Raddeanin A induces human gastric cancer cells apoptosis and inhibits their invasion in vitro

Biochemical and Biophysical Research Communications

Volumn 439, Issue 2, 2013, Pages 196-202

  Xue, Gang ^a   Zou, Xi ^b   Zhou, Jin Yong ^b   Sun, Wei ^b   Wu, Jian ^b   Xu, Jia Li ^a   Wang, Rui Ping ^b  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Adhesion; Apoptosis; Gastric cancer cell; Invasion; Raddeanin A

Indexed keywords

ANTINEOPLASTIC AGENT; BETA ACTIN; CASPASE 3; CASPASE 8; CASPASE 9; CYSTEINE; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; RADDEANIN A; SAPONIN DERIVATIVE; SURVIVIN; UNCLASSIFIED DRUG; UVOMORULIN;

APOPTOSIS; ARTICLE; CANCER CELL; CELL ADHESION; CELL ASSAY; CELL DIFFERENTIATION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CANCER; UPREGULATION; WESTERN BLOTTING; WOUND HEALING;

ADHESION; APOPTOSIS; E-CAD; E-CADHERIN; GASTRIC CANCER; GASTRIC CANCER CELL; GC; INVASION; MATRIX METALLOPROTEINASE; MMP; OD; OPTICAL DENSITY; PARP; POLY-ADP RIBOSE POLYMERASE; RADDEANIN A; RECK; REVERSION INDUCING CYSTEINE RICH PROTEIN WITH KAZAL MOTIFS;

ANEMONE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; RNA, MESSENGER; SAPONINS; STOMACH; STOMACH NEOPLASMS;

ANEMONE RADDEANA;

EID: 84884280929     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.08.060     Document Type: Article

References (28)

1. Jemal A., Bray F., Center M.M., Ferlay J., Ward E., Forman D. Global cancer statistics. CA Cancer J. Clin. 2011, 61:69-90.
2. Zhang H., Sun L.L., Meng Y.L., Song G.Y., Hu J.J., Lu P., Ji B. Survival trends in gastric cancer patients of Northeast China. World J. Gastroenterol. 2011, 21:3257-3262.
3. Wang M.K., Ding L.S., Wu F.E. Antitumor effects of Raddeanin A on S1 80, H22 and U14 cell xenografts in mice. Chin. J. Cancer 2008, 27:910-913. (article in Chinese).
4. Cao P., Wu F.E., Ding L.S. Advances in the studies on the chemical constituents and biologic activities for anemone species. Nat. Prod. Res. Dev. 2004, 16:581-584.
5. Peng S.L., Liao X., Wang F.T., Ding L.S. Antitumor effect of the saponins from anemone davidii. Nat. Prod. Res. Dev. 2001, 13:60-62. (article in Chinese).
6. Ren F.Z., Zhang X.X., Niu G.Y., Zhang L., Shan B.E., Liu G.C. Active antitumor constituents from Anemone Raddeana Regel. Chin. Tradit. Herb. Drugs 2005, 36:1975-1978. (article in Chinese).
7. Wang M.K., Ding L.S., Wu F.E. Anti-tumor activity of crude saponin from anemone raddeana regel. Chin. Appl. Environ. Biol. 2008, 14:378-382. (article in Chinese).
8. Lin X.Q., Li D.L., Yang C.S., He X.H., Fang J. Effect of Raddeanin A on the proliferation of human hepatic cancer cells HepG2. Mod. Pharm. Clin. 2009, 24:49-51. (article in Chinese).
9. Gao Y.R., An J.X., Zhu Q.Y., et al. Inhibitory effect of Raddeanin A in human non-small cell lung cancer H460 cells. Chin. J. Appl. Environ. Biol. 2010, 16:637-641. (article in Chinese).
10. Fan T.J., Han L.H., Cong R.S., et al. Caspase family proteases and apoptosis. Acta. Biochim. Biophys. Sin. 2005, 37:719-727.
11. Ghavami S., Hashemi M., Ande S.R., Yeganeh B., Xiao W., Eshraghi M., Bus C.J., Kadkhoda K., Wiechec E., Halayko A.J., Los M. Apoptosis and cancer: mutations within caspase genes. J. Med. Genet. 2009, 46:497-510.
12. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J. Cell Mol. Med. 2003, 7:249-257.
13. Brunelle K.J., Leta A. Control of mitochondrial apoptosis by the Bcl-2 family. J. Cell Sci. 2009, 122:437-441.
14. Salakou S., Kardamakis D., Zolota V., et al. Increased Bax/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis. In Vivo 2007, 21:123-132.
15. Egeblad M., Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2002, 2:161-174.
16. Seiler R., Thalmann G.N., Fleischmann A. MMP-2 and MMP-9 in lymph-node-positive bladder cancer. J. Clin. Pathol. 2011, 64:1078-1082.
17. Quaranta M., Daniele A., Coviello M., Venneri M.T., Abbate I., Caringella M.E., Tardo S.D., Divella R., Trerotoli P., Gennaro M.D., Schittulli F., Fransvea E., Giannelli G. MMP-2, MMP-9, VEGF and CA 15.3 in breast cancer. Anticancer Res. 2007, 27:3593-3600.
18. Daniele A., Zito A.F., Giannelli G., Divella R., Asselti M., Mazzocca A., Paradiso A., Quaranta M. Expression of metalloproteinases MMP-2 and MMP-9 in sentinel lymph node and serum of patients with metastatic and non-metastatic breast cancer. Anticancer Res. 2010, 30:3521-3527.
19. Stellas D., Hamidieh A.E., Patsavoudi E. Monoclonal antibody 4C5 prevents activation of MMP-2 and MMP-9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits. BMC Cell Biol. 2010, 11:51.
20. Zucker S., Vacirca J. Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev. 2004, 23:101-117.
21. Asano T., Tada M., Cheng S., et al. Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma. J. Surg. Res. 2008, 146:32-42.
22. Van der Jagt M.F., Wobbes T., Strobbe L.J., Sweep F.C., Span P.N. Metalloproteinases and their regulators in colorectal cancer. J. Surg. Oncol. 2010, 101:259-269.
23. Damodharan U., Ganesan R., Radhakrishnan U.C. Expression of MMP-2 and MMP-9 (gelatinases A and B) in human colon cancer cells. Appl. Biochem. Biotechnol. 2011, 165:1245-1252.
24. Simizu S., Takagi S., Tamura Y., Osada H. RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. Cancer Res. 2005, 65:7455-7746.
25. Pesta M., Kulada V., Topolcan O., et al. Significance of methylation status and the expression of RECK mRNA in lung tissue of patients with NSCLC. Anticancer Res. 2009, 29:4535-4539.
26. Oh J., Takahashi R., Kondo S., et al. The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 2001, 107:789-800.
27. Clark J.C., Thomas D.M., Choong P.F., Dass C.R. RECK-a newly discovered inhibitor of metastasis with prognostic significance in multiple forms of cancer. Cancer Metastasis Rev. 2007, 26:675-683.
28. Takagi S., Simizu S., Osada H. RECK negatively regulates matrix metalloproteinase-9 transcription. CancerRes. 2009, 69:1502-1508.