Effects of porous beta-tricalcium phosphate-based ceramics used as an E. coli-derived rhBMP-2 carrier for bone regeneration

Journal of Materials Science: Materials in Medicine

Volumn 24, Issue 9, 2013, Pages 2117-2127

  Lee, Jae Hyup ^a   Ryu, Mi Young ^b   Baek, Hae Ri ^a   Lee, Kyung Mee ^a   Seo, Jun Hyuk ^b   Lee, Hyun Kyung ^a   Ryu, Hyun Seung ^b  

^a Seoul National University   (South Korea)

^b Bioalpha Inc   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE ACTIVITY; BETA TRICALCIUM PHOSPHATE; BONE REGENERATION; CALVARIAL DEFECTS; CERAMIC GRANULES; CLINICAL EFFECTIVENESS; OSTEOBLASTIC DIFFERENTIATION; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 (RHBMP-2);

BONE; COMPUTERIZED TOMOGRAPHY; DEFECTS; ESCHERICHIA COLI; GRANULATION; PHOSPHATASES; RATS;

CERAMIC MATERIALS;

ALKALINE PHOSPHATASE; CALCIUM PHOSPHATE CERAMIC; POLYURETHAN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ARTICLE; BIOCOMPATIBILITY; BONE GRAFT; BONE REGENERATION; CELL DIFFERENTIATION; CERAMICS; COMPUTED TOMOGRAPHY SCANNER; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; HISTOLOGY; HUMAN; HUMAN CELL; IMAGING SYSTEM; IMPLANTATION; MATERIALS; MESENCHYMAL STEM CELL; MICRO-COMPUTED TOMOGRAPHY; MICROSCOPE; MICROSCOPY; NONHUMAN; OSTEOBLAST; POWDER; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPE; STRUCTURE ANALYSIS; TREATMENT OUTCOME; X RAY DIFFRACTION;

RATTUS;

ALKALINE PHOSPHATASE; ANIMALS; BASE SEQUENCE; BIOCOMPATIBLE MATERIALS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CALCIUM PHOSPHATES; CERAMICS; COLLAGEN TYPE I; DNA PRIMERS; ESCHERICHIA COLI; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA; X-RAY DIFFRACTION;

EID: 84884289166     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-013-4967-5     Document Type: Article

References (22)

1. Lee JH, Jang SJ, Koo TY, Suh CW, Lee EN, Lee KM, Lee HS, Baek HR. Expression, purification and osteogenic bioactivity of recombinant human BMP-2 produced by Escherichia coli. Tissue Eng Regen Med. 2011;8:8-15.
2. Vallejo LF, Brokelmann M, Marten S, Trappe S, Cabrera-Crespo J, Hoffmann A, Gross G, Weich HA, Rinas U. Renaturation and purification of bone morphogenetic protein-2 produced as inclusion bodies in high-cell-density cultures of recombinant Escherichia coli. J Biotechnol. 2002;94:185-94.
3. Lee JH, Yu CH, Yang JJ, Baek HR, Lee KM, Koo TY, Chang BS, Lee CK. Comparative study of fusion rate induced by different dosages of Escherichia coli-derived recombinant human bone morphogenetic protein-2 using hydroxyapatite carrier. Spine J. 2012;12:239-48.
4. Kim IS, Lee EN, Cho TH, Song YM, Hwang SJ, Oh JH, Park EK, Koo TY, Seo YK. Promising efficacy of Escherichia coli recombinant human bone morphogenetic protein-2 in collagen sponge for ectopic and orthotopic bone formation and comparison with mammalian cell recombinant human bone morphogenetic protein-2. Tissue Eng Part A. 2011;17:337-48.
5. Hwang CJ, Lee JH, Baek HR, Chang BS, Lee CK. Evaluation of the efficacy of Escherichia coli-derived recombinant human bone morphogenetic protein-2 in mini-pig spinal anterior interbody fusion model. J Bone Joint Surg Br. 2013;95B:217-23.
6. Carragee EJ, Hurwitz EL, Weiner BK. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J. 2011;11:471-91.
7. Salisbury EA, Olmsted-Davis EA, Davis AR. Adverse events and bone morphogenetic protein-2. Spine J. 2011;11:802.
8. Geiger M, Li RH, Friess W. Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev. 2003;55:1613-29.
9. Sohier J, Daculsi G, Sourice S, de Groot K, Layrolle P. Porous beta tricalcium phosphate scaffolds used as a BMP-2 delivery system for bone tissue engineering. J Biomed Mater Res A. 2010;92:1105-14.
10. Yang JH, Kim HJ, Kim SE, Yun YP, Bae JH, Kim SJ, Choi KH, Song HR. The effect of bone morphogenic protein-2-coated tri-calcium phosphate/hydroxyapatite on new bone formation in a rat model of femoral distraction osteogenesis. Cytotherapy. 2011;14:315-26.
11. Laffargue P, Hildebrand HF, Rtaimate M, Frayssinet P, Amoureux JP, Marchandise X. Evaluation of human recombinant bone morphogenetic protein-2-loaded tricalcium phosphate implants in rabbits' bone defects. Bone. 1999;25:55S-8S.
12. Yuan H, De Bruijn JD, Zhang X, Van Blitterswijk CA, De Groot K. Use of an osteoinductive biomaterial as a bone morphogenetic protein carrier. J Mater Sci Mater Med. 2001;12:781-6.
13. Daculsi G, LeGeros RZ, Mitre D. Crystal dissolution of biological and ceramic apatites. Calcif Tissue Int. 1989;45:95-103.
14. Barrere F, van Blitterswijk CA, de Groot K. Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics. Int J Nanomed. 2006;1:317-32.
15. Lee JH, Hwang CJ, Song BW, Koo KH, Chang BS, Lee CK. A prospective consecutive study of instrumented posterolateral lumbar fusion using synthetic hydroxyapatite (Bongros-HA) as a bone graft extender. J Biomed Mater Res A. 2009;90:804-10.
16. Lee JH, Chang BS, Jeung UO, Park KW, Kim MS, Lee CK. The first clinical trial of beta-calcium pyrophosphate as a novel bone graft extender in instrumented posterolateral lumbar fusion. Clin Orthop Surg. 2011;3:238-44.
17. Daculsi G, LeGeros RZ, Nery E, Lynch K, Kerebel B. Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization. J Biomed Mater Res. 1989;23:883-94.
18. Yamamoto M, Takahashi Y, Tabata Y. Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Biomaterials. 2003;24:4375-84.
19. Uludag H, D'Augusta D, Golden J, Li J, Timony G, Riedel R. Implantation of recombinant human bone morphogenetic proteins with biomaterial carriers: a correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model. J Biomed Mater Res. 2000;50:227-38.
20. Liu Y, Hunziker EB, Layrolle P, De Bruijn JD, De Groot K. Bone morphogenetic protein 2 incorporated into biomimetic coatings retains its biological activity. Tissue Eng. 2004;10:101-8.
21. Liu Y, de Groot K, Hunziker EB. BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model. Bone. 2005;36:745-57.
22. Luvizuto ER, Tangl S, Zanoni G, Okamoto T, Sonoda CK, Gruber R. The effect of BMP-2 on the osteoconductive properties of beta-tricalcium phosphate in rat calvaria defects. Biomaterials. 2011;32:3855-61.