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Volumn 4, Issue FEB, 2013, Pages

Linagliptin: A thorough characterization beyond its clinical efficacy

Author keywords

Anti diabetic drugs; Diabetes mellitus; DPP 4 inhibitors; Glp 1; Incretin

Indexed keywords

ALOGLIPTIN; CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CREATININE; DIGOXIN; ETHINYLESTRADIOL PLUS LEVONORGESTREL; GLIBENCLAMIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; INCRETIN; INSULIN; LEPTIN; LINAGLIPTIN; LINAGLIPTIN PLUS METFORMIN; LIVER ENZYME; PIOGLITAZONE; PLACEBO; SAXAGLIPTIN; SIMVASTATIN; SITAGLIPTIN; STROMAL CELL DERIVED FACTOR 1ALPHA; SULFONYLUREA; VILDAGLIPTIN; VOGLIBOSE; WARFARIN;

EID: 84884178268     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2013.00016     Document Type: Review
Times cited : (30)

References (51)
  • 1
    • 84869238002 scopus 로고    scopus 로고
    • DPP-4 inhibition on top of angiotensin receptor blockade offers a new therapeutic approach for diabetic nephropathy
    • Alter, M. L., Ott, I. M., von Websky, K., Tsuprykov, O., Sharkovska, Y., Krause-Relle, K., et al. (2012). DPP-4 inhibition on top of angiotensin receptor blockade offers a new therapeutic approach for diabetic nephropathy. Kidney Blood Press. Res. 36, 119-130.
    • (2012) Kidney Blood Press. Res. , vol.36 , pp. 119-130
    • Alter, M.L.1    Ott, I.M.2    von Websky, K.3    Tsuprykov, O.4    Sharkovska, Y.5    Krause-Relle, K.6
  • 2
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio, L. L., and Drucker, D. J. (2007). Biology of incretins: GLP-1 and GIP. Gastroenterology 132, 2131-2157.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 3
    • 84873263426 scopus 로고    scopus 로고
    • Linagliptin monotherapy in type 2 diabetes patients for whom metformin is inappropriate: an 18-week randomized, double-blind, placebo-controlled Phase III trial with a 34-week active-controlled extension
    • Barnett, A. H., Patel, S., Harper, R., Toorawa, R., Thiemann, S., von Eynatten, M., et al. (2012). Linagliptin monotherapy in type 2 diabetes patients for whom metformin is inappropriate: an 18-week randomized, double-blind, placebo-controlled Phase III trial with a 34-week active-controlled extension. Diabetes Obes. Metab. 14, 1145-1154.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 1145-1154
    • Barnett, A.H.1    Patel, S.2    Harper, R.3    Toorawa, R.4    Thiemann, S.5    von Eynatten, M.6
  • 4
    • 84866540801 scopus 로고    scopus 로고
    • Effects of combining linagliptin treatment with bi-38335, a novel sglt2 inhibitor, on pancreatic islet function and inflammation in db/db mice
    • Chen, L., Klein, T., and Leung, P. S. (2012). Effects of combining linagliptin treatment with bi-38335, a novel sglt2 inhibitor, on pancreatic islet function and inflammation in db/db mice. Curr. Mol. Med. 12, 995-1004.
    • (2012) Curr. Mol. Med. , vol.12 , pp. 995-1004
    • Chen, L.1    Klein, T.2    Leung, P.S.3
  • 5
    • 84884172473 scopus 로고    scopus 로고
    • The DPP-4 inhibitor linagliptin counteracts stroke in the normal and diabetic mouse brain: a comparison with glimepiride
    • PMID:23209191. [Epub ahead of print].
    • Darsalia, V., Ortsäter, H., Olverling, A., Darlöf, E., Wolbert, P., Nyström, T., et al. (2012). The DPP-4 inhibitor linagliptin counteracts stroke in the normal and diabetic mouse brain: a comparison with glimepiride. Diabetes. PMID:23209191. [Epub ahead of print].
    • (2012) Diabetes
    • Darsalia, V.1    Ortsäter, H.2    Olverling, A.3    Darlöf, E.4    Wolbert, P.5    Nyström, T.6
  • 6
    • 78649686908 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in the treatment of type-2 diabetes: a comparative review
    • Deacon, C. F. (2011). Dipeptidyl peptidase-4 inhibitors in the treatment of type-2 diabetes: a comparative review. Diabetes Obes. Metab. 13, 7-18.
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 7-18
    • Deacon, C.F.1
  • 7
    • 81255150186 scopus 로고    scopus 로고
    • Linagliptin for the treatment of type 2 diabetes
    • Del Prato, S. (2011). Linagliptin for the treatment of type 2 diabetes. Expert Opin. Pharmacother. 12, 2759-2762.
    • (2011) Expert Opin. Pharmacother. , vol.12 , pp. 2759-2762
    • Del Prato, S.1
  • 8
    • 78851472527 scopus 로고    scopus 로고
    • Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial
    • Del Prato, S., Barnett, A. H., Huisman, H., Neubacher, D., Woerle, H. J., and Dugi, K. A. (2011). Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial. Diabetes Obes. Metab. 13, 258-267.
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 258-267
    • Del Prato, S.1    Barnett, A.H.2    Huisman, H.3    Neubacher, D.4    Woerle, H.J.5    Dugi, K.A.6
  • 9
    • 37349073397 scopus 로고    scopus 로고
    • 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-yl methyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes
    • Eckhardt, M., Langkopf, E., Mark, M., Tadayyon, M., Thomas, L., Nar, H., et al. (2007). 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-yl methyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes. J. Med. Chem. 50, 6450-6453.
    • (2007) J. Med. Chem. , vol.50 , pp. 6450-6453
    • Eckhardt, M.1    Langkopf, E.2    Mark, M.3    Tadayyon, M.4    Thomas, L.5    Nar, H.6
  • 10
    • 79953044464 scopus 로고    scopus 로고
    • Linagliptin (BI 1356), a potent and selective DPP-4 inhibitor, is safe and efficacious in combination with metformin in patients with inadequately controlled Type 2 diabetes
    • Forst, T., Uhlig-Laske, B., Ring, A., Graefe-Mody, U., Friedrich, C., Herbach, K., et al. (2010). Linagliptin (BI 1356), a potent and selective DPP-4 inhibitor, is safe and efficacious in combination with metformin in patients with inadequately controlled Type 2 diabetes. Diabet. Med. 27, 1409-1419.
    • (2010) Diabet. Med. , vol.27 , pp. 1409-1419
    • Forst, T.1    Uhlig-Laske, B.2    Ring, A.3    Graefe-Mody, U.4    Friedrich, C.5    Herbach, K.6
  • 11
    • 79955022470 scopus 로고    scopus 로고
    • The oral DPP-4 inhibitor linagliptin significantly lowers HbA1c after 4 weeks of treatment in patients with type 2 diabetes mellitus
    • Forst, T., Uhlig-Laske, B., Ring, A., Ritzhaupt, A., Graefe-Mody, U., and Dugi, K. A. (2011). The oral DPP-4 inhibitor linagliptin significantly lowers HbA1c after 4 weeks of treatment in patients with type 2 diabetes mellitus. Diabetes Obes. Metab. 13, 542-550.
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 542-550
    • Forst, T.1    Uhlig-Laske, B.2    Ring, A.3    Ritzhaupt, A.4    Graefe-Mody, U.5    Dugi, K.A.6
  • 12
    • 80051536297 scopus 로고    scopus 로고
    • Effect of multiple oral doses of linagliptin on the steady state pharmacokinetics of a combination oral contraceptive in healthy female adults: an open label, two-period, fixed-sequence, multiple-dose study
    • Friedrich, C., Port, A., Ring, A., Graefe-Mody, E. U., Giessmann, T., Iovino, M., et al. (2011a). Effect of multiple oral doses of linagliptin on the steady state pharmacokinetics of a combination oral contraceptive in healthy female adults: an open label, two-period, fixed-sequence, multiple-dose study. Clin. Drug Invest. 31, 643-653.
    • (2011) Clin. Drug Invest. , vol.31 , pp. 643-653
    • Friedrich, C.1    Port, A.2    Ring, A.3    Graefe-Mody, E.U.4    Giessmann, T.5    Iovino, M.6
  • 13
    • 79954427139 scopus 로고    scopus 로고
    • Evaluation of the pharmacokinetic interactions after multiple oral doses of linagliptin and digoxin in healthy volunteers
    • Friedrich, C., Ring, A., Brand, T., Sennewald, R., Graefe-Mody, E. U., and Woerle, H. J. (2011b). Evaluation of the pharmacokinetic interactions after multiple oral doses of linagliptin and digoxin in healthy volunteers. Eur. J. Drug Metab. Pharmacokinet. 36, 17-24.
    • (2011) Eur. J. Drug Metab. Pharmacokinet. , vol.36 , pp. 17-24
    • Friedrich, C.1    Ring, A.2    Brand, T.3    Sennewald, R.4    Graefe-Mody, E.U.5    Woerle, H.J.6
  • 14
    • 70349733673 scopus 로고    scopus 로고
    • Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats
    • Fuchs, H., Binder, R., and Greischel, A. (2009a). Tissue distribution of the novel DPP-4 inhibitor BI 1356 is dominated by saturable binding to its target in rats. Biopharm. Drug Dispos. 30, 229-240.
    • (2009) Biopharm. Drug Dispos. , vol.30 , pp. 229-240
    • Fuchs, H.1    Binder, R.2    Greischel, A.3
  • 15
    • 58149247983 scopus 로고    scopus 로고
    • Concentration dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans
    • Fuchs, H., Tillement, J.-P., Urien, S., Greischel, A., and Roth, W. (2009b). Concentration dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans. J. Pharm. Pharmacol. 61, 55-62.
    • (2009) J. Pharm. Pharmacol. , vol.61 , pp. 55-62
    • Fuchs, H.1    Tillement, J.-P.2    Urien, S.3    Greischel, A.4    Roth, W.5
  • 16
    • 84857917241 scopus 로고    scopus 로고
    • Excretion of the dipeptidyl peptidase-4 inhibitor linagliptin in rats is primarily by biliary excretion and P-gp-mediated efflux
    • Fuchs, H., Runge, F., and Held, H. D. (2012). Excretion of the dipeptidyl peptidase-4 inhibitor linagliptin in rats is primarily by biliary excretion and P-gp-mediated efflux. Eur. J. Pharm. Sci. 45, 533-538.
    • (2012) Eur. J. Pharm. Sci. , vol.45 , pp. 533-538
    • Fuchs, H.1    Runge, F.2    Held, H.D.3
  • 17
    • 34250346390 scopus 로고    scopus 로고
    • Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors
    • Gao, Y. D., Feng, D., Sheridan, R. P., Scapin, G., Patel, S. B., Wu, J. K., et al. (2007). Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors. Bioorg. Med. Chem. Lett. 17, 3877-3879.
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 3877-3879
    • Gao, Y.D.1    Feng, D.2    Sheridan, R.P.3    Scapin, G.4    Patel, S.B.5    Wu, J.K.6
  • 18
    • 79953174825 scopus 로고    scopus 로고
    • Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study
    • Gomis, R., Espadero, R. M., Jones, R., Woerle, H. J., and Dugi, K. A. (2011). Efficacy and safety of initial combination therapy with linagliptin and pioglitazone in patients with inadequately controlled type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes. Metab. 13, 653-661.
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 653-661
    • Gomis, R.1    Espadero, R.M.2    Jones, R.3    Woerle, H.J.4    Dugi, K.A.5
  • 19
    • 79955980589 scopus 로고    scopus 로고
    • Effect of linagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers
    • Graefe-Mody, E. U., Brand, T., Ring, A., Withopf, B., Stangier, J., Iovino, M., et al. (2011a). Effect of linagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. Int. J. Clin. Pharmacol. Ther. 49, 300-310.
    • (2011) Int. J. Clin. Pharmacol. Ther. , vol.49 , pp. 300-310
    • Graefe-Mody, E.U.1    Brand, T.2    Ring, A.3    Withopf, B.4    Stangier, J.5    Iovino, M.6
  • 20
    • 80052530183 scopus 로고    scopus 로고
    • Effect of renal impairment on the pharmacokinetics of the dipeptidyl peptidase-4 inhibitor linagliptin
    • Graefe-Mody, U., Friedrich, C., Port, A., Ring, A., Retlich, S., Heise, T., et al. (2011b). Effect of renal impairment on the pharmacokinetics of the dipeptidyl peptidase-4 inhibitor linagliptin. Diabetes Obes. Metab. 13, 939-946.
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 939-946
    • Graefe-Mody, U.1    Friedrich, C.2    Port, A.3    Ring, A.4    Retlich, S.5    Heise, T.6
  • 21
    • 80051653327 scopus 로고    scopus 로고
    • A randomized open-label crossover study evaluating the effect of food on the relative bioavailability of linagliptin in healthy subjects
    • Graefe-Mody, U., Giessmann, T., Ring, A., Iovino, M., and Woerle, H. J. (2011c). A randomized open-label crossover study evaluating the effect of food on the relative bioavailability of linagliptin in healthy subjects. Clin. Ther. 33, 1096-1103.
    • (2011) Clin. Ther. , vol.33 , pp. 1096-1103
    • Graefe-Mody, U.1    Giessmann, T.2    Ring, A.3    Iovino, M.4    Woerle, H.J.5
  • 22
    • 79955712959 scopus 로고    scopus 로고
    • Assessment of the pharmacokinetic interaction between the novel DPP-4 inhibitor linagliptin and a sulfonylurea, glyburide, in healthy subjects
    • Graefe-Mody, U., Rose, P., Ring, A., Zander, K., Iovino, M., and Woerle, H. J. (2011d). Assessment of the pharmacokinetic interaction between the novel DPP-4 inhibitor linagliptin and a sulfonylurea, glyburide, in healthy subjects. Drug Metab. Pharmacokinet. 26, 123-129.
    • (2011) Drug Metab. Pharmacokinet. , vol.26 , pp. 123-129
    • Graefe-Mody, U.1    Rose, P.2    Ring, A.3    Zander, K.4    Iovino, M.5    Woerle, H.J.6
  • 24
    • 77957665412 scopus 로고    scopus 로고
    • Evaluation of the pharmacokinetic interaction between the dipeptidyl peptidase-4 inhibitor linagliptin and pioglitazone in healthy volunteers
    • Graefe-Mody, E. U., Jungnik, A., Ring, A., Woerle, H. J., and Dugi, K. A. (2010b). Evaluation of the pharmacokinetic interaction between the dipeptidyl peptidase-4 inhibitor linagliptin and pioglitazone in healthy volunteers. Int. J. Clin. Pharmacol. Ther. 48, 652-661.
    • (2010) Int. J. Clin. Pharmacol. Ther. , vol.48 , pp. 652-661
    • Graefe-Mody, E.U.1    Jungnik, A.2    Ring, A.3    Woerle, H.J.4    Dugi, K.A.5
  • 25
    • 67650799130 scopus 로고    scopus 로고
    • Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects
    • Graefe-Mody, E. U., Padula, S., Ring, A., Withopf, B., and Dugi, K. A. (2009). Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects. Curr. Med. Res. Opin. 25, 1963-1972.
    • (2009) Curr. Med. Res. Opin. , vol.25 , pp. 1963-1972
    • Graefe-Mody, E.U.1    Padula, S.2    Ring, A.3    Withopf, B.4    Dugi, K.A.5
  • 27
    • 77956007404 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor linagliptin exhibits time- and dose-dependent localization in kidney, liver, and intestine after intravenous dosing: results from high resolution autoradiography in rats
    • Greischel, A., Binder, R., and Baierl, J. (2010). The dipeptidyl peptidase-4 inhibitor linagliptin exhibits time- and dose-dependent localization in kidney, liver, and intestine after intravenous dosing: results from high resolution autoradiography in rats. Drug Metab. Dispos. 38, 1443-1448.
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 1443-1448
    • Greischel, A.1    Binder, R.2    Baierl, J.3
  • 28
    • 84862813117 scopus 로고    scopus 로고
    • Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomised, double-blind, placebo-controlled study
    • Haak, T., Meinicke, T., Jones, R., Weber, S., von Eynatten, M., and Woerle, H. J. (2012). Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomised, double-blind, placebo-controlled study. Diabetes Obes. Metab. 14, 565-574.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 565-574
    • Haak, T.1    Meinicke, T.2    Jones, R.3    Weber, S.4    von Eynatten, M.5    Woerle, H.J.6
  • 29
    • 67649998759 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients
    • Heise, T., Graefe-Mody, E. U., Hüttner, S., Ring, A., Trommeshauser, D., and Dugi, K. A. (2009). Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients. Diabetes Obes. Metab. 11, 786-794.
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 786-794
    • Heise, T.1    Graefe-Mody, E.U.2    Hüttner, S.3    Ring, A.4    Trommeshauser, D.5    Dugi, K.A.6
  • 30
    • 84865576863 scopus 로고    scopus 로고
    • Renal and cardiac effects of DPP-4 inhibitors - from preclinical development to clinical research
    • Hocher, B., Reichetzeder, C., and Alter, M. (2012a). Renal and cardiac effects of DPP-4 inhibitors - from preclinical development to clinical research. Kidney Blood Press. Res. 36, 65-84
    • (2012) Kidney Blood Press. Res. , vol.36 , pp. 65-84
    • Hocher, B.1    Reichetzeder, C.2    Alter, M.3
  • 31
    • 84866069419 scopus 로고    scopus 로고
    • The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats
    • PMID:22217485. [Epub ahead of print].
    • Hocher, B, Sharkovska, Y., Mark, M., Klein, T., and Pfab, T. (2012b). The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats. Int. J. Cardiol. PMID:22217485. [Epub ahead of print].
    • (2012) Int. J. Cardiol.
    • Hocher, B.1    Sharkovska, Y.2    Mark, M.3    Klein, T.4    Pfab, T.5
  • 32
    • 51849103389 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase 4, in healthy male volunteers
    • Hüttner, S., Graefe-Mody, E. U., Withopf, B., Ring, A., and Dugi, K. A. (2008). Safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of BI 1356, an inhibitor of dipeptidyl peptidase 4, in healthy male volunteers. J. Clin. Pharmacol. 48, 1171-1178.
    • (2008) J. Clin. Pharmacol. , vol.48 , pp. 1171-1178
    • Hüttner, S.1    Graefe-Mody, E.U.2    Withopf, B.3    Ring, A.4    Dugi, K.A.5
  • 33
    • 84871551884 scopus 로고    scopus 로고
    • Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods
    • Ishiguro, N., Shimizu, H., Kishimoto, W., Ebner, T., and Schaefer, O. (2013). Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods. Drug Metab. Dispos. 41, 149-158.
    • (2013) Drug Metab. Dispos. , vol.41 , pp. 149-158
    • Ishiguro, N.1    Shimizu, H.2    Kishimoto, W.3    Ebner, T.4    Schaefer, O.5
  • 34
    • 84866303239 scopus 로고    scopus 로고
    • The DPP-4 inhibitor linagliptin delays the onset of diabetes and preserves β cell mass in the non-obese diabetic NOD mice
    • Jelsing, J., Vrang, N., Mark, M., and Klein, T. (2012). The DPP-4 inhibitor linagliptin delays the onset of diabetes and preserves β cell mass in the non-obese diabetic NOD mice. J. Endocrinol. 214, 381-387.
    • (2012) J. Endocrinol. , vol.214 , pp. 381-387
    • Jelsing, J.1    Vrang, N.2    Mark, M.3    Klein, T.4
  • 35
    • 84855481995 scopus 로고    scopus 로고
    • Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a Phase 3 programme
    • Johansen, O. E., Neubacher, D., von Eynatten, M., Patel, S., and Woerle, H. J. (2012). Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: a pre-specified, prospective, and adjudicated meta-analysis of a Phase 3 programme. Cardiovasc. Diabetol. 11, 3-12.
    • (2012) Cardiovasc. Diabetol. , vol.11 , pp. 3-12
    • Johansen, O.E.1    Neubacher, D.2    von Eynatten, M.3    Patel, S.4    Woerle, H.J.5
  • 36
    • 84858003503 scopus 로고    scopus 로고
    • Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study
    • Kawamori, R., Inagaki, N., Araki, E., Watada, H., Hayashi, N., Horie, Y., et al. (2012). Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study. Diabetes Obes. Metab. 14, 348-357.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 348-357
    • Kawamori, R.1    Inagaki, N.2    Araki, E.3    Watada, H.4    Hayashi, N.5    Horie, Y.6
  • 37
    • 84862692484 scopus 로고    scopus 로고
    • Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity
    • doi:10.1371/journal.pone.0038744
    • Kern, M., Klöting, N., Niessen, H. G., Thomas, L., Stiller, D., Mark, M., et al. (2012). Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity. PLoS ONE 7:e38744. doi:10.1371/journal.pone.0038744
    • (2012) PLoS ONE , vol.7
    • Kern, M.1    Klöting, N.2    Niessen, H.G.3    Thomas, L.4    Stiller, D.5    Mark, M.6
  • 38
    • 84867139120 scopus 로고    scopus 로고
    • Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine
    • Klein, T., Grempler, R., Mayoux, E., Niessen, H., Cheetham, S., Stiller, D., et al. (2012). Evaluation of body fat composition after linagliptin treatment in a rat model of diet-induced obesity: a magnetic resonance spectroscopy study in comparison with sibutramine. Diabetes Obes. Metab. v14, 1050-1053.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 1050-1053
    • Klein, T.1    Grempler, R.2    Mayoux, E.3    Niessen, H.4    Cheetham, S.5    Stiller, D.6
  • 39
    • 84866644965 scopus 로고    scopus 로고
    • Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition
    • Kröller-Schön, S., Knorr, M., Hausding, M., Oelze, M., Schuff, A., Schell, R., et al. (2012). Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition. Cardiovasc. Res. 96, 140-149.
    • (2012) Cardiovasc. Res. , vol.96 , pp. 140-149
    • Kröller-Schön, S.1    Knorr, M.2    Hausding, M.3    Oelze, M.4    Schuff, A.5    Schell, R.6
  • 40
    • 53149100519 scopus 로고    scopus 로고
    • Seprase: an overview of an important matrix serine protease
    • O'Brien, P., and O'Connor, B. F. (2008). Seprase: an overview of an important matrix serine protease. Biochim. Biophys. Acta 1784, 1130-1145.
    • (2008) Biochim. Biophys. Acta , vol.1784 , pp. 1130-1145
    • O'Brien, P.1    O'Connor, B.F.2
  • 41
    • 80053072352 scopus 로고    scopus 로고
    • Efficacy and safety of linagliptin in persons with Type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study
    • Owens, D. R., Swallow, R., Dugi, K. A., and Woerle, H.-J. (2011). Efficacy and safety of linagliptin in persons with Type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study. Diabet. Med. 28, 1352-1361.
    • (2011) Diabet. Med. , vol.28 , pp. 1352-1361
    • Owens, D.R.1    Swallow, R.2    Dugi, K.A.3    Woerle, H.-J.4
  • 42
    • 70549090031 scopus 로고    scopus 로고
    • Binding to dipeptidyl peptidase-4 determines the disposition of linagliptin (BI 1356) - investigations in DPP-4 deficient and wildtype rats
    • Retlich, S., Withopf, B., Greischel, A., Staab, A., Jaehde, U., and Fuchs, H. (2009). Binding to dipeptidyl peptidase-4 determines the disposition of linagliptin (BI 1356) - investigations in DPP-4 deficient and wildtype rats. Biopharm. Drug Dispos. 30, 422-436.
    • (2009) Biopharm. Drug Dispos. , vol.30 , pp. 422-436
    • Retlich, S.1    Withopf, B.2    Greischel, A.3    Staab, A.4    Jaehde, U.5    Fuchs, H.6
  • 43
    • 79953217579 scopus 로고    scopus 로고
    • The DPP-4 inhibitor linagliptin does not prolong the QT interval at therapeutic and subtherapeutic doses
    • Ring, A., Port, A., Graefe-Mody, E. U., Revollo, I., Iovino, M., and Dugi, K. A. (2011). The DPP-4 inhibitor linagliptin does not prolong the QT interval at therapeutic and subtherapeutic doses. Br. J. Clin. Pharmacol. 72, 39-50.
    • (2011) Br. J. Clin. Pharmacol. , vol.72 , pp. 39-50
    • Ring, A.1    Port, A.2    Graefe-Mody, E.U.3    Revollo, I.4    Iovino, M.5    Dugi, K.A.6
  • 44
    • 84867304934 scopus 로고    scopus 로고
    • Recent advances in incretin-based therapies
    • Russell-Jones, D., and Gough, S. (2012). Recent advances in incretin-based therapies. Clin. Endocrinol. (Oxf.) 77, 489-499.
    • (2012) Clin. Endocrinol. (Oxf.) , vol.77 , pp. 489-499
    • Russell-Jones, D.1    Gough, S.2
  • 45
    • 84859438114 scopus 로고    scopus 로고
    • Safety and tolerability of linagliptin: a pooled analysis of data from randomized controlled trials in 3572 patients with type 2 diabetes mellitus
    • Schernthaner, G., Barnett, A. H., Emser, A., Patel, S., Troost, J., Woerle, H. J., et al. (2012). Safety and tolerability of linagliptin: a pooled analysis of data from randomized controlled trials in 3572 patients with type 2 diabetes mellitus. Diabetes Obes. Metab. 14, 470-478.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 470-478
    • Schernthaner, G.1    Barnett, A.H.2    Emser, A.3    Patel, S.4    Troost, J.5    Woerle, H.J.6
  • 46
    • 84862495415 scopus 로고    scopus 로고
    • The Dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice
    • Schürmann, C., Linke, A., Engelmann-Pilger, K., Steinmetz, C., Frank, C., Mark, M., et al. (2012). The Dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice. J. Pharmacol. Exp. Ther. 342, 71-80.
    • (2012) J. Pharmacol. Exp. Ther. , vol.342 , pp. 71-80
    • Schürmann, C.1    Linke, A.2    Engelmann-Pilger, K.3    Steinmetz, C.4    Frank, C.5    Mark, M.6
  • 48
    • 78649691630 scopus 로고    scopus 로고
    • Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study
    • Taskinen, M. R., Rosenstock, J., Tamminen, I., Kubiak, R., Patel, S., Dugi, K. A., et al. (2011). Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes. Metab. 13, 65-74.
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 65-74
    • Taskinen, M.R.1    Rosenstock, J.2    Tamminen, I.3    Kubiak, R.4    Patel, S.5    Dugi, K.A.6
  • 49
    • 41149118550 scopus 로고    scopus 로고
    • (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-yl methyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors
    • Thomas, L., Eckhardt, M., Langkopf, E., Tadayyon, M., Himmelsbach, F., and Mark, M. (2008). (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-yl methyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J. Pharmacol. Exp. Ther. 325, 175-182.
    • (2008) J. Pharmacol. Exp. Ther. , vol.325 , pp. 175-182
    • Thomas, L.1    Eckhardt, M.2    Langkopf, E.3    Tadayyon, M.4    Himmelsbach, F.5    Mark, M.6
  • 50
    • 59649105751 scopus 로고    scopus 로고
    • Chronic treatment with the dipeptidyl peptidase-4 inhibitor BI 1356 [(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-yl methyl)-3,7-dihydro-purine-2,6-dione] increases basal glucagon-like peptide-1 and improves glycemic control in diabetic rodent models
    • Thomas, L., Tadayyon, M., and Mark, M. (2009). Chronic treatment with the dipeptidyl peptidase-4 inhibitor BI 1356 [(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-yl methyl)-3,7-dihydro-purine-2,6-dione] increases basal glucagon-like peptide-1 and improves glycemic control in diabetic rodent models. J. Pharmacol. Exp. Ther. 328, 556-563.
    • (2009) J. Pharmacol. Exp. Ther. , vol.328 , pp. 556-563
    • Thomas, L.1    Tadayyon, M.2    Mark, M.3
  • 51
    • 84866069401 scopus 로고    scopus 로고
    • Effects of the DPP-4 inhibitor, linagliptin, in diet-induced obese rats: a comparison in naive and exenatide-treated animals
    • Vickers, S. P., Cheetham, S. C., Birmingham, G. D., Rowley, H. L., Headland, K. R., Dickinson, K., et al. (2012). Effects of the DPP-4 inhibitor, linagliptin, in diet-induced obese rats: a comparison in naive and exenatide-treated animals. Clin. Lab. 58, 787-799.
    • (2012) Clin. Lab. , vol.58 , pp. 787-799
    • Vickers, S.P.1    Cheetham, S.C.2    Birmingham, G.D.3    Rowley, H.L.4    Headland, K.R.5    Dickinson, K.6


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