Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)

Tetrahedron Letters

Volumn 54, Issue 43, 2013, Pages 5802-5807

  Huestis, Malcolm P ^a   Liu, Wendy ^a   Volgraf, Matthew ^a   Purkey, Hans E ^a   Yu, Christine ^a   Wang, Weiru ^a   Smith, Darin ^b   Vigers, Guy ^b   Dutcher, Darrin ^c   Hunt, Kevin W ^d   Siu, Michael ^a  

^a GENENTECH INC   (United States)

^b Structural Biology   (United States)

^c Array BioPharma   (United States)

^d Array BioPharma   (United States)

Author keywords

Secretase; Alzheimer's disease; Aminooxazolines; BACE; Oxazolines

Indexed keywords

AZIDE; BETA SECRETASE 1; CARBAMIC ACID; DIETHYLAMINOSULFUR TRIFLUORIDE; EPOXIDE; ISOCYANATE; ORGANOSULFUR DERIVATIVE; OXAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; UREA;

ARTICLE; BIOCHEMICAL COMPOSITION; CYCLIZATION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HYDROBORATION; IC 50; OXIDATION; PROTEINASE INHIBITION;

EID: 84884234189     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2013.07.136     Document Type: Article

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