Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells

Journal of Molecular Medicine

Volumn 91, Issue 9, 2013, Pages 1117-1128

  Jung, Hye Jin ^a   Kim, Yonghyo ^a   Chang, Junghwa ^a   Kang, Sang Won ^b   Kim, Jeong Hun ^c   Kwon, Ho Jeong ^a  

^a Yonsei University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Seoul National University Hospital   (South Korea)

Author keywords

Endothelial cells; Mitochondrial ROS; Terpestacin; UQCRB; VEGFR2 signaling

Indexed keywords

ANTINEOPLASTIC AGENT; REACTIVE OXYGEN METABOLITE; TERPESTACIN; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRION; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; TUMOR CELL; WESTERN BLOTTING;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; BICYCLO COMPOUNDS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; MICE, NUDE; MITOCHONDRIA; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84884279452     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-013-1049-6     Document Type: Article

References (33)

1. Folkman J (2002) Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29:15-18
2. Ferrara N (2004) Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 9:2-10
3. Carmeliet P (2005) VEGF as a key mediator of angiogenesis in cancer. Oncology 69:4-10
4. Matsumoto T, Claesson-Welsh L (2001) VEGF receptor signal transduction. Sci STKE 112:re21
5. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L (2006) VEGF receptor signaling in control of vascular function. Nat Rev Mol Cell Biol 7:359-371
6. Holmes K, Roberts OL, Thomas AM, Cross MJ (2007) Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell Signal 19:2003-2012
7. Sun J, Wang DA, Jain RK, Carie A, Paquette S, Ennis E, Blaskovich MA, Baldini L, Coppola D, Hamilton AD et al (2005) Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene 24:4701-4709
8. Cardones AR, Banez LL (2006) VEGF inhibitors in cancer therapy. Curr Pharm Des 12:387-394
9. Zhang S, Cao Z, Tian H, Shen G, Ma Y, Xie H, Liu Y, Zhao C, Deng S, Yang Y et al (2011) SKLB1002, a novel potent inhibitor of VEGF receptor 2 signaling, inhibits angiogenesis and tumor growth in vivo. Clin Cancer Res 17:4439-4450
10. Ushio-Fukai M (2007) VEGF signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal 9:731-739
11. van Wetering S, van Buul JD, Quik S, Mul FP, Anthony EC, ten Klooster JP, Collard JG, Hordijk PL (2002) Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J Cell Sci 115:1837-1846
12. Wang Y, Zang QS, Liu Z, Wu Q, Maass D, Dulan G, Shaul PW, Melito L, Frantz DE, Kilgore JA et al (2011) Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species. Am J Physiol Cell Physiol 301:C695-C704
13. Jung HJ, Shim JS, Lee J, Song YM, Park KC, Choi SH, Kim ND, Yoon JH, Mungai PT, Schumacker PT et al (2010) Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing. J Biol Chem 285:11584-11595
14. Jung HJ, Lee HB, Kim CJ, Rho JR, Shin J, Kwon HJ (2003) Anti-angiogenic activity of terpestacin, a bicyclo sesterterpene from Embellisia chlamydospora. J Antibiot (Tokyo) 56:492-496
15. Jeon KS, Na HJ, Kim YM, Kwon HJ (2005) Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume. Biochem Biophys Res Commun 330:1268-1274
16. Min JK, Park H, Choi HJ, Kim Y, Pyun BJ, Agrawal V, Song BW, Jeon J, Maeng YS, Rho SS et al (2011) The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells. J Clin Invest 121:1882-1893
17. Ali MA, Choy H, Habib AA, Saha D (2007) SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia 9:370-381
18. Cheong HJ, Lee KS, Woo IS, Won JH, Byun JH (2011) Up-regulation of the DR5 expression by proteasome inhibitor MG132 augments TRAIL-induced apoptosis in soft tissue sarcoma cell lines. Cancer Res Treat 43:124-130
19. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95:11715-11720
20. Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473:298-307
21. Miller K, Wang M, Gralow J, Dickler M, Cobleigh M, Perez EA, Shenkier T, Cella D, Davidson NE (2007) Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 357:2666-2676
22. Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8:592-603
23. Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS (2009) Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15:232-239
24. Xia C, Meng Q, Liu LZ, Rojanasakul Y, Wang XR, Jiang BH (2007) Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer Res 67:10823-10830
25. Machein MR, Plate KH (2000) VEGF in brain tumors. J Neuro-Oncol 50:109-120
26. Bao S, Wu Q, Sathornsumetee S, Hao Y, Li Z, Hjelmeland AB, Shi Q, McLendon RE, Bigner DD, Rich JN (2006) Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 66:7843-7848
27. Fischer I, Gagner JP, Law M, Newcomb EW, Zagzag D (2005) Angiogenesis in gliomas: biology and molecular pathophysiology. Brain Pathol 15:297-310
28. Jung HJ, Kim KH, Kim ND, Han G, Kwon HJ (2011) Identification of a novel small molecule targeting UQCRB of mitochondrial complex III and its anti-angiogenic activity. Bioorg Med Chem Lett 21:1052-1056
29. Kim YM, Kim KE, Koh GY, Ho YS, Lee KJ (2006) Hydrogen peroxide produced by angiopoietin-1 mediates angiogenesis. Cancer Res 66:6167-6174
30. Pouysségur J, Mechta-Grigoriou F (2006) Redox regulation of the hypoxia-inducible factor. Biol Chem 387:1337-1346
31. Zhou Q, Liu LZ, Fu B, Hu X, Shi X, Fang J, Jiang BH (2007) Reactive oxygen species regulate insulin-induced VEGF and HIF-1alpha expression through the activation of p70S6K1 in human prostate cancer cells. Carcinogenesis 28:28-37
32. Lange S, Heger J, Euler G, Wartenberg M, Piper HM, Sauer H (2009) Platelet-derived growth factor BB stimulates vasculogenesis of embryonic stem cell-derived endothelial cells by calcium-mediated generation of reactive oxygen species. Cardiovasc Res 81:159-168
33. Farrell SM, Groeger G, Bhatt L, Finnegan S, O'Brien CJ, Cotter TG (2011) bFGF mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells. Eur J Neurosci 33:632-641