CYP17 blockade by abiraterone: Further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer

British Journal of Cancer

Volumn 100, Issue 5, 2009, Pages 671-675

  Ang, J E ^a   Olmos, D ^a,b   De Bono, J S ^a,b  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

17 hydroxylase C17,20 lyase; Abiraterone; Androgen synthesis; Castration refractory prostate cancer; CYP450c17

Indexed keywords

ABIRATERONE; ABIRATERONE ACETATE; ANDROGEN; ANDROGEN RECEPTOR; ANDROSTENEDIONE; ANTINEOPLASTIC AGENT; BICALUTAMIDE; CORTICOSTERONE; CORTICOTROPIN; CYTOCHROME P450 17; DEXAMETHASONE; DOCETAXEL; EPLERENONE; ESTROGEN; EVEROLIMUS; GEFITINIB; GLUCOCORTICOID; HYDROCORTISONE; KETOCONAZOLE; MDV 3100; PLACEBO; PRASTERONE; PREDNISOLONE; PREDNISONE; PROSTATE SPECIFIC ANTIGEN; SPIRONOLACTONE; TESTOSTERONE; TRANSCRIPTION FACTOR ETS; UNCLASSIFIED DRUG; UNINDEXED DRUG; VN 1241;

ABSENCE OF SIDE EFFECTS; ADRENAL GLAND; ANDROSTENEDIONE BLOOD LEVEL; ANTINEOPLASTIC ACTIVITY; APPARENT MINERALOCORTICOID EXCESS SYNDROME; CANCER HORMONE THERAPY; CASTRATION; CASTRATION RESISTANT PROSTATE CANCER; CLINICAL TRIAL; DRUG DOSE ESCALATION; DRUG MECHANISM; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG TOLERABILITY; ENZYME INHIBITION; GENE FUSION; HORMONE DEPENDENCE; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; LOW DRUG DOSE; LUTEINIZING HORMONE BLOOD LEVEL; MOLECULAR BIOLOGY; OFF LABEL DRUG USE; PATIENT COMPLIANCE; PATIENT SELECTION; PRIORITY JOURNAL; PROSTATE CANCER; RECEPTOR UPREGULATION; SEXUAL DEVELOPMENT; SHORT SURVEY; STEROIDOGENESIS; TESTOSTERONE BLOOD LEVEL; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR CELL;

ANDROSTENOLS; ANTINEOPLASTIC AGENTS; CLINICAL TRIALS AS TOPIC; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; HUMANS; MALE; MODELS, BIOLOGICAL; NEOPLASMS, HORMONE-DEPENDENT; ORCHIECTOMY; PROSTATIC NEOPLASMS; STEROID 17-ALPHA-HYDROXYLASE; TREATMENT FAILURE;

EID: 61749092850     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604904     Document Type: Short Survey

References (32)

1. Attard G, Reid AH, Yap TA, Raynaud F, Dowsett M, Settatree S, Barrett M, Parker C, Martins V, Folkerd E, Clark J, Cooper CS, Kaye SB, Dearnaley D, Lee G, de Bono JS (2008) Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol 26: 4563-4571
2. Auchus RJ (2004) Overview of dehydroepiandrosterone biosynthesis. Semin Reprod Med 22: 281-288
3. Barrie SE, Potter GA, Goddard PM, Haynes BP, Dowsett M, Jarman M (1994) Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase). J Steroid Biochem Mol Biol 50: 267-273
4. Bubley GJ, Carducci M, Dahut W, Dawson N, Daliani D, Eisenberger M, Figg WD, Freidlin B, Halabi S, Hudes G, Hussain M, Kaplan R, Myers C, Oh W, Petrylak DP, Reed E, Roth B, Sartor O, Scher H, Simons J, Sinibaldi V, Small EJ, Smith MR, Trump DL, Wilding G et al (1999) Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group. J Clin Oncol 17: 3461-3467
5. Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, Vessella R, Rosenfeld MG, Sawyers CL (2004) Molecular determinants of resistance to antiandrogen therapy. Nat Med 10: 33-39
6. Danila DC, Rathkopf DE, Morris MJ, Slovin SF, Schwartz LH, Farmer K, Anand A, Haqq C, Fleisher M, Scher HI (2008) Abiraterone acetate and prednisone in patients (Pts) with progressive metastatic castration resistant prostate cancer (CRPC) after failure of docetaxel-based chemotherapy. J Clin Oncol (Meet Abstr) 26: 5019
7. de Bono JS, Attard G, Reid AH, Parker C, Dowsett M, Mollife R, Yap TA, Molina A, Lee G, Dearnaley D (2008) Anti-tumor activity of abiraterone acetate (AA), a CYP17 inhibitor of androgen synthesis, in chemotherapy naive and docetaxel pre-treated castration resistant prostate cancer (CRPC). J Clin Oncol (Meet Abstr) 26: 5005
8. De Coster R, Caers I, Coene MC, Amery W, Beerens D, Haelterman C (1986) Effects of high dose ketoconazole therapy on the main plasma testicular and adrenal steroids in previously untreated prostatic cancer patients. Clin Endocrinol (Oxf) 24: 657-664
9. Ellem SJ, Risbridger GP (2007) Treating prostate cancer: a rationale for targeting local oestrogens. Nat Rev Cancer 7: 621-627
10. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P (2007) Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 18: 581-592
11. Figg WD, Liu Y, Arlen P, Gulley J, Steinberg SM, Liewehr DJ, Cox MC, Zhai S, Cremers S, Parr A, Yang X, Chen CC, Jones E, Dahut WL (2005) A randomized, phase II trial of ketoconazole plus alendronate versus ketoconazole alone in patients with androgen independent prostate cancer and bone metastases. J Urol 173: 790-796
12. Handratta VD, Vasaitis TS, Njar VC, Gediya LK, Kataria R, Chopra P, Newman Jr D, Farquhar R, Guo Z, Qiu Y, Brodie AM (2005) Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. J Med Chem 48: 2972-2984
13. Loose DS, Kan PB, Hirst MA, Marcus RA, Feldman D (1983) Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest 71: 1495-1499
14. Luthy IA, Begin DJ, Labrie F (1988) Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem 31: 845-852
15. Miller WL, Auchus RJ, Geller DH (1997) The regulation of 17,20 lyase activity. Steroids 62: 133-142
16. Millikan R, Baez L, Banerjee T, Wade J, Edwards K, Winn R, Smith TL, Logothetis C (2001) Randomized phase 2 trial of ketoconazole and ketoconazole/doxorubicin in androgen independent prostate cancer. Urol Oncol 6: 111-115
17. O'Donnell A, Judson I, Dowsett M, Raynaud F, Dearnaley D, Mason M, Harland S, Robbins A, Halbert G, Nutley B, Jarman M (2004) Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. Br J Cancer 90: 2317- 2325
18. Olmos D, Arkenau HT, Ang JE, Ledaki I, Attard G, Carden CP, Reid AH, A'Hern R, Fong PC, Oomen NB, Molife R, Dearnaley D, Parker C, Terstappen LW, de Bono JS (2009) Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience. Ann Oncol 20: 27-33
19. Pienta KJ, Bradley D (2006) Mechanisms underlying the development of androgen-independent prostate cancer. Clin Cancer Res 12: 1665-1671
20. Potter GA, Barrie SE, Jarman M, Rowlands MG (1995) Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer. J Med Chem 38: 2463-2471
21. Raghavan D, Klein EA (2008) Prostate cancer: moving forward by reinventing the wheel...but this time it is round. J Clin Oncol 26: 4535-4536
22. Reid AH, Attard G, Molife R, Olmos D, Babu ON, Thompson E, Parker C, Dearnaley D, Lee G, De-Bono JS (2008) Selective CYP17 inhibition with abiraterone acetate (AA) results in a high response rate (RR) in castration-resistant prostate cancer (CRPC) confirming the continued importance of targeting androgen receptor signaling. Genitourinary Cancer Symposium San Francisco, CA, USA. Abstract: 50
23. Rowlands MG, Barrie SE, Chan F, Houghton J, Jarman M, McCague R, Potter GA (1995) Esters of 3-pyridylacetic acid that combine potent inhibition of 17 alpha-hydroxylase/C17,20-lyase (cytochrome P45017 alpha) with resistance to esterase hydrolysis. J Med Chem 38: 4191-4197
24. Ryan CJ, Weinberg V, Rosenberg J, Fong L, Lin A, Kim J, Small EJ (2007) Phase II study of ketoconazole plus granulocyte-macrophage colony-stimulating factor for prostate cancer: effect of extent of disease on outcome. J Urol 178: 2372-2376; discussion 2377
25. Sawyers CL, Tran C, Wongvipat J, Ouk S, Yoo D, Protter AA, Hung DT, Jung ME (2007) Characterization of a new anti-androgen MDV-3100 effective in preclinical models of hormone refractory prostate cancer. Prostate Cancer Symposium Orlando, FL, USA. Abstract: 48
26. Schayowitz A, Sabnis G, Njar VC, Brodie AM (2008) Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro. Mol Cancer Ther 7: 121-132
27. Scher HI, Beer TM, Higano CS, Danila DC, Montgomery B, Shelkey J, Hirmand M, Hung D, Sawyers C (2008) Phase I/II study of MDV3100 in patients (pts) with progressive castration-resistant prostate cancer (CRPC). J Clin Oncol (Meeting Abstracts) 26: 5006
28. Small EJ, Baron A, Bok R (1997) Simultaneous antiandrogen withdrawal and treatment with ketoconazole and hydrocortisone in patients with advanced prostate carcinoma. Cancer 80: 1755-1759
29. Small EJ, Halabi S, Dawson NA, Stadler WM, Rini BI, Picus J, Gable P, Torti FM, Kaplan E, Vogelzang NJ (2004) Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583). J Clin Oncol 22: 1025-1033
30. Stanbrough M, Bubley GJ, Ross K, Golub TR, Rubin MA, Penning TM, Febbo PG, Balk SP (2006) Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res 66: 2815-2825
31. Taplin ME (2007) Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol 4: 236-244
32. Titus MA, Schell MJ, Lih FB, Tomer KB, Mohler JL (2005) Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer. Clin Cancer Res 11: 4653-4657