Esmolol activates endogenous neurokinin activity inhibiting infarction-induced arrhythmias in rats: Novel mechanisms of anti-arrhythmia

Regulatory Peptides

Volumn 186, Issue , 2013, Pages 116-122

  Wang, Li Li ^a   Han, Yi ^a   Guo, Zheng ^a   Han, Shi Qi ^a   Liu, Tao ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

1 Adrenergic mechanism; Acute myocardial infarction; Esmolol; Neurokinin; Neurokinin 1 receptor; Ventricular arrhythmias

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; ESMOLOL; NEUROKININ; NEUROKININ 1 RECEPTOR; NORADRENALIN; SUBSTANCE P;

ACUTE HEART INFARCTION; ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DRUG ACTIVITY; DRUG MECHANISM; HEART ARRHYTHMIA; HEART MUSCLE ISCHEMIA; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; MALE; MORBIDITY; NONHUMAN; PRIORITY JOURNAL; RAT; UPREGULATION;

ACUTE MYOCARDIAL INFARCTION; D-SP; ESMOLOL; NE; NEUROKININ; NEUROKININ 1 RECEPTOR; NEUROKININ-1 RECEPTOR; NK1-R; NOREPINEPHRINE; SP; SUBSTANCE P; VENTRICULAR ARRHYTHMIAS; [D-ARG(1), D-PHE(5), D-TRP(7,9), LEU(11)]-SUBSTANCE P; Β1-ADRENERGIC MECHANISM; Β1-ADRENERGIC RECEPTOR; Β1-AR;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; CORONARY OCCLUSION; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; MALE; MYOCARDIAL INFARCTION; MYOCARDIUM; NEUROKININ-1 RECEPTOR ANTAGONISTS; NOREPINEPHRINE; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 84884179032     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2013.08.004     Document Type: Article

References (32)

1. Coronel R., Wilms-Schopman F.J.G., deGroot J.R. Origin of ischemia-induced phase 1b ventricular arrhythmias in pig hearts. JACC 2002, 39:166-176.
2. Schömig A. Catecholamines in myocardial ischemia: systemic and cardiac release. Circulation 1990, 82:II_13-II_22.
3. Schömig A., Haass M., Richardt G. Catecholamine release and arrhythmias in acute myocardial ischaemia. Eur Heart J 1991, 12(Suppl. F):38-47.
4. Tölg R., Kurz T., Ungerer M., Schreieck J., Görge B., Richardt G. Influence of alpha- and beta-adrenoceptor antagonists on ventricular fibrillation in ischemic rat hearts. Naunyn Schmiedebergs Arch Pharmacol 1997, 356:62-68.
5. Imani A., Faghihi M., Sadr S.S., Keshavarz M., Niaraki S.S. Noradrenaline reduces ischemia-induced arrhythmia in anesthetized rats: involvement of α1-adrenoceptors and mitochondrial KATP channels. J Cardiovasc Electrophysiol 2008, 19:309-315.
6. Végh Á., Parratt J.R. Noradrenaline, infused locally, reduces arrhythmia severity during coronary artery occlusion in anaesthetised dogs. Cardiovasc Res 2002, 55:53-63.
7. Hua F., Richetts B.A., Reifsteck A., Ardell J.L., Williams C.A. Myocardial ischemia induces the release of substance P from cardiac afferent neurons in rat thoracic spinal cord. Am J Physiol Heart Circ Physiol 2004, 286:H1654-H1664.
8. Guo Z., Niu Y.L., Zhang J.W., Yao T.P. Coronary artery occlusion alters expression of substance P and its mRNA in spinal dorsal horn in rats. Neuroscience 2007, 145:669-675.
9. Milner P., Ralevic V., Hopwood A.M., Feher E., Lincoln J., Kirkpatrick K.A., Burn stock G. Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia. Experientia 1989, 45:121-125.
10. Zhang J.W., Guo Z. Changes in substance P in myocardium and dorsal root ganglion following coronary artery occlusion in rats. Chin J Crit Care Med 2006, 18:201-205. [in Chinese].
11. Chiao H., Caldwell R.W. The role of substance P in myocardial dysfunction during ischemia and reperfusion. Naunyn Schmiedebergs Arch Pharmacol 1996, 353:400-407.
12. Wang L.L., Guo Z., Han Y., Wang P.F., Zhang R.L., Zhao Y.L., Zhao F.P., Zhao X.Y. Implication of substance P in myocardial contractile function during ischemia in rats. Regul Pept 2011, 167:185-191.
13. Zhou X., Vance F.L., Sims A.L., Sreenan C.M., Ideker R.E. Prevention of high incidence of neurally mediated ventricular arrhythmias by afferent nerve stimulation in dogs. Circulation 2000, 101:819-824.
14. http://grants.nih.gov/grants/olaw/olaw.htm.
15. Walker M.J., Curtis M.J., Hearse D.J., Campbell R.W., Janse M.J., Yellon D.M., Cobbe S.M., Coker S.J., Harness J.B., Harron D.W. The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion. Cardiovasc Res 1988, 22:447-455.
16. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
17. Brown M.J., Morice A.H. Clinical pharmacology of vasodilator peptides. J Cardiovasc Pharmacol 1987, 10:582-590.
18. Brain S.D., Grant A.D. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev 2004, 84:903-934.
19. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 1988, 45:739-768.
20. Kawasaki H., Nuki C., Saito A., Takasaki K. Adrenergic modulation of calcitonin gene-related peptide (CGRP)-containing nerve-mediated vasodilation in the rat mesenteric resistance vessel. Brain Res 1990, 506:287-290.
21. Fiskerstrand C., Quinn J.P. The molecular biology of preprotachykinin-A gene expression. Neuropeptides 1996, 30:602-610.
22. Head R.J., Cassis L.A., Robinson R.L., Westfall D.P., Stizel R.E. Altered catecholamine contents in vascular and nonvascular tissues in genetically hypertensive rats. Blood Vessels 1985, 22:196-204.
23. Zettler C., Rush R.A. Elevated concentrations of nerve growth factor in heart and mesenteric arteries of spontaneously hypertensive rats. Brain Res 1993, 614:15-20.
24. Kohlmann O., Cesaretti M.L., Ginoza M., Tavares A., Zanella M.T., Ribeiro A.B., Ramos O.L., Leeman S.E., Gavras I., Gavras H. Role of substance P in blood pressure regulation in salt-dependent experimental hypertension. Hypertension 1997, 29:506-509.
25. Supowit S.C., Ethridge R.T., Zhao H., Katki K.A., DiPette D.J. Calcitonin gene-related peptide and substance P contribute to reduced blood pressure in sympathectomized rats. Am J Physiol Heart Circ Physiol 2005, 289:H1169-H1175.
26. Bers D.M. Cardiac excitation-contraction coupling. Nature 2002, 415:198-205.
27. Petersen C.L., Nielsen J.R., Petersen B.L., Kjaer A. Catecholaminergic activation in acute myocardial infarction: time course and relation to left ventricular performance. Cardiology 2003, 100:23-28.
28. Zhang R.L., Guo Z., Wang L.L., Wu J. Degeneration of capsaicin sensitive sensory nerves enhances myocardial injury in acute myocardial infarction in rats. Int J Cardiol 2012, 160:41-47.
29. Galligan J.J., Jiang M.M., Shen K.Z., Surprenant A. Substance P mediates neurogenic vasodilatation in extrinsically denervated guinea-pig submucosal arterioles. J Physiol 1990, 420:267-280.
30. Huang M.H., Wang H.Q., Roeske W.R., Birnbaum Y., Wu Y.W., Yang N.P., Lin Y., Ye Y.M., McAdoo D.J., Hughes M.G., Lick S.D., Boor P.J., Lui C.Y., Uretsky B.F. Mediating δ-opioid-initiated heart protection via the β2-adrenergic receptor: role of the intrinsic cardiac adrenergic cell. Am J Physiol Heart Circ Physiol 2007, 293:H376-H384.
31. Huang M.H., Nguyen V., Wu Y.W., Rastogi S., Lui C.Y., Birnbaum Y., Wang H.Q., Ware D.L., Chauhan M., Garg N., Poh K.K., Ye L., Omar A.R., Tan H.C., Uretsky B.F., Fujise K. Reducing ischaemia/reperfusion injury through δ-opioid-regulated intrinsic cardiac adrenergic cells: adrenopeptidergic co-signalling. Cardiovasc Res 2009, 84:452-460.
32. Paletta M.J., Abraham S., Beatch G.N., Walker M.J. Mechanisms underlying the antiarrhythmic properties of beta-adrenoceptor blockade against ischaemia-induced arrhythmias in acutely prepared rats. Br J Pharmacol 1989, 98:87-94.