The impact of combined antiretroviral therapy on biologic false-positive rapid plasma reagin serologies in a longitudinal cohort of HIV-infected persons

Clinical Infectious Diseases

Volumn 57, Issue 8, 2013, Pages 1197-1202

  Oboho, Ikwo K ^a   Gebo, Kelly A ^a   Moore, Richard D ^a   Ghanem, Khalil G ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antiretroviral therapy; false positive RPR; HIV

Indexed keywords

ANTIRETROVIRUS AGENT; REAGINIC ANTIBODY; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS RNA;

ADULT; AGE DISTRIBUTION; ANTIBODY TITER; ANTIVIRAL THERAPY; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ACTIVITY; DRUG USE; FALSE POSITIVE RESULT; FEMALE; FLUORESCENT TREPONEMA ANTIBODY TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEROLOGY; SYPHILIS;

ANTIRETROVIRAL THERAPY; FALSE-POSITIVE RPR; HIV;

ADULT; ANTI-RETROVIRAL AGENTS; COHORT STUDIES; DRUG THERAPY, COMBINATION; FALSE POSITIVE REACTIONS; FEMALE; HIV INFECTIONS; HUMANS; LOGISTIC MODELS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; ODDS RATIO; REAGINS; RETROSPECTIVE STUDIES; SYPHILIS; SYPHILIS SERODIAGNOSIS;

EID: 84884178486     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cit445     Document Type: Conference Paper

References (25)

1. Hook EW III, Marra CM. Acquired syphilis in adults. N Engl J Med 1992; 326:1060.
2. Moore JE, Moh CF. Biologically false positive serologic tests for syphilis; type, incidence, and cause. J Am Med Assoc 1952; 150:467-73.
3. Catteral RD. Presidential address to the MSSVD. Systemic diseases and the biological false positive reaction. Br J Vener Disease Dis 1972; 4:1-12.
4. Geusau A, Kittler H, Hein U, et al. Biological false-positive tests comprise a high proportion of Venereal Disease Research Laboratory reactions in an analysis of 300,000 sera. Int J STD AIDS 2005; 16:722-6. (Pubitemid 41659529)
5. Thomas DL, Rompalo AM, Zenilman J, et al. Association of hepatitis C virus infection with false positive tests for syphilis. J Infec Disease 1994; 170:1579-981.
6. Erbelding EJ, Vlahov D, Nelson KE, et al. Syphilis serology in human immunodeficiency virus infection: evidence for false-negative fluorescent treponemal testing. J Infect Dis 1997; 176:1397-400. (Pubitemid 27461012)
7. Rompalo AM, Cannon RO, Quinn TC, et al. Association of biologic false-positive reactions for syphilis with human immunodeficiency virus infection. J Infect Dis 1992; 165:1124-6.
8. Lane HC, Masur H, Edgar IC, et al. Abnormalities of B-cell activation and immunoregulation in patients with immunodeficiency syndrome. N Engl J Med 1983; 309:453-8. (Pubitemid 13041485)
9. Gray ES, Taylor N, Wycuff D, et al. Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donors. J Virol 2009; 83:8925-37.
10. Haynes BF, Fleming J, St Clair EW, et al. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science 2005; 308:1906-8. (Pubitemid 40941873)
11. Moore RD. Understanding the clinical and economic outcomes of HIV therapy; the Johns Hopkins HIV clinical practice cohort. J Acquir Immune Defic Syndr Human Retrovirol 1998; 17(suppl 1):38-41.
12. De Milito A. B lymphocyte dysfunctions in HIV infection. Curr HIV Res 2004; 2:11-21. (Pubitemid 38854921)
13. Moir S, Fauci AS. Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease. J Allergy Clin Immunol 2008; 122:12-9.
14. Morris L, Binley JM, Clas BA, et al. HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy. J Exp Med 1998; 188:233-45. (Pubitemid 28357752)
15. Ghanem KG, Moore RD, Rompalo AM, et al. Antiretroviral therapy is associated with reduced serologic failure rates for syphilis among HIVinfected patients. Clin Infect Dis 2008; 47:258-65. (Pubitemid 351920630)
16. Augenbraun MH, DeHovitz JA, Feldman J, et al. Biological falsepositivesyphilis test results for women infected with human immunodeficiency virus. Clin Infect Dis 1994; 19:1040-4. (Pubitemid 24380015)
17. Joyanes P, Borobio MV, Arquez JM, et al. The association of false positive rapid plasma reagin results and HIV infection. Sex Transm Dis 1998; 25:569-71. (Pubitemid 28553615)
18. Hernández-Aguado I, Bolumar F, Moreno R, et al. False-positive tests for syphilis associated with human immunodeficiency virus and hepatitis B virus infection among intravenous drug abusers. Valencian Study Group on HIV Epidemiology. Eur J Clin Microbiol Infect Dis 1998; 17:784-7. (Pubitemid 29219132)
19. Augenbraun M, French A, Glesby M, et al. Hepatitis C virus infection and biological false-positive syphilis tests. Sex Transm Infect 2010; 86:97-8.
20. Rusnak JM, Butzin C, McGlasson D, et al. False-positive rapid plasma reagin tests in human immunodeficiency virus infection and relationship to anti-cardiolipin antibody and serum immunoglobulin levels. J Infect Dis 1994; 169:1356-9. (Pubitemid 24164605)
21. Kaufman RE, Weiss S, Moore JD, et al. Biological false positive serological tests for syphilis among drug addicts. Br J Vener Dis 1974; 50:350-3.
22. Boak RA, Carpenter CM, Miller JN. Biologic false-positive reactions for syphilis among narcotic addicts. A report on the incidence of BFP reactions as measured by TPI test. JAMA 1961; 175:326.
23. Tuffanelli DL. Narcotic addiction with false-positive reaction for syphilis. Immunologic studies. Acta Derm Venereol 1968; 48:542-6.
24. Sonmez E, Ozerol IH, Senol M, et al. False-positive reaction between syphilis and hepatitis C infection. Isr J Med Sci 1997; 33:724-7. (Pubitemid 28014299)
25. Centers for Disease Control and Prevention. Primary and secondary syphilis-rates by sex and male-to-female rate ratios, United States, 1990-2011. Available at: http://www.cdc.gov/std/stats11/figures/38.htm. Accessed 10 March 2013.