DOPE facilitates quaternized lipidoids (QLDs) for in vitro DNA delivery

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 9, Issue 7, 2013, Pages 849-854

  Sun, Shuo ^a   Wang, Ming ^a   Alberti, Kyle A ^a   Choy, Alex ^a   Xu, Qiaobing ^a  

^a Tufts University   (United States)

Author keywords

Helper lipid; Non viral gene delivery; Quaternized lipidoids

Indexed keywords

CARGO DELIVERY; COMBINATORIAL LIBRARY; DNA DELIVERY; ENDOSOMAL ESCAPES; GENE TRANSFECTION; NON-VIRAL GENE DELIVERY; QUATERNIZED LIPIDOIDS; STRUCTURE ACTIVITY RELATIONSHIPS;

GENE TRANSFER; GENES; LIPOSOMES; OPTIMIZATION;

DRUG THERAPY;

1,2 DIOLEOYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; DNA; GLYCEROPHOSPHOETHANOLAMINE; LIPID; LIPOSOME; QUATERNIZED LIPIDOID; UNCLASSIFIED DRUG;

ARTICLE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; ENDOSOME; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; SYNTHESIS;

HELPER LIPID; NON-VIRAL GENE DELIVERY; QUATERNIZED LIPIDOIDS;

COMBINATORIAL CHEMISTRY TECHNIQUES; DNA; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; LIPIDS; LIPOSOMES; PHOSPHATIDYLETHANOLAMINES; TRANSFECTION;

EID: 84884289987     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2013.01.006     Document Type: Article

References (24)

1. Akinc A., Zumbuehl A., Goldberg M., Leshchiner E.S., Busini V., Hossain N., et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol 2008, 26:561-569.
2. Love K.T., Mahon K.P., Levins C.G., Whitehead K.A., Querbes W., Dorkin J.R., et al. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci USA 2010, 107:1864-1869.
3. Sun S., Wang M., Knupp S.A., Soto-Feliciano Y., Hu X., Kaplan D.L., et al. Combinatorial library of lipidoids for in vitro DNA delivery. Bioconjug Chem 2011, 23:135-140.
4. Whitehead K.A., Langer R., Anderson D.G. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 2009, 8:129-138.
5. Frank-Kamenetsky M., Grefhorst A., Anderson N.N., Racie T.S., Bramlage B., Akinc A., et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci USA 2008, 105:11915-11920.
6. Akinc A., Goldberg M., Qin J., Dorkin J.R., Gamba-Vitalo C., Maier M., et al. Development of lipidoid-siRNA formulations for systemic delivery to the liver. Mol Ther 2009, 17:872-879.
7. Wang M., Sun S., Alberti K.A., Xu Q. A combinatorial library of unsaturated lipidoids for efficient intracellular gene delivery. ACS Synth Biol 2012, 1:403-407.
8. Nguyen D.N., Mahon K.P., Chikh G., Kim P., Chung H., Vicari A.P., et al. Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery. Proc Natl Acad Sci USA 2012, 109:E797-E803.
9. Zhang X.X., McIntosh T.J., Grinstaff M.W. Functional lipids and lipoplexes for improved gene delivery. Biochimie 2012, 94:42-58.
10. Torchilin V.P. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005, 4:145-160.
11. Kim T.W., Chung H., Kwon I.C., Sung H.C., Jeong S.Y. Optimization of lipid composition in cationic emulsion as in vitro and in vivo transfection agents. Pharm Res 2001, 18:54-60.
12. Xu Y.H., Szoka F.C. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry 1996, 35:5616-5623.
13. Gao X., Huang L. A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem Biophys Res Commun 1991, 179:280-285.
14. Bailey A.L., Cullis P.R. Modulation of membrane-fusion by asymmetric transbilayer distributions of amino lipids. Biochemistry 1994, 33:12573-12580.
15. Tan Y., Whitmore M., Li S., Frederik P., Huang L. LPD nanoparticles-novel nonviral vector for efficient gene delivery. Methods Mol Med 2002, 69:73-81.
16. Green J.J., Zugates G.T., Tedford N.C., Huang Y.H., Griffith L.G., Lauffenburger D.A., et al. Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus. Adv Mater 2007, 19:2836-2842.
17. Gershon H., Ghirlando R., Guttman S.B., Minsky A. Mode of formation and structural features of DNA cationic liposome complexes used for transfection. Biochemistry 1993, 32:7143-7151.
18. Smisterova J., Wagenaar A., Stuart M.C., Polushkin E., ten Brinke G., Hulst R., et al. Molecular shape of the cationic lipid controls the structure of cationic lipid/dioleylphosphatidylethanolamine-DNA complexes and the efficiency of gene delivery. J Biol Chem 2001, 276:47615-47622.
19. Hulst R., Muizebelt I., Oosting P., van der Pol C., Wagenaar A., Šmisterová J., et al. Sunfish amphiphiles: conceptually new carriers for DNA delivery. Eur J Org Chem 2004, 2004:835-849.
20. Koltover I., Salditt T., Rädler J.O., Safinya C.R. An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery. Science 1998, 281:78-81.
21. Srilakshmi G.V., Sen J., Chaudhuri A., Ramadas Y., Rao N.M. Anchor-dependent lipofection with non-glycerol based cytofectins containing single 2-hydroxyethyl head groups. Biochim Biophys Acta 2002, 1559:87-95.
22. Balasubramaniam R.P., Bennett M.J., Aberle A.M., Malone J.G., Nantz M.H., Malone R.W. Structural and functional analysis of cationic transfection lipids: the hydrophobic domain. Gene Ther 1996, 3:163-172.
23. Chesnoy S., Huang L. Structure and function of lipid-DNA complexes for gene delivery. Annu Rev Biophys Biomol Struct 2000, 29:27-47.
24. Felgner J.H., Kumar R., Sridhar C.N., Wheeler C.J., Tsai Y.J., Border R., et al. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J Biol Chem 1994, 269:2550-2561.