Clin Exp Res. 2008;32(3):534-543.
37. Bearer CF, Gould S, Emerson R, et al. Fetal alcohol syndrome and fatty acid ethyl esters. Pediatr Res. 1992;31(5):492-495.
38. Saghir M, Werner J, Laposata M. Rapid in vivo hydrolysis of fatty acid ethyl esters, toxic nonoxidative ethanol metabolites. Am J Physiol. 1997;273(1 Pt 1):G184-G190.