Effects of dietary components on testosterone metabolism via UDP-glucuronosyltransferase

Frontiers in Endocrinology

Volumn 4, Issue JUL, 2013, Pages

  Jenkinson, Carl ^a   Petroczi, Andrea ^a   Naughton, Declan P ^a  

^a KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

Catechins; Flavonoids; Glucuronidation; Green tea; Inhibition; Red wine; Testosterone; UGT2B17

Indexed keywords

CATECHIN; DICLOFENAC; EPICATECHIN; EPIGALLOCATECHIN GALLATE; EPITESTOSTERONE; FLAVONOID; GLUCURONOSYLTRANSFERASE; IBUPROFEN; QUERCETIN; TESTOSTERONE;

DIET; DRUG CONTRAINDICATION; DRUG METABOLISM; ENDOCRINE DISEASE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; GLUCURONIDATION; HUMAN; IN VITRO STUDY; MICROSOME; PATHOLOGY; PROSTATE CANCER; QUANTITATIVE ANALYSIS; RED WINE; SHORT SURVEY; STEROID METABOLISM; TEA; TESTOSTERONE METABOLISM;

EID: 84884184654     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2013.00080     Document Type: Short Survey

References (23)

1. Angstadt AY, Berg A, Zhu J, Miller P, Hartman TJ, Lesko SM, et al. The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk. Cancer (2013) 119:2477-85. doi:10.1002/cncr.28009
2. Thind J, Jenkinson C, Naughton DP, Petroczi A. Modulation of UDP glucuronosyltransferase 2B15 and 2B17 and prostate cancer risk. Curr Perspect Adv Cancer Res Treat (2013) 2013:812129. doi:10.5171/2013.812129
3. Saracino MR, Lampe JW. Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention. Nutr Cancer (2007) 59:121-41. doi:10.1080/01635580701458178
4. Zhong Y, Byrd JC. UGT2B17 as a disease accelerator in CLL. Blood (2012) 121:1067-8. doi:10.1182/blood-2012-12-469965
5. Ekström L, Gök E, Johansson M, Garle M, Rane A, Schulze JJ. Doping and genetic testing: sex difference in UGT2B15 expression, testosterone glucuronidation activity and urinary testosterone/epitestosterone glucuronide ratio. Curr Pharmacogenomics Person Med (2012) 10:125-31. doi:10.2174/187569212800626403
6. Mizuma T, Awazu S. Dietary polyphenols (-)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption. J Pharm Sci (2004) 93:2407-10. doi:10.1002/jps.20146
7. Van der Logt EMJ, Roelofs HMJ, Nagengast FM, Peters WHM. Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens. Carcinogenesis (2003) 24:1651-6. doi:10.1093/carcin/bgg117
8. Van der Logt EMJ, Roelof HMJ, Van Lieshout EMM, Nagengast FM, Peters WHM. Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases. Anticancer Res (2004) 24: 843-9.
9. Grancharov K, Engelberg H, Naydenova Z, Müller G, Rettenmeier AW, Golovinsky E. Inhibition of UDP-glucuronosyltransferases in rat liver microsomes by natural mutagens and carcinogens. Arch Toxicol (2001) 75:609-12. doi:10.1007/s00204-001-0282-x
10. Teyssier C, Amiot M-J, Mondy N, Auger J, Kahane R, Siess MH. Effect of onion consumption by rats on hepatic drug-metabolizing enzymes. Food Chem Toxicol (2001) 39:981-7. doi:10.1016/S0278-6915(01)00056-4
11. Zhu BT, Taneja N, Loder DP, Balentine DA, Conney AH. Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estrone. J Steroid Biochem Mol Biol (1998) 64:207-15. doi:10.1016/S0960-0760(97)00163-5
12. Rathbun RC, Liedtke MD. Antiretroviral drug interactions: overview of interactions involving new and investigational agents and the role of therapeutic drug monitoring for management. Pharmaceutics (2011) 3:745-81. doi:10.3390/pharmaceutics3040745
13. Wacher VJ, Benet LZ. Use of UGT Inhibitors to Increase Bioavailability. US Patent Application WO03055494A1 (2003).
14. Sten T, Bichlmaier I, Kuuranne T, Leinonen A, Yli-Kauhaluoma J, Finel M. UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly. Drug Metab Dispos (2009) 37:417-23. doi:10.1124/dmd.108.024844
15. Sten T, Finel M, Ask B, Rane A, Ekström L. Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation. Steroids (2009) 74:971-7. doi:10.1016/j.steroids.2009.07.004
16. Lundmark J, Gårevik N, Thörngren JO, Garle M, Ekström L, Rane A, et al. Nonsteroidal anti-inflammatory drugs (NSAIDs) do not influence the urinary testosterone/epitestosterone glucuronide ratio. Front Endocrinol (Lausanne) (2013) 4:51. doi:10.3389/fendo.2013.00051
17. Jenkinson C, Petroczi A, Barker J, Naughton DP. Dietary green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation. Steroids (2012) 77:691-5. doi:10.1016/j.steroids.2012.02.023
18. Jenkinson C, Petroczi A, Barker J, Naughton DP. Effects of food components and the ratio of epitestosterone to testosterone on steroid glucuronidation. Endocrine Abstracts (2013) 32:974. doi:10.1530/endoabs.32.P974
19. Jenkinson C, Petroczi A, Naughton DP. Red wine and component flavonoids inhibit UGT2B17 in vitro. Nutr J (2012) 11:67. doi:10.1186/1475-2891-11-67
20. Satoh K, Sakamoto Y, Ogata A, Nagai F, Mikuriya H, Numazawa M, et al. Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats. Food Chem Toxicol (2002) 40:925-33. doi:10.1016/S0278-6915(02)00066-2
21. Kao YH, Hiipakka RA, Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology (2000) 141:980-7. doi:10.1210/en.141.3.980
22. Chung LY, Cheung TC, Kong SK, Fung KP, Choy YM, Chan ZY, et al. Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. Life Sci (2001) 68:1207-14. doi:10.1016/S0024-3205(00)01020-1
23. Turgeon D, Carrier JS, Chouinard S, Bélanger A. Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics. Drug Metab Dispos (2003) 31:670-6. doi:10.1124/dmd.31.5.670