The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model

Metabolism: Clinical and Experimental

Volumn 62, Issue 4, 2013, Pages 499-508

  Le, Hau D ^a   Fallon, Erica M ^a   Kalish, Brian T ^a   De Meijer, Vincent E ^a   Meisel, Jonathan A ^a   Gura, Kathleen M ^a   Nose, Vania ^b   Pan, Amy H ^a   Bistrian, Bruce R ^c   Puder, Mark ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Dietary lipid; Mouse; Omega 3; Polyunsaturated fatty acid; Triene:tetraene ratio

Indexed keywords

ALANINE AMINOTRANSFERASE; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC INTAKE; CARBOHYDRATE DIET; CONTROLLED STUDY; DIET; DISEASE MODEL; ESSENTIAL FATTY ACID DEFICIENCY; FATTY ACID ANALYSIS; FATTY LIVER; FEMALE; LIPID COMPOSITION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ARACHIDONIC ACID; DIET; DIET, FAT-RESTRICTED; DIETARY CARBOHYDRATES; DIETARY FATS; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS, ESSENTIAL; FATTY ACIDS, NONESTERIFIED; FATTY ACIDS, UNSATURATED; FEMALE; GROWTH; LIVER; MALE; MICE; MICE, INBRED C57BL;

EID: 84884212935     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2012.10.003     Document Type: Article

References (22)

1. E. Aaes-Jorgensen, E.E. Leppik, and H.W. Hayes Essential fatty acid deficiency. II. In adult rats J Nutr 66 1958 245 259
2. H.D. Le, J.A. Meisel, and V.E. de Meijer Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis JPEN J Parenter Enteral Nutr 2011 10.1177/0148607111414580
3. A.P. Simopoulos Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain Mol Neurobiol 44 2011 203 215
4. A.P. Simopoulos Importance of the ratio of omega-6/omega-3 essential fatty acids: evolutionary aspects World Rev Nutr Diet 92 2003 1 22
5. I.P. Alwayn, P.J. Javid, and K.M. Gura Do polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREPB-1 suppression or by correcting essential fatty acid deficiency Hepatology 39 2004 1176 1177 author reply 1177-1178
6. J. Folch, M. Lees, and G.H. Sloane Stanley A simple method for the isolation and purification of total lipides from animal tissues J Biol Chem 226 1957 497 509
7. W.R. Morrison, and L.M. Smith Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol J Lipid Res 5 1964 600 608
8. S. Lukovac, E.L. Los, and F. Stellaard Effects of essential fatty acid deficiency on enterohepatic circulation of bile salts in mice Am J Physiol Gastrointest Liver Physiol 297 2009 G520 G531
9. R.A. Strijbosch, S. Lee, and D.A. Arsenault Fish oil prevents essential fatty acid deficiency and enhances growth: clinical and biochemical implications Metabolism 57 2008 698 707
10. T. Saether, T.N. Tran, and H. Rootwelt Essential fatty acid deficiency induces fatty acid desaturase expression in rat epididymis, but not in testis Reproduction 133 2007 467 477
11. M. Puder, C. Valim, and J.A. Meisel Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury Ann Surg 250 2009 395 402
12. L. Aldamiz-Echevarria, A. Vallo, and M. Aguirre Essential fatty acid deficiency profile in patients with nephrotic-range proteinuria Pediatr Nephrol 22 2007 533 540
13. I.P. Alwayn, K. Gura, and V. Nose Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease Pediatr Res 57 2005 445 452
14. J.A. Meisel, H.D. Le, and V.E. de Meijer Comparison of 5 intravenous lipid emulsions and their effects on hepatic steatosis in a murine model J Pediatr Surg 46 2011 666 673
15. H.D. Le, V.E. de Meijer, and D. Zurakowski Parenteral fish oil as monotherapy improves lipid profiles in children with parenteral nutrition-associated liver disease JPEN J Parenter Enteral Nutr 34 2010 477 484
16. H.D. Le, V.E. de Meijer, and E.M. Robinson Parenteral fish-oil-based lipid emulsion improves fatty acid profiles and lipids in parenteral nutrition-dependent children Am J Clin Nutr 94 2011 749 758
17. V.E. de Meijer, H.D. Le, and J.A. Meisel Parenteral fish oil as monotherapy prevents essential fatty acid deficiency in parenteral nutrition-dependent patients J Pediatr Gastroenterol Nutr 50 2010 212 218
18. P.R. Ling, M. Puder, and B.R. Bistrian Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats Metabolism 2012 [Epub ahead of print]
19. P.R. Ling, P. Boyce, and B.R. Bistrian Role of arachidonic acid in the regulation of the inflammatory response in TNF-alpha-treated rats JPEN J Parenter Enteral Nutr 22 1998 268 275
20. H.S. Hansen, and B. Jensen Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate Biochim Biophys Acta 834 1985 357 363
21. Y. Zheng, H. Yin, and W.E. Boeglin Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope J Biol Chem 286 2011 24046 24056
22. H.S. Hansen, B. Jensen, and P. von Wettstein-Knowles Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats Biochim Biophys Acta 878 1986 284 287