Influence of Vitamin D-Related Gene Polymorphisms (CYP27B and VDR) on the Response to Interferon/Ribavirin Therapy in Chronic Hepatitis C

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  García Martín, Elena ^a   Agúndez, José A G ^a   Maestro, María L ^b   Suárez, Avelina ^b   Vidaurreta, Marta ^b   Martínez, Carmen ^a   Fernández Pérez, Cristina ^c   Ortega, Luis ^b   Ladero, José M ^c  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; PEGINTERFERON; RIBAVIRIN; VITAMIN D; VITAMIN D RECEPTOR;

ADULT; AGED; ALLELE; ANTIVIRAL THERAPY; AREA UNDER THE CURVE; ARTICLE; COHORT ANALYSIS; CYP27B 1260 GENE; DRUG RESPONSE; DRUG TREATMENT FAILURE; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; HAPLOTYPE; HEPATITIS C; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SINGLE NUCLEOTIDE POLYMORPHISM; VDR GENE;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ADULT; AGED; ANTIVIRAL AGENTS; BIOLOGICAL MARKERS; DNA, VIRAL; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RECEPTORS, CALCITRIOL; RIBAVIRIN; ROC CURVE; VIRAL LOAD; YOUNG ADULT;

EID: 84884481719     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074764     Document Type: Article

References (27)

1. Maekawa S, Sakamoto M, Miura M, Kadokura M, Sueki R, et al. (2012) Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection. Hepatology 56: 1611-1621. [PMID: 22577043].
2. Romero-Gómez M, Del Mar Viloria M, Andrade RJ, Salmerón J, Diago M, et al. (2005) Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Gastroenterology 128: 636-641. [PMID: 19845037].
3. Cuenca F, Fernández C, Devesa MJ, López-Alonso G, Mayol J, et al. (2010) Predictive baseline criteria of primary therapeutic failure in chronic hepatitis C genotype 1. Rev Esp Enferm Dig 102: 234-238. [PMID: 20486745].
4. Bikle D (2009). Nonclassic actions of vitamin D. J Clin Endocrinol Metab 94: 26-34. [PMID: 18854395].
5. Gutierrez JA, Parikh N, Branch AD (2011) Classical and emerging roles of vitamin D in hepatitis C virus infection. Sem Liver Dis 31: 387-398.[PMID: 22189978].
6. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, et al. (2012) The nonskeletal effects of vitamin D: an Endocrine Society Scientific Statement. Endocrinol Rev 33: 456-492. [PMID: 22596255].
7. Arteh J, Narra S, Nair S (2010) Prevalence of vitamin D deficiency in chronic liver disease. Dig Dis Sci 55: 513-520. [PMID: 19960254].
8. Fisher L, Fisher A (2007). Vitamin D and parathyroid hormone in outpatients with noncholestatic liver disease. Clin Gastroenterol Hepatol 5: 513-520. [PMID: 17222588].
9. Miroliaee A, Nasiri-Toosi M, Khalilzadeh O, Esteghamati A, Abdollahi A, et al. (2010) Disturbances of parathyroid hormone-vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study. Hepatol Int 4: 634-640. [PMID: 21063488].
10. Petta S, Cammà C, Scazzone C, Tripodo C, Di Marco V, et al. (2010) Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C. Hepatology 51: 1158-1167. [PMID: 20162613].
11. Bitetto D, Fattovich G, Fabris C, Ceriani A, Falleti E, et al. (2011) Complementary role of vitamin D deficiency and the interleukin-28B rs12979860 C/T polymorphism in predicting antiviral response in chronic hepatitis C. Hepatology 53: 1118-1126. [PMID: 21480318].
12. Kitson MT, Dore GJ, George J, Button P, McCaughan GW, et al. (2013) Vitamin D status does not predict sustained viral response or fibrosis stage in chronic hepatitis C genotype 1 infection. J Hepatol 58: 467-472. [PMID: 23183524].
13. Bitetto D, Bortolotti N, Falleti E, Vescovo S, Fabris C, et al. (2013) Vitamin A deficiency is associated with HCV chronic infection and with unresponsiveness to interferon based antiviral therapy. Hepatology 2013; 57: 925-933. [PMID: 23213086].
14. Baur K, Mertens JC, Schmitt J, Iwata R, Stieger B, et al. (2012) The vitamin D receptor gene bAt (CCA) haplotype impairs the response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C patients. Antiviral Ther 17: 541-547. [PMID: 22300961].
15. Lange CM, Bojunga J, Ramos-Lopez E, von Wagner M, Hassler A, et al. (2011) Vitamin D deficiency and CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy. J Hepatol 54: 887-893. [PMID: 21145801].
16. Lange CM, Bibert S, Kutalik Z, Burgisser P, Cerny A, et al. (2012) A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C. PloS ONE 7: e40159. [PMID: 22808108].
17. Ladero JM, Torrejón M, Sánchez-Pobre P, Suárez A, Cuenca F, et al. (2013) Vitamin D deficiency and vitamin D therapy in chronic hepatitis C. Ann Hepatol 12: 199-204. [PMID: 23396730].
18. González-Molero I, Morcillo S, Valdés S, Pérez-Valero V, Botas P, et al. (2011) Vitamin D deficiency in Spain: a population-based cohort study. Eur J Clin Nutr 65: 321-328. [PMID: 21179052].
19. European Association for the Study of the Liver (2011). EASL Clinical Practice Guidelines: Management of hepatitis C virus infection. J Hepatol 56: 245-264. [PMID: 21371579].
20. Heid CA, Stevens J, Livak KJ, Williams PM. (1996) Real time quantitative PCR. Genome Res 6: 989-994. [PMID: 8908518].
21. Witthöft TH, Möller B, Wiedmann KH, Mauss S, Link R, et al. (2007) Safety, tolerability and efficacy of peginterferon alpha-2a and ribavirin in chronic hepatitis C in clinical practice: The German Open Safety Trial. J Viral Hepat 14: 788-796. [PMID: 17927615].
22. Chen Z, Weck KE (2002) Hepatitis C virus genotyping interrogation of the 5′untranslated region cannot accurately distinguish genotypes 1a and 1b. J Clin Microbiol 40: 3127-3134. [PMID: 12202542].
23. The French METAVIR Cooperative Study Group (1994). Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 20: 15-20. [PMID: 80200885].
24. Agúndez JA, Golka K, Martínez C, Selinski S, Blaszkewicz M, et al. (2008) Inravelin ambiguous NAT2 genotyping data. Clin Chem 54: 1390-1394. [PMID: 18864443].
25. Ladero JM, Martin EG, Fernández C, Carballo M, Devesa MJ, et al. (2012) Predicting response to therapy in chronic hepatitis C: an approach combining interleukin-28B gene polymorphisms and clinical data. J Gastroenterol Hepatol 27: 279-285. [PMID: 21722179].
26. Kitanaka S, Isojima T, Takaki M, Numakura C, Hayasaka K, et al. (2012) Association of vitamin-D related gene polymorphisms with manifestations of vitamin D deficiency in children. Endocr J 59: 1007-1014. [PMID: 22785457].
27. Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, et al. (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376: 180-188. [PMID: 20541252].