Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase

Journal of Biological Chemistry

Volumn 288, Issue 37, 2013, Pages 26678-26687

  Du, Zhaoyang ^a,b   Tong, Xiaomei ^a   Ye, Xin ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE REGULATION; CELL-CYCLE PROGRESSION; CYCLIN-DEPENDENT KINASE; CYCLIND1; KINASE ACTIVITY; NOVEL FUNCTIONS;

CELLS; CYTOLOGY;

ENZYMES;

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; NUCLEAR DBF2 RELATED PROTEIN KINASE 1; NUCLEAR DBF2 RELATED PROTEIN KINASE 2; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

CELL CYCLE; CYCLINS; PROTEIN PHOSPHORYLATION; PROTEIN-PROTEIN INTERACTIONS; SERINE/THREONINE PROTEIN KINASE;

CELL CYCLE; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEK293 CELLS; HELA CELLS; HUMANS; MASS SPECTROMETRY; PHOSPHORYLATION; PLASMIDS; PROTEIN INTERACTION MAPPING; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE;

EID: 84884181723     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.466433     Document Type: Article

References (25)

1. Sherr, C. J., and Roberts, J. M. (1999) Cdk inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512
2. Matsuura, I., Denissova, N. G., Wang, G., He, D., Long, J., and Liu, F. (2004) Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430, 226-231
3. Anders, L., Ke, N., Hydbring, P., Choi, Y. J., Widlund, H. R., Chick, J. M., Zhai, H., Vidal, M., Gygi, S. P., Braun, P., and Sicinski, P. (2011) A systematic screen for Cdk4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell 20, 620-634
4. Chiba, S., Ikeda, M., Katsunuma, K., Ohashi, K., and Mizuno, K. (2009) MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes. Curr. Biol. 19, 675-681
5. Cornils, H., Kohler, R. S., Hergovich A., and Hemmings, B. A. (2011) Human NDR kinases control G1/S cell cycle transition by directly regulating p21 stability. Mol. Cell. Biol. 31, 1382-1395
6. Hergovich, A., Lamla, S., Nigg, E. A., and Hemmings, B. A. (2007) Centrosome- associated NDR kinase regulates centrosome duplication. Mol. Cell 25, 625-634
7. Suzuki, A., Ogura, T., and Esumi, H. (2006) NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. J. Biol. Chem. 281, 13915-13921
8. Vichalkovski, A., Gresko, E., Cornils, H., Hergovich, A., Schmitz, D., and Hemmings, B. A. (2008) NDR kinase is activated by RASSF1A/MST1 in response to FAS receptor stimulation and promotes apoptosis. Curr. Biol. 18, 1889-1895
9. Bichsel, S. J., Tamaskovic, R., Stegert, M. R., and Hemmings, B. A. (2004) Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. J. Biol. Chem. 279, 35228-35235
10. Tamaskovic, R., Bichsel, S. J., Rogniaux, H., Stegert, M. R., and Hemmings, B. A. (2003) Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase. J. Biol. Chem. 278, 6710-6718
11. Kohler, R. S., Schmitz, D., Cornils, H., Hemmings, B. A., and Hergovich, A. (2010) Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human Ndr kinases. Mol. Cell. Biol. 30, 4507-4520
12. Zhou, Y., Adolfs, Y., Pijnappel, W. W., Fuller, S. J., Van der Schors, R. C., Li, K. W., Sugden, P. H., Smit, A. B., Hergovich, A., and Pasterkamp, R. J. (2011) MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol. Cell. Biol. 31, 3603-3615
13. van den Heuvel, S., and Harlow, E. (1993) Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262, 2050-2054
14. Hinds, P. W., Dowdy, S. F., Eaton, E. N., Arnold, A., and Weinberg, R. A. (1994) Function of a human cyclin gene as an oncogene. Proc. Natl. Acad. Sci. U.S.A. 91, 709-713
15. Stegert, M. R., Tamaskovic, R., Bichsel, S. J., Hergovich, A., and Hemmings, B. A. (2004) Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. J. Biol. Chem. 279, 23806-23812
16. Deng, M., Li, F., Ballif, B. A., Li, S., Chen, X., Guo, L., and Ye, X. (2009) Identification and functional analysis of a novel cyclin E/Cdk2 substrate Ankrd17. J. Biol. Chem. 284, 7875-7888. Deleted in proof
17. Deleted in proof 18. Ratineau, C., Petry, M. W., Mutoh, H., and Leiter, A. B. (2002) Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. J. Biol. Chem. 277, 8847-8853
18. Inoue, K., and Sherr, C. J. (1998) Gene expression and cell cycle arrest mediated by transcription factor DMP1 is antagonized by D-type cyclins through a cyclin-dependent-kinase-independent mechanism. Mol. Cell. Biol. 18, 1590-1600
19. Hirai, H., and Sherr, C. J. (1996) Interaction of D-type cyclins with a novel Myb-like transcription factor, DMP1. Mol. Cell. Biol. 16, 6457-6467
20. Bienvenu, F., Gascan, H., and Coqueret, O. (2001) Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism. J. Biol. Chem. 276, 16840-16847
21. Zwijsen, R. M., Wientjens, E., Klompmaker, R., van der Sman, J., Bernards, R., and Michalides, R. J. (1997) Cdk-independent activation of estrogen receptor by cyclin D1. Cell 88, 405-415
22. Jirawatnotai, S., Hu, Y., Michowski, W., Elias, J. E., Becks, L., Bienvenu, F., Zagozdzon, A., Goswami, T., Wang, Y. E., Clark, A. B., Kunkel, T. A., van Harn, T., Xia, B., Correll, M., Quackenbush, J., Livingston, D. M., Gygi, S. P., and Sicinski, P. (2011) A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 474, 230-234
23. LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., and Harlow, E. (1997) New functional activities for the p21 family of Cdk inhibitors. Genes Dev. 11, 847-862
24. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816
25. Bornstein, G., Bloom, J., Sitry-Shevah, D., Nakayama, K., Pagano, M., and Hershko, A. (2003) Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J. Biol. Chem. 278, 25752-25757