메뉴 건너뛰기




Volumn 48, Issue 11, 2013, Pages 1303-1310

Effect of calcium β-hydroxy-β-methylbutyrate (CaHMB) with and without resistance training in men and women 65+yrs: A randomized, double-blind pilot trial

Author keywords

Hydroxy methylbutyrate; Exercise; Fat mass; Muscle quality; Sarcopenia

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CALCIUM; CALCIUM BETA HYDROXY BETA METHYLBUTYRATE; PLACEBO; PROTEIN; UNCLASSIFIED DRUG; URIC ACID;

EID: 84884369507     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2013.08.007     Document Type: Article
Times cited : (100)

References (38)
  • 1
    • 60349095217 scopus 로고    scopus 로고
    • Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of β-hydroxy-β-methylbutyrate (HMB), l-arginine, and l-lysine
    • Baier S., Johannsen D., Abumrad N., Rathmacher J.A., Nissen S., Flakoll P. Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of β-hydroxy-β-methylbutyrate (HMB), l-arginine, and l-lysine. J. Parenter. Enter. Nutr. 2009, 33(1):71-82.
    • (2009) J. Parenter. Enter. Nutr. , vol.33 , Issue.1 , pp. 71-82
    • Baier, S.1    Johannsen, D.2    Abumrad, N.3    Rathmacher, J.A.4    Nissen, S.5    Flakoll, P.6
  • 3
    • 34447550639 scopus 로고    scopus 로고
    • Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans
    • Bamman M.M., Petrella J.K., Kim J.S., Mayhew D.L., Cross J.M. Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans. J. Appl. Phys. 2007, 102(6):2232-2239.
    • (2007) J. Appl. Phys. , vol.102 , Issue.6 , pp. 2232-2239
    • Bamman, M.M.1    Petrella, J.K.2    Kim, J.S.3    Mayhew, D.L.4    Cross, J.M.5
  • 6
    • 80053554220 scopus 로고    scopus 로고
    • Skeletal muscle protein metabolism in the elderly: interventions to counteract the 'anabolic resistance' of ageing
    • Breen L., Phillips S.M. Skeletal muscle protein metabolism in the elderly: interventions to counteract the 'anabolic resistance' of ageing. Nutr. Metab. (Lond.) 2011, 8(68). 10.1186/1743-7075-8-68.
    • (2011) Nutr. Metab. (Lond.) , vol.8 , Issue.68
    • Breen, L.1    Phillips, S.M.2
  • 7
    • 84865296096 scopus 로고    scopus 로고
    • Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice
    • Bruckbauer A., Zemel M.B., Thorpe T., Akula M.R., Stuckey A.C., Osborne D., Wall J.S. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr. Metab. (Lond.) 2012, 9(1):77.
    • (2012) Nutr. Metab. (Lond.) , vol.9 , Issue.1 , pp. 77
    • Bruckbauer, A.1    Zemel, M.B.2    Thorpe, T.3    Akula, M.R.4    Stuckey, A.C.5    Osborne, D.6    Wall, J.S.7
  • 8
    • 0028149323 scopus 로고
    • Increased protein requirements in elderly people: new data and retrospective reassessments
    • Campbell W.W., Crim M.C., Dallal G.E., Young V.R., Evans W.J. Increased protein requirements in elderly people: new data and retrospective reassessments. Am. J. Clin. Nutr. 1994, 60(4):501-509.
    • (1994) Am. J. Clin. Nutr. , vol.60 , Issue.4 , pp. 501-509
    • Campbell, W.W.1    Crim, M.C.2    Dallal, G.E.3    Young, V.R.4    Evans, W.J.5
  • 10
    • 84869495015 scopus 로고    scopus 로고
    • Body composition and its association with cardiometabolic risk factors in the elderly: a focus on sarcopenic obesity
    • Chung J.Y., Kang H.T., Lee D.C., Lee H.R., Lee Y.J. Body composition and its association with cardiometabolic risk factors in the elderly: a focus on sarcopenic obesity. Arch. Gerontol. Geriatr. 2012, 56(1):270-278.
    • (2012) Arch. Gerontol. Geriatr. , vol.56 , Issue.1 , pp. 270-278
    • Chung, J.Y.1    Kang, H.T.2    Lee, D.C.3    Lee, H.R.4    Lee, Y.J.5
  • 11
    • 4444358114 scopus 로고    scopus 로고
    • Exercise programs for older men: mode and intensity to induce the highest possible health-related benefits
    • Delecluse C., Colman V., Roelants M., Verschueren S., Derave W., Ceux T., Stijnen V. Exercise programs for older men: mode and intensity to induce the highest possible health-related benefits. Prev. Med. 2004, 39(4):823-833.
    • (2004) Prev. Med. , vol.39 , Issue.4 , pp. 823-833
    • Delecluse, C.1    Colman, V.2    Roelants, M.3    Verschueren, S.4    Derave, W.5    Ceux, T.6    Stijnen, V.7
  • 12
    • 0141566914 scopus 로고    scopus 로고
    • Invited review: aging and sarcopenia
    • Doherty T.J. Invited review: aging and sarcopenia. J. Appl. Physiol. 2003, 95(4):1717-1727.
    • (2003) J. Appl. Physiol. , vol.95 , Issue.4 , pp. 1717-1727
    • Doherty, T.J.1
  • 13
    • 35148898785 scopus 로고    scopus 로고
    • Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli
    • Eley H.L., Russell S.T., Baxter J.H., Mukerji P., Tisdale M.J. Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am. J. Physiol. Endocrinol. Metab. 2007, 293(4):E923-E931.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293 , Issue.4
    • Eley, H.L.1    Russell, S.T.2    Baxter, J.H.3    Mukerji, P.4    Tisdale, M.J.5
  • 16
    • 16544394413 scopus 로고    scopus 로고
    • Effect of β-hydroxy-β-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
    • Flakoll P., Sharp R., Baier S., Levenhagen D., Carr C., Nissen S. Effect of β-hydroxy-β-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women. Nutrition 2004, 20(5):445-451.
    • (2004) Nutrition , vol.20 , Issue.5 , pp. 445-451
    • Flakoll, P.1    Sharp, R.2    Baier, S.3    Levenhagen, D.4    Carr, C.5    Nissen, S.6
  • 17
    • 2542418311 scopus 로고    scopus 로고
    • Effects of resistance training on older adults
    • Hunter G.R., McCarthy J.P., Bamman M.M. Effects of resistance training on older adults. Sports Med. 2004, 34(5):329-348.
    • (2004) Sports Med. , vol.34 , Issue.5 , pp. 329-348
    • Hunter, G.R.1    McCarthy, J.P.2    Bamman, M.M.3
  • 18
    • 83855164069 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of the effect of aerobic vs. resistance exercise training on visceral fat
    • Ismail I., Keating S.E., Baker M.K., Johnson N.A. A systematic review and meta-analysis of the effect of aerobic vs. resistance exercise training on visceral fat. Obes. Rev. 2012, 13(1):68-91.
    • (2012) Obes. Rev. , vol.13 , Issue.1 , pp. 68-91
    • Ismail, I.1    Keating, S.E.2    Baker, M.K.3    Johnson, N.A.4
  • 20
    • 0019490512 scopus 로고
    • The Framingham disability study: II. Physical disability among the aging
    • Jette A.M., Branch L.G. The Framingham disability study: II. Physical disability among the aging. Am. J. Public Health 1981, 71(11):1211-1216.
    • (1981) Am. J. Public Health , vol.71 , Issue.11 , pp. 1211-1216
    • Jette, A.M.1    Branch, L.G.2
  • 21
    • 31544482447 scopus 로고    scopus 로고
    • Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids
    • Katsanos C.S., Kobayashi H., Sheffield-Moore M., Aarsland A., Wolfe R.R. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am. J. Clin. Nutr. 2005, 82(5):1065-1073.
    • (2005) Am. J. Clin. Nutr. , vol.82 , Issue.5 , pp. 1065-1073
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 22
    • 33745853476 scopus 로고    scopus 로고
    • A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    • Katsanos C.S., Kobayashi H., Sheffield-Moore M., Aarsland A., Wolfe R.R. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am. J. Physiol. Endocrinol. Metab. 2006, 291(2):E381-E387.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291 , Issue.2
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 24
    • 0142062997 scopus 로고    scopus 로고
    • Sarcopenia: causes, consequences, and preventions
    • Marcell T.J. Sarcopenia: causes, consequences, and preventions. J. Gerontol. 2003, 58(10):M911-M916.
    • (2003) J. Gerontol. , vol.58 , Issue.10
    • Marcell, T.J.1
  • 25
    • 0028858013 scopus 로고
    • Relationship of age-related decreases in muscle mass and strength to skeletal status
    • (Spec No:86-7)
    • Marcus R. Relationship of age-related decreases in muscle mass and strength to skeletal status. J. Gerontol. A Biol. Sci. Med. Sci. 1995, 50. (Spec No:86-7).
    • (1995) J. Gerontol. A Biol. Sci. Med. Sci. , vol.50
    • Marcus, R.1
  • 26
    • 0030945981 scopus 로고    scopus 로고
    • Effects of maximal effort strength training with different loads on dynamic strength, cross-sectional area, load-power and load-velocity relationships
    • Moss B.M., Refsnes P.E., Abildgaard A., Nicolaysen K., Jensen J. Effects of maximal effort strength training with different loads on dynamic strength, cross-sectional area, load-power and load-velocity relationships. Eur. J. Appl. Physiol. Occup. Physiol. 1997, 75(3):193-199.
    • (1997) Eur. J. Appl. Physiol. Occup. Physiol. , vol.75 , Issue.3 , pp. 193-199
    • Moss, B.M.1    Refsnes, P.E.2    Abildgaard, A.3    Nicolaysen, K.4    Jensen, J.5
  • 27
    • 0037345998 scopus 로고    scopus 로고
    • Strength and muscle quality in a well-functioning cohort of older adults: the health, aging and body composition study
    • Newman A.B., Haggerty C.L., Goodpaster B., Harris T., Kritchevsky S., Nevitt M., Visser M. Strength and muscle quality in a well-functioning cohort of older adults: the health, aging and body composition study. J. Am. Geriatr. Soc. 2003, 51(3):323-330.
    • (2003) J. Am. Geriatr. Soc. , vol.51 , Issue.3 , pp. 323-330
    • Newman, A.B.1    Haggerty, C.L.2    Goodpaster, B.3    Harris, T.4    Kritchevsky, S.5    Nevitt, M.6    Visser, M.7
  • 28
    • 0029807071 scopus 로고    scopus 로고
    • Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training
    • Nissen S., Sharp R., Ray M., Rathmacher J.A., Rice D., Fuller J.C., Abumrad N. Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training. J. Appl. Physiol. 1996, 81(5):2095-2104.
    • (1996) J. Appl. Physiol. , vol.81 , Issue.5 , pp. 2095-2104
    • Nissen, S.1    Sharp, R.2    Ray, M.3    Rathmacher, J.A.4    Rice, D.5    Fuller, J.C.6    Abumrad, N.7
  • 29
    • 38649112892 scopus 로고    scopus 로고
    • Identification of elderly fallers by muscle strength measures
    • Pijnappels M., Reeves N.D., van Dieën J.H. Identification of elderly fallers by muscle strength measures. Eur. J. Appl. Physiol. 2008, 102(5):585-592.
    • (2008) Eur. J. Appl. Physiol. , vol.102 , Issue.5 , pp. 585-592
    • Pijnappels, M.1    Reeves, N.D.2    van Dieën, J.H.3
  • 31
    • 0026031194 scopus 로고
    • The timed "up & go": a test of basic functional mobility for frail elderly persons
    • Podsiadlo D., Richardson S. The timed "up & go": a test of basic functional mobility for frail elderly persons. J. Am. Geriatr. Soc. 1991, 39(2):142.
    • (1991) J. Am. Geriatr. Soc. , vol.39 , Issue.2 , pp. 142
    • Podsiadlo, D.1    Richardson, S.2
  • 32
    • 0023792331 scopus 로고
    • Neural adaptation to resistance training
    • Sale D.G. Neural adaptation to resistance training. Med. Sci. Sports Exerc. 1988, 20(5 Suppl.):S135-S145.
    • (1988) Med. Sci. Sports Exerc. , vol.20 , Issue.5 SUPPL.
    • Sale, D.G.1
  • 33
    • 0028839691 scopus 로고
    • Effects of exercise on body composition and functional capacity of the elderly
    • (Special Issue)
    • Schwartz R.S., Evans W.J. Effects of exercise on body composition and functional capacity of the elderly. J. Gerontol. A Biol. Sci. Med. Sci. 1995, 50:147-150. (Special Issue).
    • (1995) J. Gerontol. A Biol. Sci. Med. Sci. , vol.50 , pp. 147-150
    • Schwartz, R.S.1    Evans, W.J.2
  • 35
    • 0034942611 scopus 로고    scopus 로고
    • Body composition in 70-year-old adults responds to dietary β-hydroxy-β-methylbutyrate similarly to that of young adults
    • Vukovich M.D., Stubbs N.B., Bohlken R.M. Body composition in 70-year-old adults responds to dietary β-hydroxy-β-methylbutyrate similarly to that of young adults. J. Nutr. 2001, 131(7):2049-2052.
    • (2001) J. Nutr. , vol.131 , Issue.7 , pp. 2049-2052
    • Vukovich, M.D.1    Stubbs, N.B.2    Bohlken, R.M.3
  • 36
    • 84878433123 scopus 로고    scopus 로고
    • Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism
    • Wilkinson D.J., Hossain T., Hill D.S., Phillips B.E., Crossland H., Williams J., Atherton P.J. Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. J. Physiol. 2013, 591:2911-2923.
    • (2013) J. Physiol. , vol.591 , pp. 2911-2923
    • Wilkinson, D.J.1    Hossain, T.2    Hill, D.S.3    Phillips, B.E.4    Crossland, H.5    Williams, J.6    Atherton, P.J.7
  • 37
    • 39449139944 scopus 로고    scopus 로고
    • Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: a review
    • Wilson G.J., Wilson J.M., Manninen A.H. Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: a review. Nutr. Metab. (Lond.) 2008, 5:1.
    • (2008) Nutr. Metab. (Lond.) , vol.5 , pp. 1
    • Wilson, G.J.1    Wilson, J.M.2    Manninen, A.H.3
  • 38
    • 84859805774 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats
    • Wilson J.M., Grant S.C., Lee S.R., Masad I.S., Park Y.M., Henning P.C., Kim J.S. Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats. Int. J. Sport Nutr. 2012, 9:18.
    • (2012) Int. J. Sport Nutr. , vol.9 , pp. 18
    • Wilson, J.M.1    Grant, S.C.2    Lee, S.R.3    Masad, I.S.4    Park, Y.M.5    Henning, P.C.6    Kim, J.S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.