Metabolism studies of ifenprodil, a potent GluN2B receptor antagonist

Journal of Pharmaceutical and Biomedical Analysis

Volumn 88, Issue , 2014, Pages 96-105

  Falck, Evamaria ^a   Begrow, Frank ^a   Verspohl, Eugen ^a   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

GluN2B receptor antagonists; Ifenprodil; In vitro and in vivo metabolism; LC MS; NMDA receptor

Indexed keywords

GLUCURONIDE; IFENPRODIL TARTRATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEALKYLATION; DRUG METABOLISM; DRUG TRANSFORMATION; FEMALE; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

ADENOSINE-3′-PHOSPHATE-5′-PHOSPHOSULFATE LITHIUM SALT HYDRATE; BOVINE SERUM ALBUMIN; BSA; CATECHOL-O-METHYL TRANSFERASE; CENTRAL NERVOUS SYSTEM; CNS; COMT; EIC; EXTRACTED ION CURRENT; GLUN2B RECEPTOR ANTAGONISTS; IFENPRODIL; IN VITRO AND IN VIVO METABOLISM; LC-MS; N-METHYL-D-ASPARTATE; NADPH; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NMDA; NMDA RECEPTOR; PAPS; S-(5′-ADENOSYL)-L-METHIONINE IODIDE; SAM; TIC; TOTAL ION CURRENT; UDPGA; URIDINE 5′-DIPHOSPHOGLUCURONIC ACID TRISODIUM SALT;

ANIMALS; BINDING SITES; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CATTLE; CHROMATOGRAPHY, LIQUID; FEMALE; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; PHENOL; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SERUM ALBUMIN;

EID: 84884172327     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.08.014     Document Type: Article

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