Radiation therapy induces the DNA damage response in peripheral blood

Oncotarget

Volumn 4, Issue 8, 2013, Pages 1143-1148

  Bakkenist, Christopher J ^a,b   Czambel, R Kenneth ^b   Clump, David A ^a   Greenberger, Joel S ^a,b   Beumer, Jan H ^b,c   Schmitz, John C ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

ATM; DNA damage response

Indexed keywords

ATM PROTEIN; DNA; GAMMA HISTONE H2AX; HISTONE H2AX; UNCLASSIFIED DRUG;

ARTICLE; BONE METASTASIS; CANCER CELL CULTURE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS RESECTION; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; KIDNEY CARCINOMA; LOWER ESOPHAGUS SPHINCTER; PANCREAS ADENOCARCINOMA; PANCREAS RESECTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PLANNING TARGET VOLUME; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RADIATION DOSE DISTRIBUTION; RADIATION RESPONSE; RADIOLOGICAL PARAMETERS; STEREOTACTIC BODY RADIATION THERAPY;

ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL LINE, TUMOR; DNA DAMAGE; DNA, NEOPLASM; HISTONES; HT29 CELLS; HUMANS; LEUKOCYTES, MONONUCLEAR; NEOPLASMS; PHOSPHORYLATION; RADIOSURGERY; TUMOR MARKERS, BIOLOGICAL;

EID: 84884299224     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1084     Document Type: Article

References (11)

1. Rogakou EP, Pilch DR, Orr AH, Ivanova VS and Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. The Journal of Biological Chemistry. 1998; 273(10):5858-5868.
2. de Feraudy S, Revet I, Bezrookove V, Feeney L and Cleaver JE. A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(15):6870-6875.
3. White JS, Yue N, Hu J and Bakkenist CJ. The ATM kinase signaling induced by the low-energy beta-particles emitted by (33)P is essential for the suppression of chromosome aberrations and is greater than that induced by the energetic beta-particles emitted by (32)P. Mutation Research. 2011; 708(1-2):28-36.
4. Valdiglesias V, Giunta S, Fenech M, Neri M and Bonassi S. gammaH2AX as a marker of DNA double strand breaks and genomic instability in human population studies [published online ahead of print Feb 13 2013]. Mutation Research. 2013; doi: 10.1016/j.mrrev.2013.02.001.
5. Bakkenist CJ and Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 2003; 421(6922):499-506.
6. White JS, Choi S and Bakkenist CJ. Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity. Cell Cycle. 2008; 7(9):1277-1284.
7. Bartkova J, Bakkenist CJ, Rajpert-De Meyts E, Skakkebaek NE, Sehested M, Lukas J, Kastan MB and Bartek J. ATM activation in normal human tissues and testicular cancer. Cell Cycle. 2005; 4(6):838-845.
8. Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE and Abraham RT. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Research. 1998; 58(19):4375-4382.
9. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM and Abraham RT. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Research. 1999; 59(17):4375-4382.
10. Jones GG, Reaper PM, Pettitt AR and Sherrington PD. The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes. Oncogene. 2004; 23(10):1911- 1921.
11. Ji J, Kinders RJ, Zhang Y, Rubinstein L, Kummar S, Parchment RE, Tomaszewski JE and Doroshow JH. Modeling pharmacodynamic response to the poly(ADPRibose) polymerase inhibitor ABT-888 in human peripheral blood mononuclear cells. PloS One. 2011; 6(10):e26152.