The role of RUNX1 isoforms in hematopoietic commitment of human pluripotent stem cells

Blood

Volumn 121, Issue 6, 2013, Pages 5250-5252

  Real, Pedro J ^a   Navarro Montero, Oscar ^a   Ramos Mejía, Verónica ^a   Ayllón, Verónica ^a   Bueno, Clara ^a   Menéndez, Pablo ^a,b  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; TRANSCRIPTION FACTOR RUNX1;

ENGRAFTMENT; HEMATOPOIESIS; HUMAN; HUMAN CELL; LETTER; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEM CELL SELF-RENEWAL; EMBRYONIC STEM CELL; HEMATOPOIETIC STEM CELL; METABOLISM; NOTE;

CORE BINDING FACTOR ALPHA 2 SUBUNIT; EMBRYONIC STEM CELLS; HEMATOPOIETIC STEM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS;

EID: 84884187885     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-03-487587     Document Type: Letter

References (14)

1. Ran D, Shia WJ, Lo MC, et al. RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells. Blood. 2013;121(15):2882-2890.
2. Lam K, Zhang DE. RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis. Front Biosci. 2012;17:1120-1139.
3. Real PJ, Ligero G, Ayllon V, et al. SCL/TAL1 regulates hematopoietic specification from human embryonic stem cells. Mol Ther. 2012;20(7):1443-1453.
4. Challen GA, Goodell MA. Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells. Exp Hematol. 2010;38(5):403-416.
5. Mikhail FM, Serry KA, Hatem N, et al. AML1 gene over-expression in childhood acute lymphoblastic leukemia. Leukemia. 2002;16(4):658-668.
6. Niini T, Vettenranta K, Hollmén J, et al. Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia - a cDNA array study. Leukemia. 2002;16(11):2213-2221.
7. Wilkinson AC, Ballabio E, Geng H, et al. RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction. Cell Rep. 2013;3(1):116-127.
8. Blyth K, Cameron ER, Neil JC. The RUNX genes: gain or loss of function in cancer. Nat Rev Cancer. 2005;5(5):376-387.
9. Liu X, Zhang Q, Zhang DE, et al. Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis. Leukemia. 2009;23(4):739-745.
10. Okuda T, Takeda K, Fujita Y, et al. Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy. Mol Cell Biol. 2000;20(1):319-328.
11. Mangan JK, Speck NA. RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making. Crit Rev Oncog. 2011;16(1-2):77-91.
12. Werbowetski-Ogilvie TE, Bossé M, Stewart M, et al. Characterization of human embryonic stem cells with features of neoplastic progression. Nat Biotechnol. 2009;27(1):91-97.
13. Tsuzuki S, Hong D, Gupta R, Matsuo K, Seto M, Enver T. Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1. PLoS Med. 2007;4(5):e172.
14. Navarro-Montero O, Romero-Moya D, Montes R, et al. Intrahepatic transplantation of cord blood CD34+ cells into newborn NOD/SCID-IL2Rγ(null) mice allows efficient multi-organ and multi-lineage hematopoietic engraftment without accessory cells. Clin Immunol. 2012;145(2):89-91.