The mechanism of HDL lowering in hypertriglyceridemic, insulin-resistant states

Journal of Diabetes and its Complications

Volumn 16, Issue 1, 2002, Pages 24-28

  Rashid, Shirya ^a,b   Uffelman, Kristine D ^a,b   Lewis, Gary F ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

HDL; Insulin resistance; Lipases; Triglyceride

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN A1; CHOLESTEROL; CHYLOMICRON; HIGH DENSITY LIPOPROTEIN RECEPTOR; INSULIN; LIPOPROTEIN; LIVER TRIACYLGLYCEROL LIPASE; PHOSPHOLIPASE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; VERY LOW DENSITY LIPOPROTEIN;

CONFERENCE PAPER; DIABETES MELLITUS; DIET RESTRICTION; HUMAN; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LIPID METABOLISM; LIPOLYSIS; NONHUMAN; OBESITY; PRIORITY JOURNAL; RABBIT;

ANTILIPEMIC AGENTS; CHOLESTEROL, HDL; HUMANS; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; TRIGLYCERIDES;

EID: 0036177535     PISSN: 10568727     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8727(01)00191-X     Document Type: Conference Paper

References (28)

1. The Prospective Cardiovascular Munster (PROCAM) study: prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease
2. Increased apo A-I and apo A-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia
3. Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution
4. Hepatic lipase promotes a loss of apolipoprotein A-I from triglyceride-enriched human high density lipoproteins during incubation in vitro
5. Cholesteryl ester transfer protein and hepatic lipase activity promote shedding of apo A-I from HDL and subsequent formation of discoidal HDL
6. High density lipoprotein metabolism
7. High-density lipoprotein-the clinical implications of recent studies
8. Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism. Studies in transgenic mice
9. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study
10. A novel endothelial-derived lipase that modulates HDL metabolism
11. Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance
12. HDL metabolism in hypertriglyceridemic states: an overview
13. Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A-I in healthy men
14. Analysis of particle size and lipid composition as determinants of the metabolic clearance of human high density lipoproteins in a rabbit model
15. Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor BI
16. Clearance of postprandial and lipolytically-modified human HDL in rabbits and rats
17. Postprandial lipoprotein metabolism in normal and obese subjects: comparison after the vitamin A fat-loading test
18. Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities
19. Hypertriglyceridemia and its metabolic consequences as a risk factor for atherosclerotic cardiovascular disease in non-insulin-dependent diabetes mellitus
20. Production of small HDL particles after stimulation of in vivo lipolysis in hypertriglyceridemic individuals. Studies before and after triglyceride-lowering therapy
21. The relation between serum insulin levels and 8-year changes in lipid, lipoprotein, and blood pressure levels
22. Role of basal triglyceride and high density lipoprotein in determination of postprandial lipid and lipoprotein responses
23. Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia
24. Triglyceride enrichment of HDL does not alter HDL-selective cholesteryl ester clearance in rabbits
25. Dyslipidemia in type II diabetes. Implications for therapeutic intervention
26. Insulin resistance and lipoprotein metabolism
27. Insulin-independent diabetes: a defect in the activity of lipoprotein lipase in adipose tissue
28. Lipids, glucose intolerance and vascular disease: the Framingham Study