Characterization of Mesenchymal Stem Cells of "No-Options" Patients with Critical Limb Ischemia Treated by Autologous Bone Marrow Mononuclear Cells

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Altaner, Cestmir ^a,b   Altanerova, Veronika ^a,b   Cihova, Marina ^a   Hunakova, Lubica ^a   Kaiserova, Katarina ^b   Klepanec, Andrej ^c   Vulev, Ivan ^c   Madaric, Juraj ^c,d  

^a CANCER RESEARCH INSTITUTE   (Slovakia)

^b St Elisabeth Cancer Institute   (Slovakia)

^c National Cardiovascular Institute   (Slovakia)

^d SLOVAK MEDICAL UNIVERSITY   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CHORIONIC GONADOTROPIN; ENDOGLIN; GOOSECOID PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; HERMES ANTIGEN; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P63; THY 1 ANTIGEN; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR OTX2; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX2; UVOMORULIN; VASCULOTROPIN RECEPTOR 2;

ADIPOCYTE; AGED; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; AUTOLOGOUS STEM CELL TRANSPLANTATION; CARTILAGE CELL; CELL AGING; CELL DIFFERENTIATION; CELL DOUBLING TIME; CELL ISOLATION; CELL PROLIFERATION; CELLULAR PARAMETERS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CRITICAL LIMB ISCHEMIA; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DIABETIC PATIENT; E CADHERIN GENE; EVENT FREE SURVIVAL; FEMALE; FOLLOW UP; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; MESENCHYMAL STEM CELL; MOLECULAR DYNAMICS; MONONUCLEAR CELL; OSTEOBLAST; OUTCOME ASSESSMENT; PARACRINE SIGNALING; PDX 1 GENE; PROTEIN EXPRESSION; SNAIL GENE;

AGED; BONE MARROW CELLS; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; HUMANS; ISCHEMIA; LEUKOCYTES, MONONUCLEAR; MALE; MESENCHYMAL STROMAL CELLS; MIDDLE AGED;

EID: 84884171885     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073722     Document Type: Article

References (30)

1. Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, et al. (2007) Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). Eur J Vasc Endovasc Surg 33 (Suppl 1)::: 1-75. doi:10.1016/S1078-5884(07)00246-8. PubMed: 17161778.
2. Kusumanto YH, van Weel V, Mulder NH, Smit AJ, van den Dungen JJ, et al. (2006) Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial. Hum Gene Ther 17: 683-691. doi:10.1089/hum.2006.17.683. PubMed: 16776576.
3. Belch J, Hiatt WR, Baumgartner I, Driver IV, Nikol S, et al. (2011) Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia. Lancet 377: 1929-1937. doi:10.1016/S0140-6736(11)60394-2. PubMed: 21621834.
4. Tateishi-Yuyama E, Matsubara H, Murohara T, Ikeda U, Shintani S, et al. (2002) Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 360: 427-435. doi:10.1016/S0140-6736(02)09670-8. PubMed: 12241713.
5. Van Tongeren RB, Hamming JF, Fibbe WE, Van Weel V, Frerichs SJ, et al. (2008) Intramuscular or combined intramuscular/intra-arterial administration of bone marrow mononuclear cells: a clinical trial in patients with advanced limb ischemia. J Cardiovasc Surg (Torino) 49: 51-58. PubMed: 18212687.
6. Matoba S, Tatsumi T, Murohara T, Imaizumi T, Katsuda Y, et al. (2008) TACT Follow-up Study Investigators. Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia. Am Heart J 156: 1010-1018. doi:10.1016/j.ahj.2008.06.025. PubMed: 19061721.
7. Amann B, Luedemann C, Ratei R, Schmidt-Lucke JA, (2009) Autologous bone marrow cell transplantation increases leg perfusion and reduces amputations in patients with advanced critical limb ischemia due to peripheral artery disease. Cell Transplant 18: 371-380. doi:10.3727/096368909788534942. PubMed: 19500466.
8. Lara-Hernandez R, Lozano-Vilardell P, Blanes P, Torreguitart-Mirada N, Galmés A, et al. (2010) Safety and efficacy of therapeutic angiogenesis as a novel treatment in patients with critical limb ischemia. Ann Vasc Surg 24: 287-294. doi:10.1016/j.avsg.2009.10.012. PubMed: 20142004.
9. Sprengers RW, Teraa M, Moll FL, de Wit GA, van der Graaf Y, et al. (2010) JUVENTAS Study Group; SMART Study Group. Quality of life in patients with no-option critical limb ischemia underlines the need for new effective treatment. J Vasc Surg 52: 843-849. doi:10.1016/j.jvs.2010.04.057. PubMed: 20598482.
10. Idei N, Soga J, Hata T, Fujii Y, Fujimura N, et al. (2011) Autologous bone-marrow mononuclear cell implantation reduces long-term major amputation risk in patients with critical limb ischemia: a comparison of atherosclerotic peripheral arterial disease and Buerger disease. Circ Cardiovasc Interv 4: 15-25. doi:10.1161/CIRCINTERVENTIONS.110.955724. PubMed: 21205941.
11. Walter DH, Krankenberg H, Balzer JO, Kalka C, Baumgartner I, et al. (2011) PROVASA Investigators Intraarterial administration of bone marrow mononuclear cells in patients with critical limb ischemia: a randomized-start, placebo-controlled pilot trial (PROVASA). Circ Cardiovasc Interv 4: 26-37. doi:10.1161/CIRCINTERVENTIONS.110.958348. PubMed: 21205939.
12. Schiavetta A, Maione C, Botti C, Marino G, Lillo S, et al. (2012) A phase II trial of autologous transplantation of bone marrow stem cells for critical limb ischemia: results of the Naples and Pietra Ligure Evaluation of Stem Cells study. Stem Cells. J Transl Med 1: 572-578.
13. Benoit E, O'Donnell TF Jr, Patel AN, (2013) Safety and efficacy of autologous cell therapy in critical limb ischemia: a systematic review of the literature. Cell Transplant 22: 545-562. doi:10.3727/096368912X636777. PubMed: 22490340.
14. Lu D, Chen B, Liang Z, Deng W, Jiang Y, et al. (2011) Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial. Diabetes Res Clin Pract 92: 26-36. doi:10.1016/j.diabres.2010.12.010. PubMed: 21216483.
15. Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, et al. (2010) Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells 28: 2229-2238. doi:10.1002/stem.544. PubMed: 20945332.
16. Klepanec A, Mistrik M, Altaner C, Valachovicova M, Olejarova I, et al. (2012) No Difference in Intraarterial and Intramuscular Delivery of Autologous Bone-Marrow Cells in Patients with Advanced Critical Limb Ischemia. Cell Transplant 21: 1909-1918. doi:10.3727/096368912X636948. PubMed: 22472173.
17. Altanerova V, Cihova M, Babic M, Rychly B, Ondicova K, et al. (2012) Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma. Int J Cancer; 130: 2455-2463. doi:10.1002/ijc.26278. PubMed: 21732344.
18. Cihova M, Altanerova V, Altaner C, (2011) Stem cell based cancer gene therapy. Mol Pharm 8: 1480-1487. doi:10.1021/mp200151a. PubMed: 21755953.
19. Kirana S, Stratmann B, Prante C, Prohaska W, Koerperich H, et al. (2012) Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients. Int J Clin Pract 66: 384-393. doi:10.1111/j.1742-1241.2011.02886.x. PubMed: 22284892.
20. Kinnaird T, Stabile E, Burnett MS, Lee CW, Barr S, et al. (2004) Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 94: 678-685. doi:10.1161/01.RES.0000118601.37875.AC. PubMed: 14739163.
21. Chen L, Tredget EE, Wu PY, Wu Y, (2008) Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLOS ONE 3: e1886. doi:10.1371/journal.pone.0001886. PubMed: 18382669.
22. Bouffi C, Bony C, Courties G, Jorgensen C, Noël D, (2010) IL-6-dependent PGE2 secretion by mesenchymal stem cells inhibits local inflammation in experimental arthritis. PLOS ONE 5: e14247. doi:10.1371/journal.pone.0014247. PubMed: 21151872.
23. DiPietro LA, Burdick M, Low QE, Kunkel SL, Strieter RM, (1998) MIP-1alpha as a critical macrophage chemoattractant in murine wound repair. J Clin Invest 101: 1693-1698. doi:10.1172/JCI1020.
24. Boomsma RA, Geenen DL, (2012) Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosis. PLOS ONE 7: e35685. doi:10.1371/journal.pone.0035685.
25. Akiyama K, Chen C, Wang D, Xu X, Qu C, et al. (2012) Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell 10: 544-555. doi:10.1016/j.stem.2012.03.007.
26. Tang Y, Cui YC, Wang XJ, Wu AL, Hu GF, et al. (2012) Neural progenitor cells derived from adult bone marrow mesenchymal stem cells promote neuronal regeneration. Life Sci 91: 951-958. doi:10.1016/j.lfs.2012.09.005.
27. Otsuru S, Gordon PL, Shimono K, Jethva R, Marino R, et al. (2012) Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms. Blood 120: 1933-1941. doi:10.1182/blood-2011-12-400085.
28. Lee HC, An SG, Lee HW, Park JS, Cha KS, et al. (2012) Safety and effect of adipose tissue-derived stem cell implantation in patients with critical limb ischemia: a pilot study. Circ J 76: 1750-1760. doi:10.1253/circj.CJ-11-1135.
29. Shen WC, Liang CJ, Wu VC, Wang SH, Young GH, et al. (2013) Endothelial progenitor cells derived from Wharton's jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression. Stem Cells Dev 22(9):: 1408-1418. doi:10.1089/scd.2012.0445.
30. Le Blanc C, Tammik K, Rosendahl E, Zetterberg Ringdén O, (2003) HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 10: 890-896.