Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: Design, synthesis, and protein-ligand X-ray studies

Journal of Medicinal Chemistry

Volumn 56, Issue 17, 2013, Pages 6792-6802

  Ghosh, Arun K ^a   Parham, Garth L ^a   Martyr, Cuthbert D ^a   Nyalapatla, Prasanth R ^a   Osswald, Heather L ^a   Agniswamy, Johnson ^b   Wang, Yuan Fang ^b   Amano, Masayuki ^c   Weber, Irene T ^b   Mitsuya, Hiroaki ^c,d  

^a PURDUE UNIVERSITY   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c KUMAMOTO UNIVERSITY   (Japan)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,3A,6,7,8A HEXAHYDROFURO[2,3 B]BENZOFURAN 4(5H) ONE; 2,3,3A,8A TETRAHYDRO 5H FURO[2,3 B]THIOPYRANO[4,3 D]FURAN 4(7H) ONE 6,6 DIOXIDE; 3,3A,7,8A TETRAHYDRO 2H FURO[3',2':4,5]FURO[2,3 C]PYRAN 4(5H) ONE; 4 DIAZO 2H PYRAN 3,5(4H,6H) DIONE; 4 DIAZO 2H THIOPYRAN 3,5(4H,6H) DIONE 1,1 DIOXIDE; 4 HYDROXYOCTAHYDRO 5H FURO[2,3 B]THIOPYRANO[4,3 D]FURAN 6,6 DIOXIDE; 6,6 DIMETHYL 3,3A,5,6,7,8A DECAHYDROFURO[2,3 B]BENZOFURAN 4(2H) ONE; 6,6 DIMETHYLDECAHYDROFURO[2,3 B]BENZOFURAN 4 YL(4 NITROPHENYL)CARBONATE; 6,6 DIMETHYLOCTAHYDROFURO[2,3 B]BENZOFURAN 4(2H) OL; DECAHYDRO 2H PYRANO[2,3 B]BENZOFURAN 5 YL (NITROPHENYL)CARBONATE; DECAHYDROFURO[2,3 B]BENZOFURAN 4 OL; DECAHYDROFURO[2,3 B]BENZOFURAN 4 YL CARBONATE; DECAHYDROFURO[2,3 B]BENZOFURAN 4 YL(4 NITROPHENYL)CARBONATE; HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEINASE INHIBITOR; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; OCTAHYDRO 2H FURO[3',2':4,5]FURO[2,3 C]PYRAN 4 OL; OCTAHYDRO 2H PYRANO[2,3 B]BENZOFURAN 5(3H) OL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; LIGAND BINDING; NONHUMAN; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; HIV PROTEASE; HIV PROTEASE INHIBITORS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR;

EID: 84884259096     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400768f     Document Type: Article

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