-
1
-
-
80051989633
-
The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial
-
Cleland JG, Teerlink JR, Senior R, Nifontov EM, Mc Murray JJ, et al. (2011) The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial. Lancet 378: 676-683.
-
(2011)
Lancet
, vol.378
, pp. 676-683
-
-
Cleland, J.G.1
Teerlink, J.R.2
Senior, R.3
Nifontov, E.M.4
Mc Murray, J.J.5
-
2
-
-
4644292873
-
Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3
-
Gao MH, Tang T, Guo T, Sun SQ, Feramisco JR, et al. (2004) Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3. J Biol Chem 279: 38797-3802.
-
(2004)
J Biol Chem
, vol.279
, pp. 33802-38797
-
-
Gao, M.H.1
Tang, T.2
Guo, T.3
Sun, S.Q.4
Feramisco, J.R.5
-
3
-
-
57749094223
-
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes
-
Gao MH, Tang T, Guo T, Yajima T, Pestonjamasp K, et al. (2008) Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes. J Biol Chem 283: 33527-33535.
-
(2008)
J Biol Chem
, vol.283
, pp. 33527-33535
-
-
Gao, M.H.1
Tang, T.2
Guo, T.3
Yajima, T.4
Pestonjamasp, K.5
-
4
-
-
79951967856
-
Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant
-
Gao MH, Tang T, Lai NC, Yajima T, Miyanohara A, et al. (2011) Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant. Mol Pharmacol 79: 381-388.
-
(2011)
Mol Pharmacol
, vol.79
, pp. 381-388
-
-
Gao, M.H.1
Tang, T.2
Lai, N.C.3
Yajima, T.4
Miyanohara, A.5
-
5
-
-
37349042536
-
Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling
-
Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, et al. (2008) Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation 117: 61-69.
-
(2008)
Circulation
, vol.117
, pp. 61-69
-
-
Tang, T.1
Gao, M.H.2
Lai, N.C.3
Firth, A.L.4
Takahashi, T.5
-
6
-
-
33751277224
-
Adenylyl cyclase and G protein receptor kinase expression during development of heart failure
-
Ping P, Anzai T, Gao MH, Hammond HK, (1996) Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am J Physiol Heart Circ Physiol 273: H707-717.
-
(1996)
Am J Physiol Heart Circ Physiol
, vol.273
-
-
Ping, P.1
Anzai, T.2
Gao, M.H.3
Hammond, H.K.4
-
7
-
-
0037161374
-
Adenylyl cyclase increases survival in cardiomyopathy
-
Roth DM, Bayat H, Drumm JD, Gao MH, Swaney JS, et al. (2002) Adenylyl cyclase increases survival in cardiomyopathy. Circulation 105: 1989-1994.
-
(2002)
Circulation
, vol.105
, pp. 1989-1994
-
-
Roth, D.M.1
Bayat, H.2
Drumm, J.D.3
Gao, M.H.4
Swaney, J.S.5
-
8
-
-
33746206024
-
Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction
-
Takahashi T, Tang T, Lai NC, Roth DM, Rebolledo B, et al. (2006) Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation 114: 388-396.
-
(2006)
Circulation
, vol.114
, pp. 388-396
-
-
Takahashi, T.1
Tang, T.2
Lai, N.C.3
Roth, D.M.4
Rebolledo, B.5
-
9
-
-
3242660757
-
Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure
-
Lai NC, Roth DM, Gao MH, Tang T, Dalton N, et al. (2004) Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure. Circulation 110: 330-336.
-
(2004)
Circulation
, vol.110
, pp. 330-336
-
-
Lai, N.C.1
Roth, D.M.2
Gao, M.H.3
Tang, T.4
Dalton, N.5
-
10
-
-
0345120936
-
Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy
-
Roth DM, Gao MH, Lai NC, Drumm J, Dalton N, et al. (1999) Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. Circulation 99: 3099-3102.
-
(1999)
Circulation
, vol.99
, pp. 3099-3102
-
-
Roth, D.M.1
Gao, M.H.2
Lai, N.C.3
Drumm, J.4
Dalton, N.5
-
11
-
-
41549124900
-
Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice
-
Lai NC, Tang T, Gao MH, Saito M, Takahashi T, et al. (2008) Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice. J Am Coll Cardiol 51: 1490-1497.
-
(2008)
J Am Coll Cardiol
, vol.51
, pp. 1490-1497
-
-
Lai, N.C.1
Tang, T.2
Gao, M.H.3
Saito, M.4
Takahashi, T.5
-
12
-
-
7244219807
-
Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy
-
Tang T, Gao MH, Roth DM, Guo T, Hammond HK, (2004) Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy. Am J Physiol 287: H1906-1912.
-
(2004)
Am J Physiol
, vol.287
-
-
Tang, T.1
Gao, M.H.2
Roth, D.M.3
Guo, T.4
Hammond, H.K.5
-
13
-
-
0028987631
-
Overexpression of Gsα protein in the hearts of transgenic mice
-
Gaudin C, Ishikawa Y, Wight DC, Mahdavi V, Nadal-Ginard B, et al. (1995) Overexpression of Gsα protein in the hearts of transgenic mice. J Clin Invest 95: 1676-1683.
-
(1995)
J Clin Invest
, vol.95
, pp. 1676-1683
-
-
Gaudin, C.1
Ishikawa, Y.2
Wight, D.C.3
Mahdavi, V.4
Nadal-Ginard, B.5
-
14
-
-
0033535942
-
Progressive hypertrophy and heart failure in β1-adrenergic receptor transgenic mice
-
Engelhardt S, Hein L, Wiesmann F, Lohse MJ, (1999) Progressive hypertrophy and heart failure in β1-adrenergic receptor transgenic mice. Proc Natl Acad Sci 96: 7059-7064.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 7059-7064
-
-
Engelhardt, S.1
Hein, L.2
Wiesmann, F.3
Lohse, M.J.4
-
15
-
-
0034636061
-
Early and delayed consequences of β2-adrenergic receptor overexpression in mouse hearts: critical role for expression level
-
Liggett SB, Tepe NM, Lorenz JN, Canning AM, Jantz TD, et al. (2000) Early and delayed consequences of β2-adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation 101: 1707-1714.
-
(2000)
Circulation
, vol.101
, pp. 1707-1714
-
-
Liggett, S.B.1
Tepe, N.M.2
Lorenz, J.N.3
Canning, A.M.4
Jantz, T.D.5
-
16
-
-
0035941418
-
Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase A
-
Antos CL, Frey N, Marx SO, Reiken S, Gaburjakova M, et al. (2001) Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase A. Circ Res 89: 997-1004.
-
(2001)
Circ Res
, vol.89
, pp. 997-1004
-
-
Antos, C.L.1
Frey, N.2
Marx, S.O.3
Reiken, S.4
Gaburjakova, M.5
-
17
-
-
0026072848
-
Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group
-
Packer M, Carver JR, Rodeheffer RJ, Ivanhoe RJ, Dibianco R, et al. (1991) Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N Engl J Med 325: 1468-1475.
-
(1991)
N Engl J Med
, vol.325
, pp. 1468-1475
-
-
Packer, M.1
Carver, J.R.2
Rodeheffer, R.J.3
Ivanhoe, R.J.4
Dibianco, R.5
-
18
-
-
0019982539
-
Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts
-
Bristow MR, Ginsburg R, Minobe W, Cubicciotti RS, Sageman WS, et al. (1982) Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. N Engl J Med 307: 205-211.
-
(1982)
N Engl J Med
, vol.307
, pp. 205-211
-
-
Bristow, M.R.1
Ginsburg, R.2
Minobe, W.3
Cubicciotti, R.S.4
Sageman, W.S.5
-
19
-
-
57349150202
-
Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy
-
Suarez J, Scott B, Dillmann WH, (2008) Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy. Am J Physiol 295: R1439-1445.
-
(2008)
Am J Physiol
, vol.295
-
-
Suarez, J.1
Scott, B.2
Dillmann, W.H.3
-
20
-
-
0034509410
-
Phospholamban and cardiac contractile function
-
Brittsan AG, Kranias EG, (2000) Phospholamban and cardiac contractile function. J Mol Cell Cardiol 32: 2131-2139.
-
(2000)
J Mol Cell Cardiol
, vol.32
, pp. 2131-2139
-
-
Brittsan, A.G.1
Kranias, E.G.2
-
21
-
-
0034623718
-
A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta-agonists
-
Chu G, Lester JW, Young KB, Luo W, Zhai J, et al. (2000) A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta-agonists. J Biol Chem 275: 38938-38943.
-
(2000)
J Biol Chem
, vol.275
, pp. 38938-38943
-
-
Chu, G.1
Lester, J.W.2
Young, K.B.3
Luo, W.4
Zhai, J.5
-
22
-
-
0032548847
-
Transgenic approaches to define the functional role of dual site phospholamban phosphorylation
-
Luo W, Chu G, Sato Y, Zhou Z, Kadambi VJ, et al. (1998) Transgenic approaches to define the functional role of dual site phospholamban phosphorylation. J Biol Chem 273: 4734-4739.
-
(1998)
J Biol Chem
, vol.273
, pp. 4734-4739
-
-
Luo, W.1
Chu, G.2
Sato, Y.3
Zhou, Z.4
Kadambi, V.J.5
-
23
-
-
0026071499
-
CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
-
Foulkes NS, Borrelli E, Sassone-Corsi P, (1991) CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64: 739-749.
-
(1991)
Cell
, vol.64
, pp. 739-749
-
-
Foulkes, N.S.1
Borrelli, E.2
Sassone-Corsi, P.3
-
24
-
-
0141668955
-
Transgenic overexpression of the Ca2+ -binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance
-
Most P, Remppis A, Pleger ST, Löffler E, Ehlermann P, et al. (2003) Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance. J Biol Chem 278: 33809-33817.
-
(2003)
J Biol Chem
, vol.278
, pp. 33809-33817
-
-
Most, P.1
Remppis, A.2
Pleger, S.T.3
Löffler, E.4
Ehlermann, P.5
-
25
-
-
0035430282
-
Transcriptional regulation by the phosphorylation-dependent factor CREB
-
Mayr B, Montminy M, (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2: 599-609.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 599-609
-
-
Mayr, B.1
Montminy, M.2
-
26
-
-
0029937002
-
Expression of the rat S100A1 gene in neurons, glia, and skeletal muscle
-
Song W, Zimmer DB, (1996) Expression of the rat S100A1 gene in neurons, glia, and skeletal muscle. Brain Res 721: 204-216.
-
(1996)
Brain Res
, vol.721
, pp. 204-216
-
-
Song, W.1
Zimmer, D.B.2
-
27
-
-
54249163411
-
Spatial and temporal aspects of cAMP signaling in cardiac myocytes
-
Iancu RV, Ramamurthy G, Harvey RD, (2008) Spatial and temporal aspects of cAMP signaling in cardiac myocytes. Clin Exp Pharmacol Physiol 35: 1343-1348.
-
(2008)
Clin Exp Pharmacol Physiol
, vol.35
, pp. 1343-1348
-
-
Iancu, R.V.1
Ramamurthy, G.2
Harvey, R.D.3
-
28
-
-
77951985322
-
AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and AC6 to α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors
-
Efendiev R, Samelson BK, Nguyen BT, Phatarpekar PV, Baameur F, et al. (2010) AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and AC6 to α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors. J Biol Chem 285: 14450-14458.
-
(2010)
J Biol Chem
, vol.285
, pp. 14450-14458
-
-
Efendiev, R.1
Samelson, B.K.2
Nguyen, B.T.3
Phatarpekar, P.V.4
Baameur, F.5
-
29
-
-
0033943654
-
Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving Gs
-
Ostrom RS, Post SR, Insel PA, (2000) Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving Gs. J Pharmacol Exp Ther 294: 407-412.
-
(2000)
J Pharmacol Exp Ther
, vol.294
, pp. 407-412
-
-
Ostrom, R.S.1
Post, S.R.2
Insel, P.A.3
-
30
-
-
0003218037
-
Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice
-
Gao MH, Lai NC, Roth DM, Zhou J, Zhu J, et al. (1999) Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice. Circulation 99: 1618-1622.
-
(1999)
Circulation
, vol.99
, pp. 1618-1622
-
-
Gao, M.H.1
Lai, N.C.2
Roth, D.M.3
Zhou, J.4
Zhu, J.5
|