Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe and well-tolerated in single doses

Digestive Diseases and Sciences

Volumn 58, Issue 9, 2013, Pages 2580-2586

  Shailubhai, Kunwar ^a,c   Comiskey, Stephen ^a   Foss, John A ^a   Feng, Rong ^a   Barrow, Laura ^b   Comer, Gail M ^a   Jacob, Gary S ^b  

^a Synergy Pharmaceuticals   (United States)

^b Synergy Pharmaceuticals Inc   (United States)

^c not available   (United States)

Author keywords

Chronic functional constipation (CC); Cyclic GMP (cGMP); Cystic fibrosis transmembrane conductance regulator (CFTR); Gastrointestinal (GI); Guanylate cyclase C (GC C); Irritable bowel syndrome constipation predominant (IBS C); Uroguanylin (UG)

Indexed keywords

PLACEBO; PLECANATIDE;

ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ADULT; ARTICLE; CONTROLLED STUDY; COUGHING; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG SAFETY; DRUG TOLERABILITY; FECES ANALYSIS; FEMALE; GASTROINTESTINAL TRACT; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; NAUSEA; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOMITING;

EID: 84884208024     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-013-2684-z     Document Type: Article

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