메뉴 건너뛰기




Volumn 81, Issue 10, 2013, Pages 3620-3626

Heme uptake mediated by lhr1 is essential for leishmania amazonensis virulence

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC ION; FERROUS ION; HEME; LEISHMANIA FERRIC REDUCTASE 1; LEISHMANIA HEME RESPONSE 1; MEMBRANE PROTEIN; MICROBIAL ENZYME; UNCLASSIFIED DRUG;

EID: 84884395432     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00687-13     Document Type: Article
Times cited : (48)

References (39)
  • 2
    • 80053071519 scopus 로고    scopus 로고
    • Leishmaniasis chemotherapy: challenges and opportunities
    • Croft SL, Olliaro P. 2011. Leishmaniasis chemotherapy: challenges and opportunities. Clin. Microbiol. Infect. 17:1478-1483.
    • (2011) Clin. Microbiol. Infect. , vol.17 , pp. 1478-1483
    • Croft, S.L.1    Olliaro, P.2
  • 3
    • 0034776373 scopus 로고    scopus 로고
    • Molecular aspects of parasite-vector and vector-host interactions in leishmaniasis
    • Sacks D, Kamhawi S. 2001. Molecular aspects of parasite-vector and vector-host interactions in leishmaniasis. Annu. Rev. Microbiol. 55:453-483.
    • (2001) Annu. Rev. Microbiol. , vol.55 , pp. 453-483
    • Sacks, D.1    Kamhawi, S.2
  • 4
    • 84863841734 scopus 로고    scopus 로고
    • Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival
    • Ueno N, Wilson ME. 2012. Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival. Trends Parasitol. 28:335-344.
    • (2012) Trends Parasitol. , vol.28 , pp. 335-344
    • Ueno, N.1    Wilson, M.E.2
  • 5
    • 38049129044 scopus 로고    scopus 로고
    • The Leishmania-macrophage interaction: a metabolic perspective
    • Naderer T, McConville MJ. 2008. The Leishmania-macrophage interaction: a metabolic perspective. Cell Microbiol. 10:301-308.
    • (2008) Cell Microbiol. , vol.10 , pp. 301-308
    • Naderer, T.1    McConville, M.J.2
  • 6
    • 84864297704 scopus 로고    scopus 로고
    • One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans
    • Hamza I, Dailey HA. 2012. One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans. Biochim. Biophys. Acta 1823:1617-1632.
    • (2012) Biochim. Biophys. Acta , vol.1823 , pp. 1617-1632
    • Hamza, I.1    Dailey, H.A.2
  • 7
    • 78649921851 scopus 로고    scopus 로고
    • Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens
    • Anzaldi LL, Skaar EP. 2010. Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens. Infect. Immun. 78:4977-4989.
    • (2010) Infect. Immun. , vol.78 , pp. 4977-4989
    • Anzaldi, L.L.1    Skaar, E.P.2
  • 8
    • 84875057433 scopus 로고    scopus 로고
    • Make it, take it, or leave it: heme metabolism of parasites
    • doi:10.1371/journal.ppat.1003088.
    • Korený L, Oborník M, Lukeš J. 2013. Make it, take it, or leave it: heme metabolism of parasites. Plos Pathog. 9:e1003088. doi:10.1371/journal.ppat.1003088.
    • (2013) Plos Pathog. , vol.9
    • Korený, L.1    Oborník, M.2    Lukeš, J.3
  • 9
    • 74149093650 scopus 로고    scopus 로고
    • Evolution of the haem synthetic pathway in kinetoplastid flagellates: an essential pathway that is not essential after all?
    • Korený L, Lukes J, Oborník M. 2010. Evolution of the haem synthetic pathway in kinetoplastid flagellates: an essential pathway that is not essential after all? Int. J. Parasitol. 40:149-156.
    • (2010) Int. J. Parasitol. , vol.40 , pp. 149-156
    • Korený, L.1    Lukes, J.2    Oborník, M.3
  • 10
    • 80054855593 scopus 로고    scopus 로고
    • Role of heme and heme-proteins in trypanosomatid essential metabolic pathways
    • doi:10.4061/2011/873230.
    • Tripodi KE, Menendez Bravo SM, Cricco JA. 2011. Role of heme and heme-proteins in trypanosomatid essential metabolic pathways. Enzyme Res. 2011:873230. doi:10.4061/2011/873230.
    • (2011) Enzyme Res. , vol.2011 , pp. 873230
    • Tripodi, K.E.1    Menendez Bravo, S.M.2    Cricco, J.A.3
  • 11
    • 0033614040 scopus 로고    scopus 로고
    • Hemoglobin endocytosis in Leishmania is mediated through a 46-kDa protein located in the flagellar pocket
    • Sengupta S, Tripathi J, Tandon R, Raje M, Roy RP, Basu SK, Mukhopadhyay A. 1999. Hemoglobin endocytosis in Leishmania is mediated through a 46-kDa protein located in the flagellar pocket. J. Biol. Chem. 274:2758-2765.
    • (1999) J. Biol. Chem. , vol.274 , pp. 2758-2765
    • Sengupta, S.1    Tripathi, J.2    Tandon, R.3    Raje, M.4    Roy, R.P.5    Basu, S.K.6    Mukhopadhyay, A.7
  • 13
    • 84864586498 scopus 로고    scopus 로고
    • Heme uptake by Leishmania amazonensis is mediated by the transmembrane protein LHR1
    • doi: 10.1371/journal.ppat.1002795.
    • Huynh C, Yuan X, Miguel DC, Renberg RL, Protchenko O, Hamza I, Andrews NW. 2012. Heme uptake by Leishmania amazonensis is mediated by the transmembrane protein LHR1. PLoS Pathog. 8:e1002795. doi: 10.1371/journal.ppat.1002795.
    • (2012) PLoS Pathog. , vol.8
    • Huynh, C.1    Yuan, X.2    Miguel, D.C.3    Renberg, R.L.4    Protchenko, O.5    Hamza, I.6    Andrews, N.W.7
  • 14
    • 0036741718 scopus 로고    scopus 로고
    • Heme deficiency interferes with the Ras-mitogen-activated protein kinase signaling pathway and expression of a subset of neuronal genes
    • Zhu Y, Hon T, Ye W, Zhang L. 2002. Heme deficiency interferes with the Ras-mitogen-activated protein kinase signaling pathway and expression of a subset of neuronal genes. Cell Growth Differ. 13:431-439.
    • (2002) Cell Growth Differ. , vol.13 , pp. 431-439
    • Zhu, Y.1    Hon, T.2    Ye, W.3    Zhang, L.4
  • 15
    • 0000756628 scopus 로고
    • The molar light absorption of pyridine ferroprotoporphyrin (pyridine haemochromogen)
    • Paul KG, Theorell H, Akeson A. 1953. The molar light absorption of pyridine ferroprotoporphyrin (pyridine haemochromogen). Acta Chem. Scand. 7:1284-1287.
    • (1953) Acta Chem. Scand. , vol.7 , pp. 1284-1287
    • Paul, K.G.1    Theorell, H.2    Akeson, A.3
  • 16
    • 79959535754 scopus 로고    scopus 로고
    • LFR1 ferric iron reductase of Leishmania amazonensis is essential for the generation of infective parasite forms
    • Flannery AR, Huynh C, Mittra B, Mortara RA, Andrews NW. 2011. LFR1 ferric iron reductase of Leishmania amazonensis is essential for the generation of infective parasite forms. J. Biol. Chem. 286:23266-23279.
    • (2011) J. Biol. Chem. , vol.286 , pp. 23266-23279
    • Flannery, A.R.1    Huynh, C.2    Mittra, B.3    Mortara, R.A.4    Andrews, N.W.5
  • 17
    • 84874577556 scopus 로고    scopus 로고
    • Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels
    • Mittra B, Cortez M, Haydock A, Ramasamy G, Myler PJ, Andrews NW. 2013. Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels. J. Exp. Med. 210:401-416.
    • (2013) J. Exp. Med. , vol.210 , pp. 401-416
    • Mittra, B.1    Cortez, M.2    Haydock, A.3    Ramasamy, G.4    Myler, P.J.5    Andrews, N.W.6
  • 18
    • 68649096361 scopus 로고    scopus 로고
    • Differential role of the Ca(2+) sensor synaptotagmin VII in macrophages and dendritic cells
    • Becker SM, Delamarre L, Mellman I, Andrews NW. 2009. Differential role of the Ca(2+) sensor synaptotagmin VII in macrophages and dendritic cells. Immunobiology 214:495-505.
    • (2009) Immunobiology , vol.214 , pp. 495-505
    • Becker, S.M.1    Delamarre, L.2    Mellman, I.3    Andrews, N.W.4
  • 20
    • 79958761668 scopus 로고    scopus 로고
    • Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200
    • Cortez M, Huynh C, Fernandes MC, Kennedy KA, Aderem A, Andrews NW. 2011. Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200. Cell Host Microbe 9:463-471.
    • (2011) Cell Host Microbe , vol.9 , pp. 463-471
    • Cortez, M.1    Huynh, C.2    Fernandes, M.C.3    Kennedy, K.A.4    Aderem, A.5    Andrews, N.W.6
  • 21
    • 0022234330 scopus 로고
    • A limiting dilution assay for quantifying Leishmania major in tissues of infected mice
    • Titus RG, Marchand M, Boon T, Louis JA. 1985. A limiting dilution assay for quantifying Leishmania major in tissues of infected mice. Parasite Immunol. 7:545-555.
    • (1985) Parasite Immunol. , vol.7 , pp. 545-555
    • Titus, R.G.1    Marchand, M.2    Boon, T.3    Louis, J.A.4
  • 22
    • 0022201827 scopus 로고
    • Heme requirement and acquisition by extracellular and intracellular stages of Leishmania mexicana amazonensis
    • Chang CS, Chang KP. 1985. Heme requirement and acquisition by extracellular and intracellular stages of Leishmania mexicana amazonensis. Mol. Biochem. Parasitol. 16:267-276.
    • (1985) Mol. Biochem. Parasitol. , vol.16 , pp. 267-276
    • Chang, C.S.1    Chang, K.P.2
  • 23
    • 0034952056 scopus 로고    scopus 로고
    • Dose-dependent differential effect of hemin on protein synthesis and cell proliferation in Leishmania donovani promastigotes cultured in vitro
    • Pal JK, Joshi-Purandare M. 2001. Dose-dependent differential effect of hemin on protein synthesis and cell proliferation in Leishmania donovani promastigotes cultured in vitro. J. Biosci. 26:225-231.
    • (2001) J. Biosci. , vol.26 , pp. 225-231
    • Pal, J.K.1    Joshi-Purandare, M.2
  • 24
    • 35548936080 scopus 로고    scopus 로고
    • Characterization of the growth behavior of Leishmania tarentolae: a new expression system for recombinant proteins
    • Fritsche C, Sitz M, Weiland N, Breitling R, Pohl HD. 2007. Characterization of the growth behavior of Leishmania tarentolae: a new expression system for recombinant proteins. J. Basic Microbiol. 47:384-393.
    • (2007) J. Basic Microbiol. , vol.47 , pp. 384-393
    • Fritsche, C.1    Sitz, M.2    Weiland, N.3    Breitling, R.4    Pohl, H.D.5
  • 26
    • 19544385970 scopus 로고    scopus 로고
    • The 3A1-La monoclonal antibody reveals key features of Leishmania (L) amazonensis metacyclic promastigotes and inhibits procyclics attachment to the sand fly midgut
    • Pinto-da-Silva LH, Fampa P, Soares DC, Oliveira SM, Souto-Padrón T, Saraiva EM. 2005. The 3A1-La monoclonal antibody reveals key features of Leishmania (L) amazonensis metacyclic promastigotes and inhibits procyclics attachment to the sand fly midgut. Int. J. Parasitol. 35:757-764.
    • (2005) Int. J. Parasitol. , vol.35 , pp. 757-764
    • Pinto-da-Silva, L.H.1    Fampa, P.2    Soares, D.C.3    Oliveira, S.M.4    Souto-Padrón, T.5    Saraiva, E.M.6
  • 27
    • 0026761319 scopus 로고
    • Transfer of zymosan (yeast cell walls) to the parasitophorous vacuoles of macrophages infected with Leishmania amazonensis
    • Veras P, de Chastellier C, Rabinovitch M. 1992. Transfer of zymosan (yeast cell walls) to the parasitophorous vacuoles of macrophages infected with Leishmania amazonensis. J. Exp. Med. 176:639-646.
    • (1992) J. Exp. Med. , vol.176 , pp. 639-646
    • Veras, P.1    de Chastellier, C.2    Rabinovitch, M.3
  • 29
    • 84864471423 scopus 로고    scopus 로고
    • Subcellular localization of iron and heme metabolism related proteins at early stages of erythrophagocytosis
    • doi:10.1371/journal.pone.0042199.
    • Delaby C, Rondeau C, Pouzet C, Willemetz A, Pilard N, Desjardins M, Canonne-Hergaux F. 2012. Subcellular localization of iron and heme metabolism related proteins at early stages of erythrophagocytosis. PLoS One 7:e42199. doi:10.1371/journal.pone.0042199.
    • (2012) PLoS One , vol.7
    • Delaby, C.1    Rondeau, C.2    Pouzet, C.3    Willemetz, A.4    Pilard, N.5    Desjardins, M.6    Canonne-Hergaux, F.7
  • 30
    • 37849011401 scopus 로고    scopus 로고
    • Hemophagocytic macrophages harbor Salmonella enterica during persistent infection
    • doi:10.1371/journalppat.0030193.
    • Nix RN, Altschuler SE, Henson PM, Detweiler CS. 2007. Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. PLoS Pathog. 3:e193. doi:10.1371/journalppat.0030193.
    • (2007) PLoS Pathog. , vol.3
    • Nix, R.N.1    Altschuler, S.E.2    Henson, P.M.3    Detweiler, C.S.4
  • 31
    • 0029921981 scopus 로고    scopus 로고
    • Mycobacterium haemophilum: microbiology and expanding clinical and geographic spectra of disease in humans
    • Saubolle MA, Kiehn TE, White MH, Rudinsky MF, Armstrong D. 1996. Mycobacterium haemophilum: microbiology and expanding clinical and geographic spectra of disease in humans. Clin. Microbiol. Rev. 9:435-447.
    • (1996) Clin. Microbiol. Rev. , vol.9 , pp. 435-447
    • Saubolle, M.A.1    Kiehn, T.E.2    White, M.H.3    Rudinsky, M.F.4    Armstrong, D.5
  • 32
    • 33645049000 scopus 로고    scopus 로고
    • Iron acquisition systems for ferric hydroxamates, haemin and haemoglobin in Listeria monocytogenes
    • Jin B, Newton SMC, Shao Y, Jiang X, Charbit A, Klebba PE. 2006. Iron acquisition systems for ferric hydroxamates, haemin and haemoglobin in Listeria monocytogenes. Mol. Microbiol. 59:1185-1198.
    • (2006) Mol. Microbiol. , vol.59 , pp. 1185-1198
    • Jin, B.1    Newton, S.M.C.2    Shao, Y.3    Jiang, X.4    Charbit, A.5    Klebba, P.E.6
  • 33
    • 67349153807 scopus 로고    scopus 로고
    • Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts
    • Gaur U, Showalter M, Hickerson S, Dalvi R, Turco SJ, Wilson ME, Beverley SM. 2009. Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts. Exp. Parasitol. 122:182-191.
    • (2009) Exp. Parasitol. , vol.122 , pp. 182-191
    • Gaur, U.1    Showalter, M.2    Hickerson, S.3    Dalvi, R.4    Turco, S.J.5    Wilson, M.E.6    Beverley, S.M.7
  • 34
    • 84859139079 scopus 로고    scopus 로고
    • Leishmania amazonensis arginase compartmentalization in the glycosome is important for parasite infectivity
    • doi: 10.1371/journal.pone.0034022.
    • da Silva MFL, Zampieri RA, Muxel SM, Beverley SM, Floeter-Winter LM. 2012. Leishmania amazonensis arginase compartmentalization in the glycosome is important for parasite infectivity. PLoS One 7:e34022. doi: 10.1371/journal.pone.0034022.
    • (2012) PLoS One , vol.7
    • da Silva, M.F.L.1    Zampieri, R.A.2    Muxel, S.M.3    Beverley, S.M.4    Floeter-Winter, L.M.5
  • 36
    • 15744396294 scopus 로고    scopus 로고
    • Immunopathogenesis of infection with the visceralizing Leishmania species
    • Wilson ME, Jeronimo SMB, Pearson RD. 2005. Immunopathogenesis of infection with the visceralizing Leishmania species. Microb. Pathog. 38: 147-160.
    • (2005) Microb. Pathog. , vol.38 , pp. 147-160
    • Wilson, M.E.1    Jeronimo, S.M.B.2    Pearson, R.D.3
  • 37
    • 77955273873 scopus 로고    scopus 로고
    • Regulatory role of nitric oxide in the reduced survival of erythrocytes in visceral leishmaniasis
    • Chowdhury KD, Sen G, Biswas T. 2010. Regulatory role of nitric oxide in the reduced survival of erythrocytes in visceral leishmaniasis. Biochim. Biophys. Acta 1800:964-976.
    • (2010) Biochim. Biophys. Acta , vol.1800 , pp. 964-976
    • Chowdhury, K.D.1    Sen, G.2    Biswas, T.3
  • 38
    • 84864479909 scopus 로고    scopus 로고
    • Sialoglycosylation of RBC in visceral leishmaniasis leads to enhanced oxidative stress, calpain-induced fragmentation of spectrin and hemolysis
    • doi:10.1371/journal.pone.0042361.
    • Samanta S, Ghoshal A, Bhattacharya K, Saha B, Walden P, Mandal C. 2012. Sialoglycosylation of RBC in visceral leishmaniasis leads to enhanced oxidative stress, calpain-induced fragmentation of spectrin and hemolysis. PLoS One 7:e42361. doi:10.1371/journal.pone.0042361.
    • (2012) PLoS One , vol.7
    • Samanta, S.1    Ghoshal, A.2    Bhattacharya, K.3    Saha, B.4    Walden, P.5    Mandal, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.