Manual versus automated γ-H2AX foci analysis across five European laboratories: Can this assay be used for rapid biodosimetry in a large scale radiation accident?

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 756, Issue 1-2, 2013, Pages 170-173

  Rothkamm, Kai ^a   Barnard, Stephen ^a   Ainsbury, Elizabeth A ^a   Al hafidh, Jenna ^a   Barquinero, Joan Francesc ^b   Lindholm, Carita ^c   Moquet, Jayne ^a   Perälä, Marjo ^c   Roch Lefèvre, Sandrine ^b   Scherthan, Harry ^d   Thierens, Hubert ^e   Vral, Anne ^e   Vandersickel, Veerle ^e  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

^b INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

^c Finnish Authority for Nuclear and Radiation Safety   (Finland)

^d Bundeswehr Institute of Radiobiology   (Germany)

^e GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Biological dosimetry; Biomarker; DNA double strand break; Gamma H2AX; Ionizing radiation; Radiation induced foci

Indexed keywords

BIOLOGICAL MARKER; HISTONE H2AX; HISTONE H2AX GAMMA; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; AUTOMATION; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; DOSIMETRY; EMERGENCY HEALTH SERVICE; EUROPE; EX VIVO STUDY; GAMMA IRRADIATION; HUMAN; HUMAN CELL; LABORATORY; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RADIATION ACCIDENT; RADIATION DOSE; RADIATION EXPOSURE; RADIATION HAZARD; RADIATION RESPONSE; SCORING SYSTEM; UNCERTAINTY;

BIOLOGICAL DOSIMETRY; BIOMARKER; DNA DOUBLE-STRAND BREAK; GAMMA-H2AX; IONIZING RADIATION; RADIATION-INDUCED FOCI;

AUTOMATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; EUROPE; GAMMA RAYS; HISTONES; HUMANS; LABORATORIES; LYMPHOCYTES; MICROSCOPY, FLUORESCENCE; RADIATION MONITORING; RADIOACTIVE HAZARD RELEASE; TIME FACTORS;

EID: 84884208702     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2013.04.012     Document Type: Article

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