Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: A randomized trial in overweight postmenopausal women

Nutrition and Diabetes

Volumn 1, Issue 1, 2011, Pages

  Bendsen, N T ^a   Chabanova, E ^b   Thomsen, H S ^c   Larsen, T M ^a   Newman, J W ^d,e   Stender, S ^b   Dyerberg, J ^a   Haugaard, S B ^b   Astrup, A ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Mental Health Services CPH   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d AGRICULTURAL RESEARCH SERVICE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

dietary intervention; ectopic fat; randomized clinical trial; trans fatty acids

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OLEIC ACID; PALMITIC ACID; SOYBEAN OIL; TRANS FATTY ACID;

ABDOMINAL FAT; ADULT; AGED; ANTHROPOMETRIC PARAMETERS; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY COMPOSITION; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIET; DIETARY INTAKE; DUAL ENERGY X RAY ABSORPTIOMETRY; DYSLIPIDEMIA; FEMALE; HUMAN; ISOCALORIC DIET; LIPID BLOOD LEVEL; LIPID STORAGE; MAJOR CLINICAL STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; POSTMENOPAUSE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; WAIST CIRCUMFERENCE; WEIGHT GAIN;

EID: 84884211373     PISSN: None     EISSN: 20444052     Source Type: Journal    
DOI: 10.1038/nutd.2010.4     Document Type: Article

References (42)

1. Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC. Trans fatty acids and cardiovascular disease. N Engl J Med 2006; 354: 1601-1613.
2. Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr 2009; 63: S22-S33.
3. Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from prospective studies with 55 000 vascular deaths. Lancet 2007; 370: 1829-1839.
4. Alberti KGMM, Zimmet P, Shaw J. Metabolic syndromeFa new world-wide definition. A consensus statement from the international diabetes federation. Diabet Med 2006; 23: 469-480.
5. Koh-Banerjee P, Chu NF, Spiegelman D, Rosner B, Colditz G, Willett Wet al. Prospective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men. Am J Clin Nutr 2003; 78: 719-727.
6. Field AE, Willett WC, Lissner L, Colditz GA. Dietary fat and weight gain among women in the nurses/' health study[ast]. Obesity 2007; 15: 967-976.
7. Kavanagh K, Jones KL, Sawyer J, Kelley K, Carr JJ, Wagner JD et al. Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys. Obesity 2007; 15: 1675-1684.
8. Colandre ME, Diez RS, Bernal CA. Metabolic effects of trans fatty acids on an experimental dietary model. Br J Nutr 2003; 89: 631-638.
9. Dorfman SE, Laurent D, Gounarides JS, Li X, Mullarkey TL, Rocheford EC et al. Metabolic implications of dietary trans-fatty acids. Obesity 2009; 17: 1200-1207.
10. Baecke J, Burema J, Frijters J. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 1982; 36: 936-942.
11. Christie WW. Lipid Analysis : Isolation, Separation, Identification, and Structural Analysis of Lipids, 3rd edn. The Oily Press: Bridgwater, 2003.
12. Møller A, Saxholt E, Christensen AT, Hartkopp HB, Hess Ygil K. Danish Food Composition Databank, revision 6.0. Food Informatics, Institute of Food Safety and Nutrition, Danish Institute for Food and Veterinary Research: Copenhagen, Denmark. http://www.foodcomp.dk/2005.
13. Mehta SR, Thomas EL, Bell JD, Johnston DG, Taylor-Robinson SD. Non-invasive means of measuring hepatic fat content. World J Gastroenterol 2008; 14: 3476-3483.
14. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
15. Ascherio A, Katan MB, Zock PL, Stampfer MJ, Willett WC. Trans fatty acids and coronary heart disease. N Engl J Med 1999; 340: 1994-1998.
16. Westerbacka J, Corner A, Tiikkainen M, Tamminen M, Vehkavaara S, Hakkinen AM et al. Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk. Diabetologia 2004; 47: 1360-1369.
17. Stender S, Astrup A, Dyerberg J. What went in when trans went out? N Engl J Med 2009; 361: 314-316.
18. Ratnayake WMN, L0Abbe MR, Mozaffarian D. Nationwide product reformulations to reduce trans fatty acids in Canada: when trans fat goes out, what goes in? Eur J Clin Nutr 2009; 63: 808-811.
19. Dyerberg J, Eskesen DC, Andersen PW, Astrup A, Buemann B, Christensen JH et al. Effects of trans-and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study. Eur J Clin Nutr 2004; 58: 1062-1070.
20. Chardigny JM, Destaillats F, Malpuech-Brugere C, Moulin J, Bauman DE, Lock AL et al. Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans Fatty Acids Collaboration (TRANSFACT) study. Am J Clin Nutr 2008; 87: 558-566.
21. Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Rosner BA et al. Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 1997; 337: 1491-1499.
22. Mozaffarian D, Abdollahi M, Campos H, HoushiarRad A, Willett WC. Consumption of trans fats and estimated effects on coronary heart disease in Iran. Eur J Clin Nutr 2007; 61: 1004-1010.
23. Allison DB, Egan S, Barraj L, Caughman C, Infante M, Heimbach J. Estimated intakes of trans fatty and other fatty acids in the US population. J Am Diet Assoc 1999; 99: 166-174.
24. L'Abbe MR, Stender S, Skeaff CM, Ghafoorunissa, Tavella M. Approaches to removing trans fats from the food supply in industrialized and developing countries. Eur J Clin Nutr 2009; 63: S50-S67.
25. Raff M, Tholstrup T, Toubro S, Bruun JM, Lund P, Straarup EM et al. Conjugated linoleic acids reduce body fat in healthy postmenopausal women. J Nutr 2009; 139: 1347-1352.
26. Summers LKM, Fielding BA, Bradshaw HA, Ilic V, Beysen C, Clark ML et al. Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity. Diabetologia 2002; 45: 369-377.
27. Fabbrini E, Magkos F, Mohammed BS, Pietka T, Abumrad NA, Patterson BWet al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci USA 2009; 106: 15430-15435.
28. Tetri LH, Basaranoglu M, Brunt EM, Yerian LM, Neuschwander-Teri BA. Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol 2008; 295: 987-995.
29. Giudetti AM, Beynen AC, Lemmens AG, Gnoni GV, Geelen MJH. Hepatic fatty acid metabolism in rats fed diets with different contents of C18:0, C18:1cis and C18:1trans isomers. Br J Nutr 2003; 90: 887-893.
30. Koppe SWP, Elias M, Moseley RH, Green RM. Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. Am J Physiol Gastrointest Liver Physiol 2009; 297: G378-G384.
31. Bortolotti M, Kreis R, Debard C, Cariou B, Faeh D, Chetiveaux M et al. High protein intake reduces intrahepatocellular lipid deposition in humans. Am J Clin Nutr 2009; 90: 1002-1010.
32. van der Meer RW, Hammer S, Lamb HJ, Frolich M, Diamant M, Rijzewijk LJ et al. Effects of short-term high-fat, high-energy diet on hepatic and myocardial triglyceride content in healthy men. J Clin Endocrinol Metab 2008; 93/7: 2702-2708.
33. Westerbacka J, Lammi K, Hakkinen AM, Rissanen A, Salminen I, Aro A et al. Dietary fat content modifies liver fat in overweight nondiabetic subjects. J Clin Endocrinol Metab 2005; 90/5: 2804-2809.
34. Cussons AJ, Watts GF, Mori TA, Stuckey BGA. Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: a randomized controlled trial employing proton magnetic resonance spectroscopy. J Clin Endocrinol Metab 2009; 94/10: 3842-3848.
35. Spadaro L, Magliocco O, Spampinato D, Piro S, Oliveri C, Alagona C et al. Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease. Digest Liver Dis 2008; 40: 194-199.
36. Viljanen APM, Iozzo P, Borra R, Kankaanpaa M, Karmi A, Lautamaki R et al. Effect of weight loss on liver free fatty acid uptake and hepatic insulin resistance. J Clin Endocrinol Metab 2009; 94: 50-55.
37. Sato F, Tamura Y, Watada H, Kumashiro N, Igarashi Y, Uchino H et al. Effects of diet-induced moderate weight reduction on intrahepatic and intramyocellular triglycerides and glucose metabolism in obese subjects. J Clin Endocrinol Metab 2007; 92: 3326-3329.
38. Han TS, Kelly IE, Walsh K, Greene RME, Lean MEJ. Relationship between volumes and areas from single transverse scans of intra-abdominal fat measured by magnetic resonance imaging. Int J Obes 1997; 21: 1161-1166.
39. Shen W, Punyanitya M, Wang Z, Gallagher D, St-Onge MP, Albu J et al. Visceral adipose tissue: relations between single-slice areas and total volume. Am J Clin Nutr 2004; 80: 271-278.
40. Demerath EW, Shen W, Lee M, Choh AC, Czerwinski SA, Siervogel RM et al. Approximation of total visceral adipose tissue with a single magnetic resonance image. Am J Clin Nutr 2007; 85: 362-368.
41. Thomas EL, Bell JD. Influence of undersampling on magnetic resonance imaging measurements of intra-abdominal adipose tissue. Int J Obes Relat Metab Disord 2003; 27: 211-218.
42. van Werven JR, Hoogduin JM, Nederveen AJ, van Vliet AA, Wajs E, Vandenberk P et al. Reproducibility of 3.0 Tesla magnetic resonance spectroscopy for measuring hepatic fat content. J Magn Reson Imaging 2009; 30: 444-448.