AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model

ACS Chemical Neuroscience

Volumn 4, Issue 9, 2013, Pages 1249-1255

  McFarland, Krista ^a   Price, Diana L ^b   Davis, Christopher N ^a,d   Ma, Jian Nong ^a   Bonhaus, Douglas W ^b   Burstein, Ethan S ^a   Olsson, Roger ^a,c  

^a ACADIA PHARMACEUTICALS INC   (United States)

^b Neuropore Therapies   (United States)

^c LUND UNIVERSITY   (Sweden)

^d EMD Serono Research Institute   (United States)

Author keywords

AC 186; buccal sublingual administration; gender difference; neuroprotection; Parkinson's disease; selective estrogen receptor beta agonist

Indexed keywords

AC 131; AC 186; AC 957; ANTIPARKINSON AGENT; DEAMIDOAROTINOLOL; ESTRADIOL; ESTROGEN RECEPTOR BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUROPROTECTIVE AGENT; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MALE; MOTOR PERFORMANCE; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PERIPHERAL BLOOD MONONUCLEAR CELL; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SENSORY GATING; SUBSTANTIA NIGRA;

ANIMALS; CORPUS STRIATUM; CYCLOHEXANES; CYTOKINES; DRUG EVALUATION, PRECLINICAL; ESTRADIOL; ESTROGEN RECEPTOR BETA; EXPLORATORY BEHAVIOR; FEMALE; MALE; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; OVARIECTOMY; OXIDOPAMINE; PARKINSONIAN DISORDERS; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; ROTAROD PERFORMANCE TEST; SEX FACTORS; STARTLE REACTION; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

EID: 84884404963     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn400132u     Document Type: Article

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