Hydrogel blends with adjustable properties as patches for transdermal delivery

International Journal of Pharmaceutics

Volumn 454, Issue 1, 2013, Pages 47-57

  Mazzitelli, Stefania ^a   Pagano, Cinzia ^b   Giusepponi, Danilo ^b   Nastruzzi, Claudio ^a   Perioli, Luana ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Gelatin; Hydrogels; Pectin; Transdermal delivery formulation

Indexed keywords

GELATIN; PECTIN; TESTOSTERONE;

AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; DRUG FORMULATION; DRUG RELEASE; ELASTICITY; FLOW KINETICS; FLOW MEASUREMENT; GELATION; HYDROGEL; IN VITRO STUDY; OSCILLATION; PARTICLE SIZE; PRIORITY JOURNAL; SHELF LIFE; SOLUBILIZATION; TESTOSTERONE RELEASE; TRANSDERMAL PATCH;

EID: 84884169259     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.06.081     Document Type: Article

References (24)

1. Bao, Y., Senos, A.M., Almeida, M., Gauckler, L.J., 2002. Rheological behaviour of aqueous suspendions of hydroxyapatite (HAP). J. Mater. Sci. 13, 639-643. (Pubitemid 34734582)
2. Berti, J.J., Lipsky, J.J., 1995. Transcutaneous drug delivery: a practical review. Mayo Clin. Proc. 70, 581-586.
3. Brown, M.B., Martin, G.P., Jones, S.A., Akomeah, F.K., 2006. Dermal and transdermal drug delivery systems: current and future prospects. Drug Deliv. 13, 175-187.
4. EMA, 2012. Guideline on quality of transdermal patches.
5. Geurts, T.B.P., Coelingh Bennink, H.J.T., 2000. Testosterone replacement therapy: testosterone undecanoate (Andriol). J. Urol. Uroge., 24-35, Special Edition.
6. Hoffman, A.S., 2012. Hydrogels for biomedical applications. Adv. Drug Deliv. Rev. 54, 3-12.
7. Houwing, N.S., Maris, F., Schnabel, P.G., Bagchus, W.M., 2003. Pharmacokinetic study in women of three different doses of a new formulation of oral testosterone undecanoate. Andriol Testocaps. Pharmacother. 23, 1257-1265. (Pubitemid 37221921)
8. Kandavilli, S., Nair, V., Panchagnula, R., 2002. Polymers in transdermal drug delivery systems. Pharm. Technol., 62-80.
9. Lee, S.K., Knighton, S., 2008. Scenario 4: choice of hormone replacement therapy (HRT). In: North-Lewis, P. (Ed.), Drugs and the Liver. Pharmaceutical Press, London, pp. 257-274.
10. Lengálová, A., Pavliǐnek, V., Sáha, P., Quadrat, O., Stejskal, J., 2003. The effect of dispersedparticlesize and shape on the electrorheological behaviour of suspensions. Colloids Surf. A 227, 1-8.
11. Liu, L., Fishman, M.L., Kost, J., Hicks, K.B., 2003. Pectin-based systems for colon-specific drugdelivery via oral route. Biomaterials 24, 3333-3343. (Pubitemid 36581891)
12. Luca, G., Calvitti, M., Nastruzzi, C., Bilancetti, L., Becchetti, E., Angeletti, G., Mancuso, F., Calafiore, R., 2007. Encapsulation, in vitro characterization and in vivo biocompatibility of Sertoli's cells in alginate based microcapsules. Tissue Eng. 13, 641-648. (Pubitemid 46579889)
13. Mazzitelli, S., Capretto, L., Carugo, D., Zhang, X., Piva, R., Nastruzzi, C., Optimised production of multifunctional microfibres by microfluidic chip technology for tissue engineering applications. Lab Chip 21, 1776-1785.
14. Mazzitelli, S., Tosi, A., Balestra, C., Nastruzzi, C., Luca, G., Mancuso, F., Calafiore, R., Calvitti, M., 2008. Production and characterization of alginate microcapsules produced by a vibrational encapsulation device. J. Biomater. Appl. 23, 123-145.
15. ++ on alginate microbeads. Biomacromolecules 7, 1471-1480.
16. Patankar, N.A., Hu, H.H., 2001. Rheology of a suspension of particles in viscoelastic fluids. J. Non-Newtonian Fluid Mech. 96, 427-443.
17. Peppas, N.A., Bures, P., Leobandung, W., Ichikawa, H., 2000. Hydrogels in pharmaceutical formulations. Eur. J. Pharm. Biopharm. 50, 27-46. (Pubitemid 30326687)
18. Prausnitz, M.R., Langer, R., 2008. Transdermal drug delivery. Nat. Biotechnol. 26, 1261-1268.
19. Rathna, G.V.N., 2008. Gelatin hydrogels: enhanced biocompatibility, drug release and cell viability. J. Mater. Sci. Mater. Med. 19, 2351-2358.
20. Ritger, P., Peppas, N.A., 1987. A simple equation for description of solute release, II: Fickian and anomalous release from swellable devices. J. Control. Release 5, 37-42. (Pubitemid 17106644)
21. Subedi, R.K., Oh, S.Y., Chun, M.K., Choi, H.K., 2010. Recent advances in transdermal drug delivery. Arch. Pharm. Res. 33, 339-351.
22. Ueda, C.T., Shah, V.P., Derdzinski, K., Ewing, G., Flynn, G., Maibach, H., Marques, M., Rytting, H., Shaw, S., Thakker, K., Yacobi, A., 2009. Topical and transdermal drug products. Pharmacopeial Forum 35, 750-764.
23. Wokovich, A.M., Prodduturi, S., Doub, W.H., Hussain, A.S., Buhse, L.F., 2006. Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute. Eur. J. Pharm. Biopharm. 64, 1-8. (Pubitemid 44150598)
24. Yoo, J.W., Lee, C.H., 2006. Drug delivery systems for hormone therapy. J. Control. Release 112, 1-14.