Complexes of dual-function hemoglobin/dehaloperoxidase with substrate 2,4,6-trichlorophenol are inhibitory and indicate binding of halophenol to compound I

Biochemistry

Volumn 52, Issue 36, 2013, Pages 6203-6210

  Wang, Chunxue ^a   Lovelace, Leslie L ^a   Sun, Shengfang ^a   Dawson, John H ^a,b   Lebioda, Lukasz ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ,4 ,6-TRICHLOROPHENOL; BINDING MODES; CATALYTIC INTERMEDIATES; DISTAL HISTIDINE; MEASURED VALUES; PHYSIOLOGICAL FUNCTIONS; SUBSTRATE BINDING; WATER MOLECULE;

AMINO ACIDS; BINDING ENERGY; HYDROGEN BONDS; HYDROGEN PEROXIDE; IRON COMPOUNDS; MOLECULES; PEROXIDES; PORPHYRINS; SUBSTRATES;

COMPLEXATION;

2,4,6 TRICHLOROPHENOL; DEHALOPEROXIDASE; HALOPHENOL; HEME; HEMOGLOBIN; HISTIDINE; HYDROGEN PEROXIDE; OXYGEN; PEROXIDASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DEHALOGENATION; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; HYDROGEN BOND; LIGAND BINDING; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOSPECIFICITY; ULTRAVIOLET SPECTROSCOPY; WILD TYPE; WORM; X RAY DIFFRACTION;

ANIMALS; BINDING SITES; CATALYSIS; CHLOROPHENOLS; CRYSTALLOGRAPHY, X-RAY; HEMOGLOBINS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; PEROXIDASES; POLYCHAETA; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 84884227847     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400627w     Document Type: Article

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