Generation of concentration gradients in droplet-based microfluidic system with a single nanoliter-scale injection

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

Volumn 3, Issue , 2010, Pages 1814-1816

  Cai, L F ^a   Fang, Q ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Concentration gradient; Droplet; Enzyme inhibition assay; Flow injection gradient

Indexed keywords

CONCENTRATION GRADIENTS; DROPLET-BASED MICROFLUIDICS; DRUG SCREENING; FLOW INJECTION; HIGH THROUGHPUT; HIGH-THROUGHPUT SCREENING; INHIBITOR CONCENTRATION; ORDERS OF MAGNITUDE;

ENZYME INHIBITION; SCREENING;

DROPS;

EID: 84884316211     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (4)

1. "Nanoliter Microfluidic Hybrid Method for Simultaneous Screening and Optimization Validated with Crystallization of Membrane Proteins," L. Li, D. Mustafi, Q. Fu, V. Tereshko, D. L. Chen, J. D. Tice, and R. F. Ismagilov, Proceedings of the National Academy of Sciences of the United States of America, 103, 19243 (2006).
2. "Screening of Protein Crystallization Conditions on a Microfluidic Chip Using Nanoliter-Size Droplets," B. Zheng, L. S. Roach, and R. F. Ismagilov, Journal of the American Chemical Society, 125, 11170 (2003).
3. "Bonding of Glass Microfluidic Chips at Room Temperatures," Z. J. Jia, Q. Fang, and Z. L. Fang, Analytical Chemistry, 76, 5597 (2004).
4. "A Simplified Microfabrication Technology For Production of Glass Microfluidic Chips," X. F. Yin, H. Shen, and Z. L. Fang, Chinese Journal of Analytical Chemistry, 31, 116 (2003).