The health benefits and challenges of exercise training in persons living with schizophrenia: A pilot study

Brain Sciences

Volumn 3, Issue 2, 2013, Pages 821-848

  Bredin, Shannon S D ^a   Warburton, Darren E R ^a   Lang, Donna J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cardio metabolic disease; Cognitive function; Exercise; Functional limitations; Schizophrenia

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AEROBIC EXERCISE; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE; BODY COMPOSITION; CARDIOMETABOLIC RISK; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; EXERCISE; EXERCISE TOLERANCE; FEMALE; FITNESS; HEART RATE; HUMAN; HYPERTENSION; MALE; OBESITY; PHYSICAL ACTIVITY; PRACTICE GUIDELINE; QUESTIONNAIRE; SCHIZOPHRENIA; TRAINING; WAIST CIRCUMFERENCE;

EID: 84884193365     PISSN: None     EISSN: 20763425     Source Type: Journal    
DOI: 10.3390/brainsci3020821     Document Type: Article

References (107)

1. Hafner, H.; an der Heiden, W. Epidemiology of schizophrenia. Can. J. Psychiatry 1997, 42, 139-151.
2. Public Health Agency of Canada. A Report on Mental Illnesses in Canada; Public Health Agency of Canada: Ottawa, Canada, 2002.
3. Goeree, R.; Farahati, F.; Burke, N.; Blackhouse, G.; O'Reilly, D.; Pyne, J.; Tarride, J.-E. The economic burden of schizophrenia in Canada. Curr. Med. Res. Opin. 2004, 21, 2017-2028.
4. Penades, R.; Catalan, R.; Puig, O.; Masana, G.; Pujol, N.; Navarro, V.; Guarch, J.; Gasto, C. Executive function needs to be targeted to improve social functioning with cogitive remediation therapy (CRT) in schizophrenia. Psychiatry Res. 2010, 1771, 41-45.
5. Aubin, G.; Stip, E.; Gelinas, I.; Rainville, C.; Chapparo, C. Daily activities, cognition and community functioning in persons with schizophrenia. Schizophr. Res. 2009, 107, 313-318.
6. Geuze, E.; Vermetten, E.; Bremner, J.D. MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatrici disorders. Mol. Psychiatry 2005, 10, 160-184.
7. Tamminga, C.A.; Stan, A.D.; Wagner, A.D. The hippocampa formation in schizophrenia. Am. J. Psychiatry 2010, 167, 1178-1193.
8. Meda, S.A.; Stevens, M.C.; Folley, B.S.; Calhoun, V.D.; Pearlson, G.D. Evidence for anomalous network connectivity during working memory encoding in schizophrenia: An ICA based analysis. PLoS One 2009, 4, e7911.
9. Schobel, S.A.; Kelly, M.A.; Corcoran, C.M.; Van Heertum, K.; Seckinger, R.; Goetz, R.; Harkavy-Friedman, J.; Malaspina, D. Anterior hippocampal and orbitofrontal cortical structural brain abnormalities in association with cognitive deficits in schizophrenia. Schizophr. Res. 2009, 114, 110-118.
10. Ingenhoven, T.; Lafay, P.; Rinne, T.; Passchier, J.; Duivenvoorden, H. Effectiveness of pharmacotherapy for severe personality disorders: Meta-analyses of randomized control trials. J. Clin. Psychiatry 2010, 71, 14-25.
11. Penn, D.L.; Keefe, R.S.; Davis, S.M.; Meyer, P.S.; Perkins, D.O.; Losardo, D.; Lieberman, J.A. The effects of antipsychotic medications on emotion perception in patients with chronic schizophrenia in the CATIE trial. Schizophr. Res. 2009, 115, 17-23.
12. De Hert, M.; Dekker, J.M.; Wood, D.; Kahl, K.G.; Holt, R.I.; Moller, H.J. Cardiovascular disease and diabetes in people with severe mental illness position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC). Eur. Psychiatry 2009, 24, 412-424.
13. Mitchell, A.J.; Vancampfort, D.; Sweers, K.; van Winkel, R.; Yu, W.; de Hert, M. Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders-a systematic review and meta-analysis. Schizophr. Bull. 2013, 39, 306-318.
14. Coodin, S. Body mass index in persons with schizophrenia. Can. J. Psychiatry 2001, 46, 549-555.
15. Parks, J.; Svendsen, D.; Singer, P.; Foti, M. Morbidity and Mortality in People with Serious Mental Illness; National Association of State Mental Health Program Directors (NASMHPD) Medical Directors Council: Alexandria, VA, USA, 2006; p. 87.
16. Regenold, W.T.; Thapar, R.K.; Marano, C.; Gavirneni, S.; Kondapavuluru, P.V. Increased prevalence of type 2 diabetes mellitus among psychiatric inpatients with bipolar I affective and schizoaffective disorders independent of psychotropic drug use. J. Affect. Disord. 2002, 70, 19-26.
17. De Hert, M.; Mauri, M.; Shaw, K.; Wetterling, T.; Doble, A.; Giudicelli, A.; Falissard, B. The METEOR study of diabetes and other metabolic disorders in patients with schizophrenia treated with antipsychotic drugs. I. Methodology. Int. J. Methods Psychiatr. Res. 2010, 19, 195-210.
18. De Hert, M.; Correll, C.U.; Bobes, J.; Cetkovich-Bakmas, M.; Cohen, D.; Asai, I.; Detraux, J.; Gautam, S.; Moller, H.J.; Ndetei, D.M.; et al. Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry 2011, 10, 52-77.
19. Bushe, C.; Holt, R. Prevalence of diabetes and impaired glucose tolerance in patients with schizophrenia. Br. J. Psychiatry Suppl. 2004, 47, S67-S71.
20. Laursen, T.M.; Munk-Olsen, T.; Vestergaard, M. Life expectancy and cardiovascular mortality in persons with schizophrenia. Curr. Opin. Psychiatry 2012, 25, 83-88.
21. Protopopova, D.; Masopust, J.; Maly, R.; Valis, M.; Bazant, J. The prevalence of cardiometabolic risk factors and the ten-year risk of fatal cardiovascular events in patients with schizophrenia and related psychotic disorders. Psychiatr. Danub. 2012, 24, 307-313.
22. Meunch, J.; Hamer, A.M. Adverse effects of antipsychotic medications. Am. Fam. Physician 2010, 81, 617-622.
23. Maayan, L.; Vakhrusheva, J. Risperidone associated weight, leptin, and anthropometric changes in children and adolescents with psychotic disorders in early treatment. Hum. Psychopharmacol. 2010, 25, 133-138.
24. Komossa, K.; Rummel-Kluge, C.; Hunger, H.; Schmid, F.; Schwarz, S.; Duggan, L.; Kissling, W.; Leucht, S. Olanzapine versus other atypical antipsychotics for schizophrenia. Cochrane Database Syst. Rev. 2009, doi:10.1002/14651858.CD006654.pub2.
25. Stahl, S.M.; Mignon, L.; Meyer, J.M. Which comes first: Atypical antipsychotic treatment or cardiometabolic risk? Acta Psychiat. Scand. 2009, 120, 500-501.
26. Paterson, D.H.; Warburton, D.E. Physical activity and functional limitations in older adults: A systematic review related to Canada's Physical Activity Guidelines. Int. J. Behav. Nutr. Phys. Act. 2010, 7, 38.
27. Warburton, D.E.; Charlesworth, S.; Ivey, A.; Nettlefold, L.; Bredin, S.S. A systematic review of the evidence for Canada's Physical Activity Guidelines for Adults. Int. J. Behav. Nutr. Phys. Act. 2010, 7, 39.
28. Vancampfort, D.; Probst, M.; Helvik Skjaerven, L.; Catalan-Matamoros, D.; Lundvik-Gyllensten, A.; Gomez-Conesa, A.; Ijntema, R.; de Hert, M. Systematic review of the benefits of physical therapy within a multidisciplinary care approach for people with schizophrenia. Phys. Ther. 2012, 92, 11-23.
29. Beebe, L.H.; Tian, L.; Morris, N.; Goodwin, A.; Allen, S.S.; Kuldau, J. Effects of exercise on mental and physical health parameters of persons with schizophrenia. Issues Ment. Health Nurs. 2005, 26, 661-676.
30. Acil, A.A.; Dogan, S.; Dogan, O. The effects of physical exercises to mental state and quality of life in patients with schizophrenia. J. Psychiat. Ment. Health Nurs. 2008, 15, 808-815.
31. Gorczynski, P.; Falkner, G. Exercise therapy for schizophrenia. Cochrane Database Syst. Rev. 2010, doi:10.1002/14651858.CD004412.pub2.
32. Fleschner, M. Physical activity and stress resistance: Sympathetic nervous system adaptations prevent stress-induced immunosuppression. Exerc. Sport Sci. Rev. 2005, 33, 120-126.
33. Chaddock, L.; Erickson, K.I.; Prakash, R.S.; Kim, J.S.; Voss, M.W.; Vanpatter, M.; Pontifex, M.B.; Raine, L.B.; Konkel, A.; Hillman, C.H.; et al. A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Res. 2010, 1358, 172-183.
34. Laske, C.; Banschbach, S.; Stransky, E.; Bosch, S.; Straten, G.; Machann, J.; Fritsche, A.; Hipp, A.; Niess, A.; Eschweiler, G.W. Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression. Int. J. Neuropsychopharmacol. 2010, 13, 595-602.
35. Warburton, D.E.R.; Jamnik, V.K.; Bredin, S.S.D.; Gledhill, N. The Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) and electronic Physical Activity Readiness Medical Examination (ePARmed-X+). Health Fit. J. Can. 2011, 4, 3-23.
36. Warburton, D.E.R.; Bredin, S.S.D.; Jamnik, V.; Gledhill, N. Validation of the PAR-Q+ and ePARmed-X+. Health Fit. J. Can. 2011, 4, 38-46.
37. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults-The Evidence Report. National Institutes of Health. Obes. Res. 1998, 6 (Suppl. 2), 51S-209S.
38. Gledhill, N.; Jamnik, V. Canadian Physical Activity, Fitness and Lifestyle Approach, 3rd ed.; Canadian Society for Exercise Physiology: Ottawa, Canada, 2003.
39. National Institutes of Health. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National Institutes of Health: Bethesda, MD, USA, 2004.
40. Cooney, M.T.; Vartiainen, E.; Laatikainen, T.; Juolevi, A.; Dudina, A.; Graham, I.M. Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women. Am. Heart J. 2010, 159, 612-619.
41. Jones, N.L. Clinical Exercise Testing, 3rd ed.; Saunders: Philadelphia, PA, USA, 1988.
42. Godin, G.; Shephard, R.J. A simple method to assess exercise behavior in the community. Can. J. Appl. Sport Sci. 1985, 10, 141-146.
43. Godin, G.; Jobin, J.; Bouillon, J. Assessment of leisure time exercise behavior by self-report: A concurrent validity study. Can. J. Public Health 1986, 77, 359-362.
44. Trinh, L.; Plotnikoff, R.C.; Rhodes, R.E.; North, S.; Courneya, K.S. Correlates of physical activity in a population-based sample of kidney cancer survivors: An application of the theory of planned behavior. Int. J. Behav. Nutr. Phys. Act. 2012, 9, 96.
45. Godin, A. The Godin-Shephard Leisure-Time Physical Activity Questionnaire. Health Fit. J. Can. 2011, 4, 18-22.
46. Tremblay, M.S.; Warburton, D.E.; Janssen, I.; Paterson, D.H.; Latimer, A.E.; Rhodes, R.E.; Kho, M.E.; Hicks, A.; Leblanc, A.G.; Zehr, L.; et al. New canadian physical activity guidelines. Appl. Physiol. Nutr. Metab. 2011, 36, 36-46.
47. Warburton, D.E.; Nicol, C.; Bredin, S.S. Prescribing exercise as preventive therapy. Can. Med. Assoc. J. 2006, 174, 961-974.
48. Warburton, D.E.; Nicol, C.; Bredin, S.S. Health benefits of physical activity: The evidence. Can. Med. Assoc. J. 2006, 174, 801-809.
49. Warburton, D.E.R.; Bredin, S.S.D.; Giacomantonio, N. Clinical Exercise Prescription for Atrial Fibrillation; International Collaboration on Clinical Exercise Prescription: Vancouver, Canada, 2012.
50. Stone, J.A. Canadian Guidelines for Cardiac Rehabilitation and Cardiovascular Disease Prevention: Translating Knowledge into Action, 3rd ed.; Canadian Association of Cardiac Rehabilitation: Winnipeg, Cannda, 2009.
51. Pescatello, L.S.; Franklin, B.A.; Fagard, R.; Farquhar, W.B.; Kelley, G.A.; Ray, C.A. American College of Sports Medicine position stand. Exercise and hypertension. Med. Sci. Sports Exerc. 2004, 36, 533-553.
52. Verweij, L.M.; Terwee, C.B.; Proper, K.I.; Hulshof, C.T.; van Mechelen, W. Measurement error of waist circumference: Gaps in knowledge. Public Health Nutr. 2013, 16, 281-288.
53. National Institutes of Health. The Practical Guide: The Identification, Evaluation, and Treatment of Overweight and Obesity in Adults; National Institutes of Health: Bethesda, MD, USA, 2000.
54. Alberti, K.G.; Zimmet, P.; Shaw, J. The metabolic syndrome-a new worldwide definition. Lancet 2005, 366, 1059-1062.
55. Alberti, K.G.; Zimmet, P.; Shaw, J. Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet. Med. 2006, 23, 469-480.
56. Bond, D.J.; Lang, D.J.; Noronha, M.M.; Kunz, M.; Torres, I.J.; Su, W.; Honer, W.G.; Lam, R.W.; Yatham, L.N. The association of elevated body mass index with reduced brain volumes in first-episode mania. Biol. Psychiatry 2011, 70, 381-387.
57. Ward, M.A.; Carlsson, C.M.; Trivedi, M.A.; Sager, M.A.; Johnson, S.C. The effect of body mass index on global brain volume in middle-aged adults: A cross sectional study. BMC Neurol. 2005, 5, 23.
58. Taki, Y.; Kinomura, S.; Sato, K.; Inoue, K.; Goto, R.; Okada, K.; Uchida, S.; Kawashima, R.; Fukuda, H. Relationship between body mass index and gray matter volume in 1428 healthy individuals. Obesity (Silver Spring) 2008, 16, 119-124.
59. Gunstad, J.; Paul, R.H.; Cohen, R.A.; Tate, D.F.; Spitznagel, M.B.; Grieve, S.; Gordon, E. Relationship between body mass index and brain volume in healthy adults. Int. J. Neurosci. 2008, 118, 1582-1593.
60. Soreca, I.; Rosano, C.; Jennings, J.R.; Sheu, L.K.; Kuller, L.H.; Matthews, K.A.; Aizenstein, H.J.; Gianaros, P.J. Gain in adiposity across 15 years is associated with reduced gray matter volume in healthy women. Psychosom. Med. 2009, 71, 485-490.
61. Pedrini, S.; Thomas, C.; Brautigam, H.; Schmeidler, J.; Ho, L.; Fraser, P.; Westaway, D.; Hyslop, P.S.; Martins, R.N.; Buxbaum, J.D.; et al. Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology. Mol. Neurodegener. 2009, 4, 40.
62. Wang, P.W.; Sachs, G.S.; Zarate, C.A.; Marangell, L.B.; Calabrese, J.R.; Goldberg, J.F.; Sagduyu, K.; Miyahara, S.; Ketter, T.A. Overweight and obesity in bipolar disorders. J. Psychiatr. Res. 2006, 40, 762-764.
63. Fagiolini, A.; Frank, E.; Scott, J.A.; Turkin, S.; Kupfer, D.J. Metabolic syndrome in bipolar disorder: Findings from the Bipolar Disorder Center for Pennsylvanians. Bipolar Disord. 2005, 7, 424-430.
64. Fagiolini, A.; Frank, E.; Houck, P.R.; Mallinger, A.G.; Swartz, H.A.; Buysse, D.J.; Ombao, H.; Kupfer, D.J. Prevalence of obesity and weight change during treatment in patients with bipolar I disorder. J. Clin. Psychiatry 2002, 63, 528-533.
65. Fagiolini, A.; Kupfer, D.J.; Rucci, P.; Scott, J.A.; Novick, D.M.; Frank, E. Suicide attempts and ideation in patients with bipolar I disorder. J. Clin. Psychiatry 2004, 65, 509-514.
66. Fagiolini, A.; Kupfer, D.J.; Houck, P.R.; Novick, D.M.; Frank, E. Obesity as a correlate of outcome in patients with bipolar I disorder. Am. J. Psychiatry 2003, 160, 112-117.
67. Ogden, C.L.; Carroll, M.D.; Curtin, L.R.; McDowell, M.A.; Tabak, C.J.; Flegal, K.M. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006, 295, 1549-1555.
68. Katzmarzyk, P.T.; Craig, C.L.; Bouchard, C. Original article underweight, overweight and obesity: Relationships with mortality in the 13-year follow-up of the Canada Fitness Survey. J. Clin. Epidemiol. 2001, 54, 916-920.
69. Statistics Canada Health Indicators. Available online: http://www.statcan.gc.ca/ (accessed on 1 December 2006).
70. Kearney, P.M.; Whelton, M.; Reynolds, K.; Muntner, P.; Whelton, P.K.; He, J. Global burden of hypertension: Analysis of worldwide data. Lancet 2005, 365, 217-223.
71. Wilkins, K.; Campbell, N.R.; Joffres, M.R.; McAlister, F.A.; Nichol, M.; Quach, S.; Johansen, H.L.; Tremblay, M.S. Blood pressure in Canadian adults. Health Rep. 2010, 21, 37-46.
72. Ciranni, M.A.; Kearney, T.E.; Olson, K.R. Comparing acute toxicity of first-and second-generation antipsychotic drugs: A 10-year, retrospective cohort study. J. Clin. Psychiatry 2009, 70, 122-129.
73. Institute of Medicine (U.S.). A Population-Based Policy and Systems Change Approach to Prevent and Control Hypertension; National Academies Press: Washington, DC, USA, 2010.
74. Yano, K.; McGee, D.; Reed, D.M. The impact of elevated blood pressure upon 10-year mortality among Japanese men in Hawaii: The Honolulu Heart Program. J. Chronic Dis. 1983, 36, 569-579.
75. Wei, G.S.; Coady, S.A.; Goff, D.C., Jr.; Brancati, F.L.; Levy, D.; Selvin, E.; Vasan, R.S.; Fox, C.S. Blood Pressure and the Risk of Developing Diabetes in African Americans and Whites: ARIC, CARDIA, and the Framingham Heart Study. Diabetes Care 2011, 34, 873-879.
76. Jensen, M.T.; Marott, J.L.; Jensen, G.B. Elevated resting heart rate is associated with greater risk of cardiovascular and all-cause mortality in current and former smokers. Int. J. Cardiol. 2011, 151, 148-154.
77. Rogowski, O.; Steinvil, A.; Berliner, S.; Cohen, M.; Saar, N.; Ben-Bassat, O.K.; Shapira, I. Elevated resting heart rate is associated with the metabolic syndrome. Cardiovasc. Diabetol. 2009, 8, 55.
78. Casey, D.E. Dyslipidemia and atypical antipsychotic drugs. J. Clin. Psychiatry 2004, 65 (Suppl. 18), 27-35.
79. Colman, R.; Walker, S. The Cost of Physical Inactivity in British Columbia; Genuine Progress Index Atlantic: Victoria, Canada, 2004; p. 31.
80. Katzmarzyk, P.T.; Janssen, I. The economic costs associated with physical inactivity and obesity in Canada: An update. Can. J. Appl. Physiol. 2004, 29, 90-115.
81. Warburton, D.E.R.; Katzmarzyk, P.T.; Rhodes, R.E.; Shephard, R.J. Evidence-informed physical activity guidelines for Canadian adults. Appl. Physiol. Nutr. Metab. 2007, 32, S16-S68.
82. Ivy, J.L.; Zderic, T.W.; Fogt, D.L. Prevention and treatment of non-insulin-dependent diabetes mellitus. Exerc. Sport Sci. Rev. 1999, 27, 1-35.
83. Kriska, A.M.; Saremi, A.; Hanson, R.L.; Bennett, P.H.; Kobes, S.; Williams, D.E.; Knowler, W.C. Physical activity, obesity, and the incidence of type 2 diabetes in a high-risk population. Am. J. Epidemiol. 2003, 158, 669-675.
84. De Hert, M.; Vancampfort, D.; Correll, C.U.; Mercken, V.; Peuskens, J.; Sweers, K.; van Winkel, R.; Mitchell, A.J. Guidelines for screening and monitoring of cardiometabolic risk in schizophrenia: Systematic evaluation. Br. J. Psychiatry 2011, 199, 99-105.
85. Faulkner, G.; Taylor, A.; Munro, S.; Selby, P.; Gee, C. The acceptability of physical activity programming within a smoking cessation service for individuals with severe mental illness. Patient Educ. Couns. 2007, 66, 123-126.
86. Vancampfort, D.; Probst, M.; Sweers, K.; Maurissen, K.; Knapen, J.; de Hert, M. Relationships between obesity, functional exercise capacity, physical activity participation and physical self-perception in people with schizophrenia. Acta Psychiatr. Scand. 2011, 123, 423-430.
87. Xiong, G.; Ziegahn, L.; Schuyler, B.; Rowlett, A.; Cassady, D. Improving dietary and physical activity practices in group homes serving residents with severe mental illness. Prog. Community Health Partnersh. 2010, 4, 279-288.
88. Jerome, G.J.; Young, D.R.; Dalcin, A.; Charleston, J.; Anthony, C.; Hayes, J.; Daumit, G.L. Physical activity levels of persons with mental illness attending psychiatric rehabilitation programs. Schizophr. Res. 2009, 108, 252-257.
89. Daumit, G.L.; Goldberg, R.W.; Anthony, C.; Dickerson, F.; Brown, C.H.; Kreyenbuhl, J.; Wohlheiter, K.; Dixon, L.B. Physical activity patterns in adults with severe mental illness. J. Nerv. Ment. Dis. 2005, 193, 641-646.
90. Loitz, C.; Fraser, S.N.; Benegoechea, G.; Berry, T.R.; McGannon, K.R.; Spence, J.C. Sociodemographic patterns of leisure-time physical activity of Albertans 2000 to 2011. Health Fit. J. Can. 2012, 5, 3-15.
91. Ryan, M.C.; Flanagan, S.; Kinsella, U.; Keeling, F.; Thakore, J.H. The effects of atypical antipsychotics on visceral fat distribution in first episode, drug-naive patients with schizophrenia. Life Sci. 2004, 74, 1999-2008.
92. Warburton, D.E.; Taylor, A.; Bredin, S.S.; Esch, B.T.; Scott, J.M.; Haykowsky, M.J. Central haemodynamics and peripheral muscle function during exercise in patients with chronic heart failure. Appl. Physiol. Nutr. Metab. 2007, 32, 318-331.
93. Ussher, M.; Stanbury, L.; Cheeseman, V.; Faulkner, G. Physical activity preferences and perceived barriers to activity among persons with severe mental illness in the United Kingdom. Psychiatr. Serv. 2007, 58, 405-408.
94. Sallis, J.F. Progress in behavioral research on physical activity. Ann. Behav. Med. 2001, 23, 77-78.
95. Warburton, D.E.; Bredin, S.S.; Horita, L.T.; Zbogar, D.; Scott, J.M.; Esch, B.T.; Rhodes, R.E. The health benefits of interactive video game exercise. Appl. Physiol. Nutr. Metab. 2007, 32, 655-663.
96. Warburton, D.E.R.; Bredin, S.S.D. The importance of qualified exercise professionals in Canada. Health Fit. J. Can. 2009, 2, 18-22.
97. Warburton, D.E.R.; Bredin, S.S.D.; Charlesworth, S.; Foulds, H.; McKenzie, D.C.; Shephard, R.J. Evidence-based risk recommendations for best practices in the training of qualified exercise professionals working with clinical populations. Appl. Physiol. Nutr. Metab. 2011, 36, S232-S265.
98. Martin, J.L.; Perez, V.; Sacristan, M.; Rodriguez-Artalejo, F.; Martinez, C.; Alvarez, E. Meta-analysis of drop-out rates in randomised clinical trials, comparing typical and atypical antipsychotics in the treatment of schizophrenia. Eur. Psychiatry 2006, 21, 11-20.
99. Giacomantonio, N.B.; Bredin, S.S.; Foulds, H.J.; Warburton, D.E. A systematic review of the health benefits of exercise rehabilitation in persons living with atrial fibrillation. Can. J. Cardiol. 2013, 29, 483-491.
100. Howley, E.T. Type of activity: Resistance, aerobic and leisure versus occupational physical activity. Med. Sci. Sports Exerc. 2001, 33, S364-S369; discussion S419-S420.
101. Myers, J.; Kaykha, A.; George, S.; Abella, J.; Zaheer, N.; Lear, S.; Yamazaki, T.; Froelicher, V. Fitness versus physical activity patterns in predicting mortality in men. Am. J. Med. 2004, 117, 912-918.
102. Warren, K.R.; Ball, M.P.; Feldman, S.; Liu, F.; McMahon, R.P.; Kelly, D.L. Exercise program adherence using a 5-kilometer (5K) event as an achievable goal in people with schizophrenia. Biol. Res. Nurs. 2011, 13, 383-390.
103. Scheewe, T.W.; Backx, F.J.; Takken, T.; Jorg, F.; van Strater, A.C.; Kroes, A.G.; Kahn, R.S.; Cahn, W. Exercise therapy improves mental and physical health in schizophrenia: A randomised controlled trial. Acta Psychiatr. Scand. 2012, doi:10.1111/acps.12029.
104. Dodd, K.J.; Duffy, S.; Stewart, J.A.; Impey, J.; Taylor, N. A small group aerobic exercise programme that reduces body weight is feasible in adults with severe chronic schizophrenia: A pilot study. Disabil. Rehabil. 2011, 33, 1222-1229.
105. Pajonk, F.G.; Wobrock, T.; Gruber, O.; Scherk, H.; Berner, D.; Kaizl, I.; Kierer, A.; Muller, S.; Oest, M.; Meyer, T.; et al. Hippocampal plasticity in response to exercise in schizophrenia. Arch. Gen. Psychiatry 2010, 67, 133-143.
106. Vancampfort, D.; de Hert, M.; Skjerven, L.H.; Gyllensten, A.L.; Parker, A.; Mulders, N.; Nyboe, L.; Spencer, F.; Probst, M. International Organization of Physical Therapy in Mental Health consensus on physical activity within multidisciplinary rehabilitation programmes for minimising cardio-metabolic risk in patients with schizophrenia. Disabil. Rehabil. 2012, 34, 1-12.
107. Bredin, S.S.D.; Warburton, D.E.R. The Physical Activity Line: Effective knowledge translation of evidence-based best practice in the real world setting. Can. Fam. Physician 2013, in press.