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Volumn 82, Issue 1, 2013, Pages 38-43

EGFR mutation analysis in sputum of lung cancer patients: A multitechnique study

Author keywords

Analysis of sputum; Epidermal growth factor receptor (EGFR); Genomics; Lung cancer diagnosis; Molecular diagnostics; Non small cell lung cancer; Tyrosine kinase inhibitors

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 84884417198     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2013.07.011     Document Type: Article
Times cited : (30)

References (48)
  • 2
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma S.V., Bell D.W., Settleman J., Haber D.A. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 2007, 7:169-181.
    • (2007) Nat Rev Cancer , vol.7 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 3
    • 65349165823 scopus 로고    scopus 로고
    • EGFR mutations are detected comparably in cytologic and surgical pathology specimens of nonsmall cell lung cancer
    • Smouse J.H., Cibas E.S., Jänne P.A., Joshi V.A., Zou K.H., Lindeman N.I. EGFR mutations are detected comparably in cytologic and surgical pathology specimens of nonsmall cell lung cancer. Cancer 2009, 117:67-72.
    • (2009) Cancer , vol.117 , pp. 67-72
    • Smouse, J.H.1    Cibas, E.S.2    Jänne, P.A.3    Joshi, V.A.4    Zou, K.H.5    Lindeman, N.I.6
  • 5
    • 84859429097 scopus 로고    scopus 로고
    • EGFR and KRAS mutation analysis in cytologic samples of lung adenocarcinoma enabled by laser capture microdissection
    • Chowdhuri S.R., Xi L., Pham T.H.-T., Hanson J., Rodriguez-Canales J., Berman A., et al. EGFR and KRAS mutation analysis in cytologic samples of lung adenocarcinoma enabled by laser capture microdissection. Modern Pathol 2012, 25:548-555.
    • (2012) Modern Pathol , vol.25 , pp. 548-555
    • Chowdhuri, S.R.1    Xi, L.2    Pham, T.H.-T.3    Hanson, J.4    Rodriguez-Canales, J.5    Berman, A.6
  • 6
    • 34848874552 scopus 로고    scopus 로고
    • Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines (2nd ed.)
    • Rivera M.P., Mehta A.C. Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines (2nd ed.). Chest 2007, 132:131S-148S.
    • (2007) Chest , vol.132
    • Rivera, M.P.1    Mehta, A.C.2
  • 7
    • 0028210781 scopus 로고
    • Detection of oncogene mutations in sputum precedes diagnosis of lung cancer
    • Mao L., Hruban R.H., Boyle J.O., Tockman M., Sidransky D. Detection of oncogene mutations in sputum precedes diagnosis of lung cancer. Cancer Res 1994, 54:1634-1637.
    • (1994) Cancer Res , vol.54 , pp. 1634-1637
    • Mao, L.1    Hruban, R.H.2    Boyle, J.O.3    Tockman, M.4    Sidransky, D.5
  • 8
    • 12144291697 scopus 로고    scopus 로고
    • K-ras and p16(INK4A) alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers
    • Destro A., Bianchi P., Alloisio M., Laghi L., Di Gioia S., Malesci A., et al. K-ras and p16(INK4A) alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers. Lung Cancer 2004, 44:23-32.
    • (2004) Lung Cancer , vol.44 , pp. 23-32
    • Destro, A.1    Bianchi, P.2    Alloisio, M.3    Laghi, L.4    Di Gioia, S.5    Malesci, A.6
  • 9
    • 0031720389 scopus 로고    scopus 로고
    • Detection of K-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-EXACCT
    • Somers V.A., Pietersen A.M., Theunissen P.H., Thunnissen F.B. Detection of K-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-EXACCT. J Clin Oncol 1998, 16:3061-3068.
    • (1998) J Clin Oncol , vol.16 , pp. 3061-3068
    • Somers, V.A.1    Pietersen, A.M.2    Theunissen, P.H.3    Thunnissen, F.B.4
  • 10
    • 34247217491 scopus 로고    scopus 로고
    • Predicting gene promoter methylation in non-small-cell lung cancer by evaluating sputum and serum
    • Belinsky S.A., Grimes M.J., Casas E., Stidley C.A., Franklin W.A., Bocklage T.J., et al. Predicting gene promoter methylation in non-small-cell lung cancer by evaluating sputum and serum. Br J Cancer 2007, 96:1278-1283.
    • (2007) Br J Cancer , vol.96 , pp. 1278-1283
    • Belinsky, S.A.1    Grimes, M.J.2    Casas, E.3    Stidley, C.A.4    Franklin, W.A.5    Bocklage, T.J.6
  • 12
    • 0037427083 scopus 로고    scopus 로고
    • Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients
    • Honorio S., Agathanggelou A., Schuermann M., Pankow W., Viacava P., Maher E.R., et al. Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients. Oncogene 2003, 22:147-150.
    • (2003) Oncogene , vol.22 , pp. 147-150
    • Honorio, S.1    Agathanggelou, A.2    Schuermann, M.3    Pankow, W.4    Viacava, P.5    Maher, E.R.6
  • 13
    • 79954502589 scopus 로고    scopus 로고
    • Detection of HOXA9 gene methylation in tumor tissues and induced sputum samples from primary lung cancer patients
    • Hwang S.-H., Kim K.U., Kim J.-E., Kim H.-H., Lee M.K., Lee C.H., et al. Detection of HOXA9 gene methylation in tumor tissues and induced sputum samples from primary lung cancer patients. Clin Chem Lab Med 2011, 49:699-704.
    • (2011) Clin Chem Lab Med , vol.49 , pp. 699-704
    • Hwang, S.-H.1    Kim, K.U.2    Kim, J.-E.3    Kim, H.-H.4    Lee, M.K.5    Lee, C.H.6
  • 14
    • 0034666334 scopus 로고    scopus 로고
    • Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers
    • Kersting M., Friedl C., Kraus A., Behn M., Pankow W., Schuermann M. Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers. J Clin Oncol 2000, 18:3221-3229.
    • (2000) J Clin Oncol , vol.18 , pp. 3221-3229
    • Kersting, M.1    Friedl, C.2    Kraus, A.3    Behn, M.4    Pankow, W.5    Schuermann, M.6
  • 15
    • 33845662751 scopus 로고    scopus 로고
    • Application of a methylation gene panel by quantitative PCR for lung cancers
    • Shivapurkar N., Stastny V., Suzuki M., Wistuba I.I., Li L., Zheng Y., et al. Application of a methylation gene panel by quantitative PCR for lung cancers. Cancer Lett 2007, 247:56-71.
    • (2007) Cancer Lett , vol.247 , pp. 56-71
    • Shivapurkar, N.1    Stastny, V.2    Suzuki, M.3    Wistuba, I.I.4    Li, L.5    Zheng, Y.6
  • 16
    • 77956929100 scopus 로고    scopus 로고
    • Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis
    • Tessema M., Klinge D.M., Yingling C.M., Do K., Van Neste L., Belinsky S.A. Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis. Oncogene 2010, 29:5159-5170.
    • (2010) Oncogene , vol.29 , pp. 5159-5170
    • Tessema, M.1    Klinge, D.M.2    Yingling, C.M.3    Do, K.4    Van Neste, L.5    Belinsky, S.A.6
  • 17
    • 73449096114 scopus 로고    scopus 로고
    • Frequency of and variables associated with the EGFR mutation and its subtypes
    • Tanaka T., Matsuoka M., Sutani A., Gemma A., Maemondo M., Inoue A., et al. Frequency of and variables associated with the EGFR mutation and its subtypes. Int J Cancer 2010, 126:651-655.
    • (2010) Int J Cancer , vol.126 , pp. 651-655
    • Tanaka, T.1    Matsuoka, M.2    Sutani, A.3    Gemma, A.4    Maemondo, M.5    Inoue, A.6
  • 18
    • 37349121754 scopus 로고    scopus 로고
    • Mutational analysis in cytological specimens of advanced lung adenocarcinoma: a sensitive method for molecular diagnosis
    • Boldrini L., Gisfredi S., Ursino S., Camacci T., Baldini E., Melfi F., et al. Mutational analysis in cytological specimens of advanced lung adenocarcinoma: a sensitive method for molecular diagnosis. J Thorac Oncol 2007, 2:1086-1090.
    • (2007) J Thorac Oncol , vol.2 , pp. 1086-1090
    • Boldrini, L.1    Gisfredi, S.2    Ursino, S.3    Camacci, T.4    Baldini, E.5    Melfi, F.6
  • 19
    • 34848845055 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutation detection using high-resolution melting analysis predicts outcomes in patients with advanced non-small cell lung cancer treated with gefitinib
    • Takano T., Ohe Y., Tsuta K., Fukui T., Sakamoto H., Yoshida T., et al. Epidermal growth factor receptor mutation detection using high-resolution melting analysis predicts outcomes in patients with advanced non-small cell lung cancer treated with gefitinib. Clin Cancer Res 2007, 13:5385-5390.
    • (2007) Clin Cancer Res , vol.13 , pp. 5385-5390
    • Takano, T.1    Ohe, Y.2    Tsuta, K.3    Fukui, T.4    Sakamoto, H.5    Yoshida, T.6
  • 20
    • 84861821733 scopus 로고    scopus 로고
    • Prolonged sampling of spontaneous sputum improves sensitivity of hypermethylation analysis for lung cancer
    • Hubers A.J., Heideman D.A.M., Herder G.J.M., Burgers S.A., Sterk P.J., Kunst P.W., et al. Prolonged sampling of spontaneous sputum improves sensitivity of hypermethylation analysis for lung cancer. J Clin Pathol 2012, 65:541-545.
    • (2012) J Clin Pathol , vol.65 , pp. 541-545
    • Hubers, A.J.1    Heideman, D.A.M.2    Herder, G.J.M.3    Burgers, S.A.4    Sterk, P.J.5    Kunst, P.W.6
  • 21
    • 70149091283 scopus 로고    scopus 로고
    • A panel of high resolution melting (HRM) technology-based assays with direct sequencing possibility for effective mutation screening of EGFR and K-ras genes
    • Heideman D.A.M., Thunnissen F.B., Doeleman M., Kramer D., Verheul H.M., Smit E.F., et al. A panel of high resolution melting (HRM) technology-based assays with direct sequencing possibility for effective mutation screening of EGFR and K-ras genes. Cell Oncol 2009, 31:329-333.
    • (2009) Cell Oncol , vol.31 , pp. 329-333
    • Heideman, D.A.M.1    Thunnissen, F.B.2    Doeleman, M.3    Kramer, D.4    Verheul, H.M.5    Smit, E.F.6
  • 22
    • 67650257467 scopus 로고    scopus 로고
    • A fast, sensitive and accurate high resolution melting (HRM) technology-based assay to screen for common K-ras mutations
    • Kramer D., Thunnissen F.B., Gallegos-Ruiz M.I., Smit E.F., Postmus P.E., Meijer C.J.L.M., et al. A fast, sensitive and accurate high resolution melting (HRM) technology-based assay to screen for common K-ras mutations. Cell Oncol 2009, 31:161-167.
    • (2009) Cell Oncol , vol.31 , pp. 161-167
    • Kramer, D.1    Thunnissen, F.B.2    Gallegos-Ruiz, M.I.3    Smit, E.F.4    Postmus, P.E.5    Meijer, C.J.L.M.6
  • 23
    • 20044364933 scopus 로고    scopus 로고
    • EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
    • Marchetti A., Martella C., Felicioni L., Barassi F., Salvatore S., Chella A., et al. EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol 2005, 23:857-865.
    • (2005) J Clin Oncol , vol.23 , pp. 857-865
    • Marchetti, A.1    Martella, C.2    Felicioni, L.3    Barassi, F.4    Salvatore, S.5    Chella, A.6
  • 24
    • 84857087591 scopus 로고    scopus 로고
    • Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations
    • Rekhtman N., Paik P.K., Arcila M.E., Tafe L.J., Oxnard G.R., Moreira A.L., et al. Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations. Clin Cancer Res 2012, 18:1167-1176.
    • (2012) Clin Cancer Res , vol.18 , pp. 1167-1176
    • Rekhtman, N.1    Paik, P.K.2    Arcila, M.E.3    Tafe, L.J.4    Oxnard, G.R.5    Moreira, A.L.6
  • 26
    • 69949186250 scopus 로고    scopus 로고
    • Screening for epidermal growth factor receptor mutations in lung cancer
    • Rosell R., Moran T., Queralt C., Porta R., Cardenal F., Camps C., et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009, 361:958-967.
    • (2009) N Engl J Med , vol.361 , pp. 958-967
    • Rosell, R.1    Moran, T.2    Queralt, C.3    Porta, R.4    Cardenal, F.5    Camps, C.6
  • 27
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
    • Rosell R., Carcereny E., Gervais R., Vergnenegre A., Massuti B., Felip E., et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012, 13:239-246.
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3    Vergnenegre, A.4    Massuti, B.5    Felip, E.6
  • 28
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
    • Mitsudomi T., Morita S., Yatabe Y., Negoro S., Okamoto I., Tsurutani J., et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010, 11:121-128.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3    Negoro, S.4    Okamoto, I.5    Tsurutani, J.6
  • 29
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
    • Zhou C., Wu Y.-L., Chen G., Feng J., Liu X.-Q., Wang C., et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011, 12:735-742.
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.-L.2    Chen, G.3    Feng, J.4    Liu, X.-Q.5    Wang, C.6
  • 30
    • 33745985181 scopus 로고    scopus 로고
    • A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer
    • Yatabe Y., Hida T., Horio Y., Kosaka T., Takahashi T., Mitsudomi T. A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer. J Mol Diagn 2006, 8:335-341.
    • (2006) J Mol Diagn , vol.8 , pp. 335-341
    • Yatabe, Y.1    Hida, T.2    Horio, Y.3    Kosaka, T.4    Takahashi, T.5    Mitsudomi, T.6
  • 31
    • 64149087406 scopus 로고    scopus 로고
    • Coamplification at lower denaturation temperature-PCR increases mutation-detection selectivity of TaqMan-based real-time PCR
    • Li J., Wang L., Jänne P.A., Makrigiorgos G.M. Coamplification at lower denaturation temperature-PCR increases mutation-detection selectivity of TaqMan-based real-time PCR. Clin Chem 2009, 55:748-756.
    • (2009) Clin Chem , vol.55 , pp. 748-756
    • Li, J.1    Wang, L.2    Jänne, P.A.3    Makrigiorgos, G.M.4
  • 32
    • 70350704817 scopus 로고    scopus 로고
    • Two-round coamplification at lower denaturation temperature-PCR (COLD-PCR)-based sanger sequencing identifies a novel spectrum of low-level mutations in lung adenocarcinoma
    • Li J., Milbury C.A., Li C., Makrigiorgos G.M. Two-round coamplification at lower denaturation temperature-PCR (COLD-PCR)-based sanger sequencing identifies a novel spectrum of low-level mutations in lung adenocarcinoma. Hum Mutat 2009, 30:1583-1590.
    • (2009) Hum Mutat , vol.30 , pp. 1583-1590
    • Li, J.1    Milbury, C.A.2    Li, C.3    Makrigiorgos, G.M.4
  • 33
    • 65549153120 scopus 로고    scopus 로고
    • COLD-PCR: a new platform for highly improved mutation detection in cancer and genetic testing
    • Li J., Makrigiorgos G.M. COLD-PCR: a new platform for highly improved mutation detection in cancer and genetic testing. Biochem Soc Trans 2009, 37:427-432.
    • (2009) Biochem Soc Trans , vol.37 , pp. 427-432
    • Li, J.1    Makrigiorgos, G.M.2
  • 34
    • 43249116705 scopus 로고    scopus 로고
    • Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing
    • Li J., Wang L., Mamon H., Kulke M.H., Berbeco R., Makrigiorgos G.M. Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing. Nat Med 2008, 14:579-584.
    • (2008) Nat Med , vol.14 , pp. 579-584
    • Li, J.1    Wang, L.2    Mamon, H.3    Kulke, M.H.4    Berbeco, R.5    Makrigiorgos, G.M.6
  • 35
    • 33845635125 scopus 로고    scopus 로고
    • Reliability of the peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based test for epidermal growth factor receptor mutations integrated into the clinical practice for non-small cell lung cancers
    • Tanaka T., Nagai Y., Miyazawa H., Koyama N., Matsuoka S., Sutani A., et al. Reliability of the peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based test for epidermal growth factor receptor mutations integrated into the clinical practice for non-small cell lung cancers. Cancer Sci 2007, 98:246-252.
    • (2007) Cancer Sci , vol.98 , pp. 246-252
    • Tanaka, T.1    Nagai, Y.2    Miyazawa, H.3    Koyama, N.4    Matsuoka, S.5    Sutani, A.6
  • 36
    • 84872913887 scopus 로고    scopus 로고
    • Can serum be used for analyzing the EGFR mutation status in patients with advanced non-small cell lung cancer?
    • Kim S.T., Jung H.-Y., Sung J.S., Jo U.H., Tanaka T., Hagiwara K., et al. Can serum be used for analyzing the EGFR mutation status in patients with advanced non-small cell lung cancer?. Am J Clin Oncol 2012.
    • (2012) Am J Clin Oncol
    • Kim, S.T.1    Jung, H.-Y.2    Sung, J.S.3    Jo, U.H.4    Tanaka, T.5    Hagiwara, K.6
  • 37
    • 80052240913 scopus 로고    scopus 로고
    • Serum detection of epidermal growth factor receptor gene mutations using mutant-enriched sequencing in Chinese patients with advanced non-small cell lung cancer
    • Jiang B., Liu F., Yang L., Zhang W., Yuan H., Wang J., et al. Serum detection of epidermal growth factor receptor gene mutations using mutant-enriched sequencing in Chinese patients with advanced non-small cell lung cancer. J Int Med Res 2011, 39:1392-1401.
    • (2011) J Int Med Res , vol.39 , pp. 1392-1401
    • Jiang, B.1    Liu, F.2    Yang, L.3    Zhang, W.4    Yuan, H.5    Wang, J.6
  • 38
    • 79957767374 scopus 로고    scopus 로고
    • Detection of EGFR mutations in plasma DNA from lung cancer patients by mass spectrometry genotyping is predictive of tumor EGFR status and response to EGFR inhibitors
    • Brevet M., Johnson M.L., Azzoli C.G., Ladanyi M. Detection of EGFR mutations in plasma DNA from lung cancer patients by mass spectrometry genotyping is predictive of tumor EGFR status and response to EGFR inhibitors. Lung Cancer 2011, 73:96-102.
    • (2011) Lung Cancer , vol.73 , pp. 96-102
    • Brevet, M.1    Johnson, M.L.2    Azzoli, C.G.3    Ladanyi, M.4
  • 39
    • 70349850471 scopus 로고    scopus 로고
    • Detection of epidermal growth factor receptor mutations in plasma by mutant-enriched PCR assay for prediction of the response to gefitinib in patients with non-small-cell lung cancer
    • He C., Liu M., Zhou C., Zhang J., Ouyang M., Zhong N., et al. Detection of epidermal growth factor receptor mutations in plasma by mutant-enriched PCR assay for prediction of the response to gefitinib in patients with non-small-cell lung cancer. Int J Cancer 2009, 125:2393-2399.
    • (2009) Int J Cancer , vol.125 , pp. 2393-2399
    • He, C.1    Liu, M.2    Zhou, C.3    Zhang, J.4    Ouyang, M.5    Zhong, N.6
  • 41
    • 40049099220 scopus 로고    scopus 로고
    • The T790 M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
    • Yun C.-H., Mengwasser K.E., Toms A.V., Woo M.S., Greulich H., Wong K.-K., et al. The T790 M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci USA 2008, 105:2070-2075.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2070-2075
    • Yun, C.-H.1    Mengwasser, K.E.2    Toms, A.V.3    Woo, M.S.4    Greulich, H.5    Wong, K.-K.6
  • 42
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W., Miller V.A., Politi K.A., Riely G.J., Somwar R., Zakowski M.F., et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005, 2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 43
    • 38949177364 scopus 로고    scopus 로고
    • Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790 M epidermal growth factor receptor mutation
    • Miyazawa H., Tanaka T., Nagai Y., Matsuoka M., Sutani A., Udagawa K., et al. Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790 M epidermal growth factor receptor mutation. Cancer Sci 2008, 99:595-600.
    • (2008) Cancer Sci , vol.99 , pp. 595-600
    • Miyazawa, H.1    Tanaka, T.2    Nagai, Y.3    Matsuoka, M.4    Sutani, A.5    Udagawa, K.6
  • 44
    • 0242408197 scopus 로고    scopus 로고
    • Sputum examination for early detection of lung cancer
    • Thunnissen F.B.J.M. Sputum examination for early detection of lung cancer. J Clin Pathol 2003, 56:805-810.
    • (2003) J Clin Pathol , vol.56 , pp. 805-810
    • Thunnissen, F.B.J.M.1
  • 45
    • 84856609254 scopus 로고    scopus 로고
    • Sputum cytology in suspected cases of carcinoma of lung (sputum cytology a poor man's bronchoscopy!)
    • Ammanagi A.S., Dombale V.D., Miskin A.T., Dandagi G.L., Sangolli S.S. Sputum cytology in suspected cases of carcinoma of lung (sputum cytology a poor man's bronchoscopy!). Lung India 2012, 29:19-23.
    • (2012) Lung India , vol.29 , pp. 19-23
    • Ammanagi, A.S.1    Dombale, V.D.2    Miskin, A.T.3    Dandagi, G.L.4    Sangolli, S.S.5
  • 46
    • 84857414572 scopus 로고    scopus 로고
    • Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: a meta-analysis of 13 randomized trials
    • Petrelli F., Borgonovo K., Cabiddu M., Barni S. Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: a meta-analysis of 13 randomized trials. Clin Lung Cancer 2012, 13:107-114.
    • (2012) Clin Lung Cancer , vol.13 , pp. 107-114
    • Petrelli, F.1    Borgonovo, K.2    Cabiddu, M.3    Barni, S.4
  • 47
    • 84863221857 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-tyrosine kinase inhibitor therapy is effective as first-line treatment of advanced non-small-cell lung cancer with mutated EGFR: a meta-analysis from six phase III randomized controlled trials
    • Gao G., Ren S., Li A., Xu J., Xu Q., Su C., et al. Epidermal growth factor receptor-tyrosine kinase inhibitor therapy is effective as first-line treatment of advanced non-small-cell lung cancer with mutated EGFR: a meta-analysis from six phase III randomized controlled trials. Int J Cancer 2012, 131:E822-E829.
    • (2012) Int J Cancer , vol.131
    • Gao, G.1    Ren, S.2    Li, A.3    Xu, J.4    Xu, Q.5    Su, C.6
  • 48
    • 68549125100 scopus 로고    scopus 로고
    • The 2007 GOLD Guidelines: a comprehensive care framework
    • Gold P.M. The 2007 GOLD Guidelines: a comprehensive care framework. Respir Care 2009, 54:1040-1049.
    • (2009) Respir Care , vol.54 , pp. 1040-1049
    • Gold, P.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.