UGT2B17 as a disease accelerator in CLL

Blood

Volumn 121, Issue 7, 2013, Pages 1067-1068

  Zhong, Yiming ^a   Byrd, John C ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CD86 ANTIGEN; CYCLOPHOSPHAMIDE; GLUCURONOSYLTRANSFERASE; IMMUNOGLOBULIN HEAVY CHAIN; MESSENGER RNA; NOTCH1 RECEPTOR; PROTEIN KINASE ZAP 70; PROTEIN P53; RITUXIMAB; RNA; TUMOR MARKER; UNCLASSIFIED DRUG; URIDINE DIPHOSPHO GLUCURONOSYLTRANSFERASE 2B17;

B LYMPHOCYTE; CANCER CELL; CANCER GROWTH; CANCER PROGNOSIS; CATALYSIS; CHRONIC LYMPHATIC LEUKEMIA; GENE MUTATION; GLUCURONIDATION; HIGH RISK PATIENT; HUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 84874038927     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-12-469965     Document Type: Note

References (7)

1. Gruber M, Bellemare J, Hoermann G, et al. Overex-pression of uridine diphospho glucuronosyltransferase 2B17 in high risk chronic lymphocytic leukemia. Blood. 2013;121(7):1175-1183.
2. Gaidano G, Foa R, Dalla-Favera R. Molecular patho-genesis of chronic lymphocytic leukemia. J Clin Invest. 2012;122(10):3432-3438.
3. Wang L, Lawrence MS, Wan Y, et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011;365(26):2497-2506.
4. Schulze JJ, Thorngren JO, Garle M, Ekstrom L, Rane A. Androgen sulfation in healthy UDP-glucuronosyl transferase 2B17 enzyme-deficient men. J Clin Endocrinol Metab. 2011; 96(11):3440-3447.
5. Turgeon D, Carrier JS, Chouinard S, Belanger A. Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics. Drug Metab Dispos. 2003;31(5):670-676. (Pubitemid 36444177)
6. Jenkinson C, Petroczi A, Barker J, Naughton DP. Dietary green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation. Steroids. 2012;77(6):691-695.
7. Jenkinson C, Petroczi A, Naughton DP. Red wine and component flavonoids inhibit UGT2B17 in vitro. Nutr J. 2012;11:67.