Desensitization by Progressive Up-Titration Prevents First-Dose Effects on the Heart: Guinea Pig Study with Ponesimod, a Selective S1P1 Receptor Modulator

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Rey, Markus ^a   Hess, Patrick ^a   Clozel, Martine ^a   Delahaye, Stéphane ^a   Gatfield, John ^a   Nayler, Oliver ^a   Steiner, Beat ^a  

^a ACTELION PHARMACEUTICALS LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PONESIMOD; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR EFFECT; COMPLETE HEART BLOCK; CONTROLLED STUDY; DESENSITIZATION; DOSAGE SCHEDULE COMPARISON; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG DOSE TITRATION; DRUG EFFECT; DRUG HALF LIFE; ELECTROCARDIOGRAPHY; FIRST DEGREE ATRIOVENTRICULAR BLOCK; GUINEA PIG; HEART RATE; LYMPHOCYTE COUNT; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; SECOND DEGREE ATRIOVENTRICULAR BLOCK; TELEMETRY;

ADMINISTRATION, ORAL; ANIMALS; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR NODE; BLOOD PRESSURE; DRUG TOLERANCE; ELECTROCARDIOGRAPHY; GUINEA PIGS; HEART; HEART RATE; MALE; RECEPTORS, LYSOSPHINGOLIPID; THIAZOLES;

EID: 84884172324     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074285     Document Type: Article

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