HIKE, a candidate protein binding site for PH domains, is a major regulatory region of G(β) proteins

Proteins: Structure, Function and Genetics

Volumn 35, Issue 3, 1999, Pages 360-363

  Alberti, Saverio ^a,b  

^a Consorzio Mario Negri Sud ^*  (Italy)

^b Laboratorio Angela Valenti dei Fattori Genetici e Ambientali di Rischio Trombotico   (Italy)

Author keywords

G( ) proteins; Pleckstrin homology domains; Regulatory sequences

Indexed keywords

ARTICLE; BINDING SITE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; CELL MEMBRANE; GTP-BINDING PROTEINS; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033562418     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19990515)35:3<360::AID-PROT10>3.0.CO;2-J     Document Type: Article

References (21)

1. Alberti S. A phosphoinositide-binding sequence is shared by PH domain target molecules. - a model for the binding of PH domains to proteins. Proteins 1998;31:1-9.
2. Li Y, Sternweis PM, Charnecki S et al. Sites for galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase cbeta and adenylyl cyclase. J Biol Chem 1998;273: 16265-16272.
3. Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. The 2.0 A crystal structure of a heterotrimeric G protein. Nature 1996;379:311-319.
4. Yan K, Gautam N. Structural determinants for interaction with three different effectors on the G protein beta subunit. J Biol Chem 1997;272:2056-2059.
5. Ford CE, Skiba NP, Bae H et al. Molecular basis for interactions of G protein betagamma subunits with effectors. Science 1998;280: 1271-1274.
6. Leeuw T, Wu C, Schrag JD, Whiteway M, Thomas DY, Leberer E. Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases. Nature 1998;391:191-195.
7. Liu M, Yu B, Nakanishi O, Wieland T, Simon M. The Ca2+-dependent binding of calmodulin to an N-terminal motif of the heterotrimeric G protein beta subunit. J Biol Chem 1997;272: 18801-18807.
8. S. Gaudet R, Bohm A, Sigler PB. Crystal structure at 2.4 angstroms resolution of the complex of transducin beta-gamma and its regulator, phosducin. Cell 1996;87:577-588.
9. Panchenko MP, Saxena K, Li Y et al. Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure. J Biol Chem 1998;273:28298-28304.
10. Chuang TT, Paolucci L, De Blasi A. Inhibition of G protein-coupled receptor kinase subtypes by Ca2+/calmodulin. J Biol Chem 1996;271:28691-28696.
11. Inglese J, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. Trends Biochem Sci 1995;20:151-156.
12. Touhara K, Koch WJ, Hawes BE, Lefkowitz RJ. Mutational analysis of the pleckstrin homology domain of the b-adrenergic receptor kinase. J Biol Chem 1995;270:17000-17005.
13. Pitcher JA, Touhara K, Payne ES, Lefkowitz RJ. Pleckstrin homology domain-mediated membrane association and activation of the b-adrenergic receptor kinase requires coordinate interaction with Gby subunits and lipid. J Biol Chem 1995;270:11707-11710.
14. Katada T, Kusakabe K. Oinuma M, Ui M. A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the beta gamma-subunits of GTP-binding proteins. J Biol Chem 1987;262:11897-11900.
15. Alexander KA, Wakim BT, Doyle GS, Walsh KA, Storm DR. Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein. J Biol Chem 1988;263:7544-7549.
16. Lu PJ, Chen CS. Selective recognition of phosphatidylinositol 3,4,5-trisphosphate by a synthetic peptide. J Biol Chem 1997;272: 466-472.
17. Barnes JA, Gomes AV. PEST sequences in calmodulin-binding proteins. Mol Cell Biochem 1995;149-150:17-27.
18. Apel ED, Byford MF, Au D, Walsh KA, Storm DR. Identification of the protein kinase C phosphorylation site in neuromodulin. Biochemistry 1990;29:2330-2335.
19. Lemmon MA, Ferguson KM. Ph domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 1996;85:621-624.
20. Pitcher JA, Fredericks ZL, Stone WC et al. Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. J Biol Chem 1996;271:24907-24913.
21. Deloilme JC, Prichard L, Delattre O, Storm DR. The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain. J Biol Chem 1997;272:27369-27377.