The protein ERp57 contributes to EGF receptor signaling and internalization in MDA-MB-468 breast cancer cells

Journal of Cellular Biochemistry

Volumn 114, Issue 11, 2013, Pages 2461-2470

  Gaucci, Elisa ^a   Altieri, Fabio ^a   Turano, Carlo ^a   Chichiarelli, Silvia ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Egfr Activation; Immunofluorescence; Receptor Endocytosis; Rna Interference; Signal Transduction

Indexed keywords

CELL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERP57 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERNALIZATION; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

EGFR ACTIVATION; IMMUNOFLUORESCENCE; RECEPTOR ENDOCYTOSIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; CELL MEMBRANE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; PROTEIN DISULFIDE-ISOMERASES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84884239902     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24590     Document Type: Article

References (50)

1. Aiyar N, Bennett CF, Nambi P, Valinski W, Angioli M, Minnich M, Crooke ST,. 1989. Solubilization of rat liver vasopressin receptors as a complex with a guanine-nucleotide-binding protein and phosphoinositide-specific phospholipase C. Biochem J 261: 63-70.
2. Altieri F, Maras B, Eufemi M, Ferraro A, Turano C,. 1993. Purification of a 57 kDa nuclear matrix protein associated with thiol: Protein disulfide oxidoreductase and phospholipase C activities. Biochem Biophys Res Commun 194: 992-1000.
3. Alvarez RH, Valero V, Hortobagyi GN,. 2010. Emerging targeted therapies for breast cancer. J Clin Oncol 28: 3366-3379.
4. Bild A, Turkson J, Jove R,. 2002. Cytoplasmic transport of Stat3 by receptor-mediated endocytosis. EMBO J 21: 3255-3263.
5. Brankatschk B, Wichert S, Johnson S, Schaad O, Rossner M, Gruenberg J,. 2012. Regulation of the EGF transcriptional response by endocytic sorting. Sci Signal 5 (215): ra21. [doi: 10.1126/scisignal.2002351 ]
6. Brymora A, Duggin IG, Berven LA, van Dam EM, Roufogalis BD, Robinson PJ,. 2012. Identification and characterisation of the RalA-ERp57 interaction: Evidence for GDI activity of ERp57. PLoS ONE 7 (11): e50879. doi: 10.1371/journal.pone.0050879
7. Chichiarelli S, Gaucci E, Ferraro A, Grillo C, Altieri F, Cocchiola R, Arcangeli V, Turano C, Eufemi M,. 2010. Role of ERp57 in the signaling and transcriptional activity of STAT3 in a melanoma cell line. Arch Biochem Biophys 494: 178-183.
8. Cicchillitti L, Della Corte A, Di Michele M, Donati MB, Rotilio D, Scambia G,. 2010. Characterisation of a multimeric protein complex associated with ERp57 within the nucleus in paclitaxel-sensitive and -resistant epithelial ovarian cancer cells: The involvement of specific conformational states of beta-actin. Int J Oncol 37: 445-454.
9. Coppari S, Altieri F, Ferraro A, Chichiarelli S, Eufemi M, Turano C,. 2002. Nuclear localization and DNA interaction of protein disulfide isomerase ERp57 in mammalian cells. J Cell Biochem 85: 325-333.
10. Ellerman D, Myles D, Primakoff P,. 2006. A role for sperm surface protein disulfide isomerase activity in gamete fusion: Evidence for the participation of ERp57. Dev Cell 10: 831-837.
11. Eufemi M, Coppari S, Altieri F, Grillo C, Ferraro A, Turano C,. 2004. ERp57 is present in STAT3-DNA complexes. Biochem Biophys Res Commun 323: 1306-1312.
12. Ferguson K, Berger M, Mendrola J, Cho H, Leahy D, Lemmon M,. 2003. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol Cell 11: 507-517.
13. Gáborik Z, Hunyady L,. 2004. Intracellular trafficking of hormone receptors. Trends Endocrinol Metab 15 (6): 286-293.
14. Grampp T, Sauter K, Markovic B, Benke D,. 2007. γ-aminobutyric acid type B receptors are constitutively internalized via the clathrin-dependent pathway and targeted to lysosomes for degradation. J Biol Chem 282: 24157-24165.
15. Grindel BJ, Rohe B, Safford SE, Bennett JJ, Farach-Carson MC,. 2011. Tumor necrosis factor α treatment of HepG2 cells mobilizes a cytoplasmic pool of ERp57/1,2 5D(3)-MARRS to the nucleus. J Cell Biochem 112: 2606-2615.
16. Guo GG, Patel K, Kumar V, Shah M, Fried VA, Etlinger JD, Sehgal PB,. 2002. Association of the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57) with Stat3 in cytosol and plasma membrane complexes. J Interferon Cytokine Res 22: 555-563.
17. Hammad MM, Dupré DJ,. 2010. Chaperones contribute to G protein coupled receptor oligomerization, but do not participate in assembly of the G protein with the receptor signaling complex. J Mol Signal 5: 16-29.
18. Jiang X, Sorkin A,. 2002. Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells. Mol Biol Cell 13: 1522-1535.
19. Jorissen RN, Walker F, Pouliot N, Garrett TP, Ward CW, Burgess AW,. 2003. Epidermal growth factor receptor: Mechanisms of activation and signaling. Exp Cell Res 284: 31-53.
20. Jung J, Coe H, Michalak M,. 2011. Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22. FASEB J 25: 3929-3937.
21. Kharchenko M, Aksyonov A, Melikova M, Kornilova E,. 2007. Epidermal growth factor (EGF) receptor endocytosis is accompanied by reorganization of microtubule system in HeLa cells. Cell Biol Int 31: 349-359.
22. Lee A,. 2001. The glucose-regulated proteins: Stress induction and clinical applications. Trends Biochem Sci 26: 504-510.
23. Lindquist JA, Jensen ON, Mann M, Hämmerling GJ,. 1998. ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly. EMBO J 17: 2186-2195.
24. Lo H, Xia W, Wei Y, Ali-Seyed M, Huang S, Hung M,. 2005. Novel prognostic value of nuclear EGF receptor in breast cancer. Cancer Res 65: 338-348.
25. Mah SJ, Ades AM, Mir R, Siemens IR, Williamson JR, Fluharty SJ,. 1992. Association of solubilized angiotensin II receptors with phospholipase C-alpha in murine neuroblastoma NIE-115 cells. Mol Pharmacol 42: 217-226.
26. Mathea S, Li S, Schierhorn A, Jahreis G, Schiene-Fisher C,. 2011. Suppression of EGFR autophosphorylation by FKBP12. Biochemistry 50: 10844-10850.
27. McLaughlin M, Vandenbroeck K,. 2011. The endoplasmic reticulum protein folding factory and its chaperones: New targets for drug discovery ? Br J Pharmacol 162: 328-345.
28. Ndubuisi M, Guo G, Fried V, Etlinger J, Sehgal P,. 1999. Cellular physiology of STAT3: Where's the cytoplasmic monomer ? J Biol Chem 274: 25499-25509.
29. Nemere I, Safford S, Rohe B, De Souza M, Farach-Carson M,. 2004. Identification and characterization of 1,25D3 membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein. J Steroid Biochem Mol Biol 89-90: 281-285.
30. Obeid M, Tesniere A, Ghirindelli F, Fimia G, Apetoh L, Perfettini J, Castedo M, Mignon G, Panaretakis T, Casares N, Meivier D, Larochette N, Van Endert P, Ciccosanti F, Piacentini M, Zitvogel L, Kroemer G,. 2007. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 13: 54-61.
31. Oliver JD, van der Wal FJ, Bulleid NJ, High S,. 1997. Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins. Science 275: 86-88.
32. Oliveras-Ferraros C, Vazquez-Martin A, Lopez-Bonet E, Martin-Castillo B, Del Barco S, Brunet J, Menendez JA,. 2008. Growth and molecular interactions of the anti-EGFR antibody Cetuximab and the DNA cross-linking agent cisplatin in gefitinib-resistant MDA-MB-468 cells: New prospects in the treatment of triple-negative/basal-like breast cancer. Int J Oncol 33: 1165-1176.
33. Park OK, Schaefer TS, Nathans D,. 1996. In vitro activation of Stat3 by epidermal growth factor receptor kinase. Proc Natl Acad Sci USA 93: 13704-13708.
34. Pol A, Calvo M, Enrich C,. 1998. Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment. FEBS Lett 441: 34-38.
35. Polo S, Di Fiore P,. 2006. Endocytosis conducts the cell signaling orchestra. Cell 124: 897-900.
36. Porter JR, Fritz CC, Depew KM,. 2010. Discovery and development of Hsp90 inhibitors: A promising pathway for cancer therapy. Curr Opin Chem Biol 14: 412-420.
37. Ramírez-Rangel I, Bracho-Valdés I, Vázquez- Macías A, Carretero-Ortega J, Reyes-Cruz G, Vázquez-Prado J,. 2011. Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57. Mol Cell Biol 31: 1657-1671.
38. Richard CL, Farach-Carson MC, Rohe B, Nemere I, Meckling KA,. 2010. Involvement of 1,25D3-MARRS (membrane-associated, rapid response steroid binding), a novel vitamin D receptor, in growth inhibition of breast cancer cells. Exp Cell Res 316: 695-703.
39. Sanderson MP, Dempsey PJ, Dunbar AJ,. 2006. Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors. Growth Factors 24: 121-136.
40. Schelhaas M, Malmström J, Pelkmans L, Haugstetter J, Ellgaard L, Grünewald K, Helenius A,. 2007. Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. Cell 131: 516-529.
41. Sehgal PB, Guo GG, Shah M, Kumar V, Patel K,. 2002. Cytokine signaling: STATs in plasma membrane rafts. J Biol Chem 277: 12067-12074.
42. Sigismund S, Argenzio E, Tosoni D, Cavallaio E, Polo S, Di Fiore P,. 2008. Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev Cell 15: 209-219.
43. Sousa L, Lax I, Shen H, Ferguson S, Camilli P, Schlessinger J,. 2012. Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane. Proc Natl Acad Sci USA 109: 4419-4424.
44. Tunsophon S, Nemere I,. 2010. Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid-hormone- stimulated phosphate uptake. Steroids 75: 307-313.
45. Turano C, Gaucci E, Grillo C, Chichiarelli S,. 2011. ERp57/GRP58: A protein with multiple functions. Cell Mol Biol Lett 16: 539-563.
46. Walczak CP, Tsai B,. 2011. A PDI family network acts distinctly and coordinately with ERp29 to facilitate polyomavirus infection. J Virol 85: 2386-2396.
47. Wilson KJ, Gilmore JL, Foley J, Lemmon MA, Riese DJ,. 2009. Functional selectivity of EGF family peptide growth factors: Implications for cancer. Pharmacol Ther 122: 1-8.
48. Xiao G, Chung T, Pyun H, Fine R, Johnson R,. 1999. KDEL proteins are found on the surface of NG108-15 cells. Mol Brain Res 72: 121-128.
49. Yang X, Zhang Y, Li S, Liu C, Jin Z, Wang Y, Ren F, Chang Z,. 2012. Rab21 attenuates EGF-mediated MAPK signaling through enhancing EGFR internalization and degradation. Biochem Biophys Res Commun 421: 651-657.
50. Zandi R, Larsen A, Andersen P, Stockhausen M, Poulsen H,. 2007. Mechanisms for oncogenic acivation of the epidermal growth factor receptor. Cell Signal 19: 2013-2023.