Intrahepatic transplantation of cord blood CD34+ cells into newborn NOD/SCID-IL2Rγnull mice allows efficient multi-organ and multi-lineage hematopoietic engraftment without accessory cells

Clinical Immunology

Volumn 145, Issue 2, 2012, Pages 89-91

  Navarro Montero, Oscar ^a   Romero Moya, Damià ^a   Montes, Rosa ^a   Ramos Mejía, Verónica ^a   Bueno, Clara ^a   Real, Pedro J ^a   Menendez, Pablo ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN;

ALLOTRANSPLANTATION; CORD BLOOD STEM CELL TRANSPLANTATION; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LETTER; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANIMALS, NEWBORN; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD34; CELL LINEAGE; CORD BLOOD STEM CELL TRANSPLANTATION; FETAL BLOOD; GAMMA RAYS; GRAFT SURVIVAL; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; LIVER; MICE; MICE, INBRED NOD; MICE, SCID; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84865828438     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2012.08.001     Document Type: Letter

References (11)

1. Dick J.E., Bhatia M., Gan O., Kapp U., Wang J.C. Assay of human stem cells by repopulation of NOD/SCID mice. Stem Cells 1997, 15:199-203.
2. Shultz L.D., Ishikawa F., Greiner D.L. Humanized mice in translational biomedical research. Nat. Rev. Immunol. 2007, 7:118-130.
3. Levac K., Menendez P., Bhatia M. Intra-bone marrow transplantation facilitates pauci-clonal human hematopoietic repopulation of NOD/SCID/beta2m(-/-) mice. Exp. Hematol. 2005, 33:1417-1426.
4. Bueno C., Montes R., de la Cueva T., Gutierrez-Aranda I., Menendez P. Intra-bone marrow transplantation of human CD34(+) cells into NOD/LtSz-scid IL-2rgamma(null) mice permits multilineage engraftment without previous irradiation. Cytotherapy 2010, 12:45-49.
5. Shultz L.D., Lyons B.L., Burzenski L.M., Gott B., Chen X., Chaleff S., et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J. Immunol. 2005, 174:6477-6489.
6. Urbano-Ispizua A., Carreras E., Marin P., Rovira M., Martinez C., Fernandez-Aviles F., et al. Allogeneic transplantation of CD34(+) selected cells from peripheral blood from human leukocyte antigen-identical siblings: detrimental effect of a high number of donor CD34(+) cells?. Blood 2001, 98:2352-2357.
7. Kawabata Y., Hirokawa M., Komatsuda A., Sawada K. Clinical applications of CD34+ cell-selected peripheral blood stem cells. Ther. Apher. Dial. 2003, 7:298-304.
8. Mattsson J., Ringden O., Storb R. Graft failure after allogeneic hematopoietic cell transplantation. Biol. Blood Marrow Transplant. 2008, 14:165-170.
9. Platzbecker U., Ehninger G., Bornhauser M. Allogeneic transplantation of CD34+ selected hematopoietic cells-clinical problems and current challenges. Leuk. Lymphoma 2004, 45:447-453.
10. Urbano-Ispizua A., Rozman C., Pimentel P., Solano C., de la Rubia J., Brunet S., et al. The number of donor CD3+ cells is the most important factor for graft failure after allogeneic transplantation of CD34+ selected cells from peripheral blood from HLA-identical siblings. Blood 2001, 97:383-387.
11. Traggiai E., Chicha L., Mazzucchelli L., Bronz L., Piffaretti J.C., Lanzavecchia A., et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 2004, 304:104-107.