A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism

Journal of Biological Chemistry

Volumn 288, Issue 37, 2013, Pages 26635-26648

  Hinkofer, Lisa C ^a   Seidel, Susanne A I ^a   Korkmaz, Brice ^a,b   Silva, Francisco ^c,e   Hummel, Amber M ^a   Braun, Dieter ^b   Jenne, Dieter E ^a,d   Specks, Ulrich ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b Université Franaois Rabelais   (France)

^c MAYO CLINIC   (United States)

^d MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^e PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MECHANISMS; ELASTASE; PROTEINASE 3; SELECTIVE INHIBITORS; SERINE PROTEASE; VASCULITIS;

AMINO ACIDS;

MONOCLONAL ANTIBODIES;

ALPHA 1 ANTITRYPSIN; ANILIDE; ENZYME PRECURSOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MCPR3 7; MYELOBLASTIN; PROTEIN VARIANT; RECOMBINANT PROTEIN; THIOESTER; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG TARGETING; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

Α1-PROTEINASE INHIBITOR; ALLOSTERY; ANTIBODIES; AUTOIMMUNITY; NEUTROPHIL; PROTEASE; PROTEASE INHIBITOR; PROTEINASE 3; THERMOPHORESIS; ZYMOGEN;

ALLOSTERIC SITE; ANIMALS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIBODIES, MONOCLONAL; AUTOIMMUNITY; CATALYSIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEK293 CELLS; HUMANS; MICE; MICE, INBRED BALB C; MYELOBLASTIN; NEUTROPHIL ACTIVATION; NEUTROPHILS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; VASCULITIS;

EID: 84884185457     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.495770     Document Type: Article

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