A BCR-JAK2 fusion gene from ins(22;9)(q11;p13p24) in a patient with atypical chronic myeloid leukemia

Leukemia and Lymphoma

Volumn 54, Issue 10, 2013, Pages 2322-2324

  Xu, Yang ^a   Yin, Jia ^a   Pan, Jinlan ^a   Wu, Chunxiao ^a   Wang, Qinrong ^a   Yao, Hong ^a   Wu, Depei ^a   Chen, Suning ^a   Sun, Aining ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BREAKPOINT CLUSTER REGION PROTEIN; HYDROXYUREA; JANUS KINASE 2;

ADULT; ATYPICAL CHRONIC MYELOID LEUKEMIA; BONE MARROW BIOPSY; CASE REPORT; CHROMOSOME ANALYSIS; DIZZINESS; FATIGUE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; HUMAN; IMMUNOPHENOTYPING; KARYOTYPE; LETTER; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MONOCYTE; NEUTROPHIL COUNT; PALLOR; PHYSICAL EXAMINATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLENOMEGALY; THROMBOCYTE COUNT;

ADULT; BASE SEQUENCE; BONE MARROW; CHROMOSOME BREAKPOINTS; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 9; HUMANS; JANUS KINASE 2; KARYOTYPING; LEUKEMIA, MYELOID, CHRONIC, ATYPICAL, BCR-ABL NEGATIVE; MALE; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEINS C-BCR; TRANSLOCATION, GENETIC; TREATMENT OUTCOME;

EID: 84884483475     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.762648     Document Type: Letter

References (13)

1. Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes. Blood 2009; 114: 937-951.
2. Ihle JN, Nosaka T, Thierfelder W, et al. J aks and Stats in cytokine signaling. Stem Cells 1997; 15(Suppl. 1): 105-111.
3. Tefferi A. JAK and MPL mutations in myeloid malignancies. Leuk Lymphoma 2008; 49: 388-397.
4. Jones AV, Kreil S, Zoi K, et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood 2005; 106: 2162-2168.
5. Carron C, Cormier F, Janin A, et al. TEL-JAK2 transgenic mice develop T-cell leukemia. Blood 2000; 95: 3891-3899.
6. Nebral K, Denk D, Attarbaschi A, et al. Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia. Leukemia 2009; 23: 134-143.
7. Van Roosbroeck K, Cox L, Tousseyn T, et al. J AK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma. Blood 2011; 117: 4056-4064.
8. Griesinger F, Hennig H, Hillmer F, et al. A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia. Genes Chromosomes Cancer 2005; 44: 329-333.
9. Elnaggar M M, A gersborg S, Sahoo T, et al. BCR-JAK2 fusion as a result of a translocation (9;22)(p24;q11.2) in a patient with CML-like myeloproliferative disease. Mol Cytogenet 2012; 5: 23.
10. Lane SW, Fairbairn DJ, McCarthy C, et al. Leukaemia cutis in atypical chronic myeloid leukaemia with a t(9;22) (p24;q11.2) leading to BCR-JAK2 fusion. Br J Haematol 2008; 142: 503.
11. Cirmena G, Aliano S, Fugazza G, et al. A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia. Cancer Genet Cytogenet 2008; 183: 105-108.
12. Impera L, Lonoce A, Fanfulla D A, et al. Two alternatively spliced 5-BCR/3-JAK2 fusion transcripts in a myeloproliferative neoplasm with a three-way t(9;18;22)(p23;p11.3;q11.2) translocation. Cancer Genet 2011; 204: 512-515.
13. Cuesta-Dom í nguez Á, Ortega M, Ormaz á bal C, et al. Transforming and tumorigenic activity of JAK2 by fusion to BCR: Molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase. PLoS One 2012; 7: E32451.