The Trade-Off between Accuracy and Accessibility of Syphilis Screening Assays

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Smit, Pieter W ^a   Mabey, David ^a   Changalucha, John ^b   Mngara, Julius ^b   Clark, Benjamin ^b   Andreasen, Aura ^a,c   Todd, Jim ^a,b   Urassa, Mark ^b   Zaba, Basia ^a   Peeling, Rosanna W ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (Tanzania)

^c National Institute for Medical Research   (Tanzania)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLUTINATION TEST; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC KIT; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME IMMUNOASSAY; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEMALE; HEALTH CARE ACCESS; HEALTH CARE FACILITY; HUMAN; NONHUMAN; POINT OF CARE TESTING; PREGNANT WOMAN; PRENATAL CARE; REAGIN TEST; SCREENING TEST; SENSITIVITY AND SPECIFICITY; SYPHILIS; TANZANIA; TREPONEMA PALLIDUM;

FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; PREGNANCY; SENSITIVITY AND SPECIFICITY; SYPHILIS; TANZANIA; TREPONEMA PALLIDUM;

EID: 84884182819     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075327     Document Type: Article

References (29)

1. Chico RM, Mayaud P, Ariti C, Mabey D, Ronsmans C, et al. (2012) Prevalence of malaria and sexually transmitted and reproductive tract infections in pregnancy in sub-Saharan Africa: a systematic review. JAMA 307: 2079-2086. doi:10.1001/jama.2012.3428. PubMed: 22665107.
2. Watson-Jones D, Changalucha J, Gumodoka B, Weiss H, Rusizoka M, et al. (2002) Syphilis in pregnancy in Tanzania. I. Impact of maternal syphilis on outcome of pregnancy. J Infect Dis 186: 940-947.
3. WHO (2012) Investment case for eliminating mother-to-child transmission of syphilis. Geneva: World Health Organization.
4. Newman L, Kamb M, Hawkes S, Gomez G, Say L, et al. (2013) Global estimates of syphilis in pregnancy and associated adverse outcomes: analysis of multinational antenatal surveillance data. PLOS Med 10: e1001396. PubMed: 23468598.
5. Kingston M, French P, Goh B, Goold P, Higgins S, et al. (2008) UK National Guidelines on the Management of Syphilis 2008. Int J STD AIDS 19: 729-740. doi:10.1258/ijsa.2008.008279. PubMed: 18931264.
6. Tsang RS, Martin IE, Lau A, Sawatzky P, (2007) Serological diagnosis of syphilis: comparison of the Trep-Chek IgG enzyme immunoassay with other screening and confirmatory tests. FEMS Immunol Med Microbiol 51: 118-124. doi:10.1111/j.1574-695X.2007.00289.x. PubMed: 17854473.
7. Aktas G, Young H, Moyes A, Badur S, (2005) Evaluation of the serodia Treponema pallidum particle agglutination, the Murex Syphilis ICE and the Enzywell TP tests for serodiagnosis of syphilis. Int J STD AIDS 16: 294-298. doi:10.1258/0956462053654195. PubMed: 15899082.
8. Mabey D, Peeling RW, Ballard R, Benzaken AS, Galbán E, et al. (2006) Prospective, multi-centre clinic-based evaluation of four rapid diagnostic tests for syphilis. Sex Transm Infect 82 (Suppl 5): v13-6: v13-16. PubMed: 17215274.
9. Binnicker MJ, Jespersen DJ, Rollins LO, (2011) Treponema-specific tests for serodiagnosis of syphilis: comparative evaluation of seven assays. J Clin Microbiol 49: 1313-1317. doi:10.1128/JCM.02555-10. PubMed: 21346050.
10. Aktas G, Young H, Moyes A, Badur S, (2007) Evaluation of the fluorescent treponemal antibody absorption test for detection of antibodies (immunoglobulins G and M) to Treponema pallidum in serologic diagnosis of syphilis. Int J STD AIDS 18: 255-260. doi:10.1258/095646207780658827. PubMed: 17509177.
11. Young H, Pryde J, Duncan L, Dave J, (2009) The Architect Syphilis assay for antibodies to Treponema pallidum: an automated screening assay with high sensitivity in primary syphilis. Sex Transm Infect 85: 19-23. doi:10.1136/sti.2008.031872. PubMed: 18790859.
12. Maple PA, Ratcliffe D, Smit E, (2010) Characterization of Treponema pallidum particle agglutination assay-negative sera following screening by treponemal total antibody enzyme immunoassays. Clin Vaccine Immunol 17: 1718-1722. doi:10.1128/CVI.00102-10. PubMed: 20844087.
13. TAZAMA (2011) Tazama project. pp. Available: http://www.tazamaproject. org/pub0006.shtml. Accessed 2011 June 10.
14. Cawley C, Wringe A, Isingo R, Mtenga B, Clark B, et al. (2013) Low rates of repeat HIV testing despite increased availability of antiretroviral therapy in rural Tanzania: findings from 2003-2010. PLOS ONE 8: e62212. doi:10.1371/journal.pone.0062212. PubMed: 23626791.
15. Wambura M, Urassa M, Isingo R, Ndege M, Marston M, et al. (2007) HIV prevalence and incidence in rural Tanzania: results from 10 years of follow-up in an open-cohort study. J Acquir Immune Defic Syndr 46: 616-623. doi:10.1097/QAI.0b013e31815a571a. PubMed: 18043316.
16. Jafari Y, Peeling RW, Shivkumar S, Claessens C, Joseph L, et al. (2013) Are Treponema pallidum specific rapid and point-of-care tests for syphilis accurate enough for screening in resource limited settings? Evidence from a meta-analysis. PLOS ONE 8: e54695. doi:10.1371/journal.pone.0054695. PubMed: 23468842.
17. Mabey DC, Sollis KA, Kelly HA, Benzaken AS, Bitarakwate E, et al. (2012) Point-of-Care Tests to Strengthen Health Systems and Save Newborn Lives: The Case of Syphilis. PLOS Med 9: e1001233. PubMed: 22719229.
18. Schmid G, (2004) Economic and programmatic aspects of congenital syphilis prevention. Bull World Health Organ 82: 402-409. PubMed: 15356931.
19. Augenbraun MH, DeHovitz JA, Feldman J, Clarke L, Landesman S, et al. (1994) Biological false-positive syphilis test results for women infected with human immunodeficiency virus. Clin Infect Dis 19: 1040-1044. doi:10.1093/clinids/19.6.1040. PubMed: 7888531.
20. Oboho IK, Gebo KA, Moore RD, Ghanem KG, (2013) The Impact of Combined Antiretroviral Therapy on Biologic False Positive Rapid Plasma Reagin (RPR) Serologies in a Longitudinal Cohort of HIV-infected Persons. Clin Infect Dis.
21. Everett DB, Weiss HA, Changalucha J, Anemona A, Chirwa T, et al. (2007) Low specificity of the Murex fourth-generation HIV enzyme immunoassay in Tanzanian adolescents. Trop Med Int Health 12: 1323-1326. doi:10.1111/j.1365-3156.2007.01933.x. PubMed: 17949396.
22. Gasasira AF, Dorsey G, Kamya MR, Havlir D, Kiggundu M, et al. (2006) False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria. J Clin Microbiol 44: 3021-3024. doi:10.1128/JCM.02207-05. PubMed: 16891532.
23. Smit PW, van der Vlis T, Mabey D, Changalucha J, Mngara J, et al. (2013) The development and validation of dried blood spots for external quality assurance of syphilis serology. BMC Infect Dis MS ID, 13: 1470439142778761. PubMed: 23442198.
24. Dorigo-Zetsma JW, Belewu D, Meless H, Sanders E, Coutinho RA, et al. (2004) Performance of routine syphilis serology in the Ethiopian cohort on HIV/AIDS. Sex Transm Infect 80: 96-99. doi:10.1136/sti.2003.005827. PubMed: 15054167.
25. Mishra S, Naik B, Venugopal B, Kudur P, Washington R, et al. (2010) Syphilis screening among female sex workers in Bangalore, India: comparison of point-of-care testing and traditional serological approaches. Sex Transm Infect 2009/12/08:: 193-8 ed. pp. 193-198 PubMed: 19965800.
26. Gift TL, Pate MS, Hook EW 3rd, Kassler WJ, (1999) The rapid test paradox: when fewer cases detected lead to more cases treated: a decision analysis of tests for Chlamydia trachomatis. Sex Transm Dis 26: 232-240. doi:10.1097/00007435-199904000-00010. PubMed: 10225593.
27. Temmerman M, Gilks CF, Sanghri HC, (1993) Spontaneous and induced abortions at Kenyatta National Hospital, Nairobi, Kenya. Int J Gynecol Obstet 41: 182-183. doi:10.1016/0020-7292(93)90703-Y. PubMed: 8099035.
28. Fonck K, Claeys P, Bashir F, Bwayo J, Fransen L, et al. (2001) Syphilis control during pregnancy: effectiveness and sustainability of a decentralized program. Am J Public Health 91: 705-707. doi:10.2105/AJPH.91.5.705. PubMed: 11344874.
29. Bronzan RN, Mwesigwa-Kayongo DC, Narkunas D, Schmid GP, Neilsen GA, et al. (2007) On-site rapid antenatal syphilis screening with an immunochromatographic strip improves case detection and treatment in rural South African clinics. Sex Transm Dis 34: S55-S60. doi:10.1097/01.olq.0000245987.78067.0c. PubMed: 17139234.