An Intragenic SRF-Dependent Regulatory Motif Directs Cardiac-Specific microRNA-1-1/133a-2 Expression

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Li, Qi ^a   Guo, Junli ^a   Lin, Xi ^c   Yang, Xiangsheng ^c   Ma, Yanlin ^a   Fan, Guo Chang ^b   Chang, Jiang ^c  

^a HAINAN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA 1; MICRORNA 1 1; MICRORNA 133A 2; SERUM RESPONSE FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA SEQUENCE; DROSOPHILA; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE INSERTION; HEART MUSCLE; LACZ GENE; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN MOTIF; REPORTER GENE; SKELETAL MUSCLE; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; YEAST;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; MICE; MICE, TRANSGENIC; MICRORNAS; MYOBLASTS, CARDIAC; MYOCARDIUM; ORGAN SPECIFICITY; SERUM RESPONSE ELEMENT;

EID: 84884165217     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075470     Document Type: Article

References (32)

1. Norman C, Runswick M, Pollock R, Treisman R, (1988) Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Cell 55: 989-1003. doi:10.1016/0092-8674(88)90244-9. PubMed: 3203386.
2. Treisman R, (1994) Ternary complex factors: growth factor regulated transcriptional activators. Curr Opin Genet Dev 4: 96-101. doi:10.1016/0959-437X(94)90097-3. PubMed: 8193547.
3. Miano JM, (2003) Serum response factor: toggling between disparate programs of gene expression. J Mol Cell Cardiol 35: 577-593. doi:10.1016/S0022-2828(03)00110-X. PubMed: 12788374.
4. Lee TC, Schwartz RJ, (1992) Using proteases to avoid false identification of DNA-protein complexes in gel shift assays. BioTechniques 12: 486-490. PubMed: 1503744.
5. Li L, Liu Z, Mercer B, Overbeek P, Olson EN, (1997) Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells. Dev Biol 187: 311-321. doi:10.1006/dbio.1997.8621. PubMed: 9242426.
6. Chen CY, Schwartz RJ, (1997) Competition between negative acting YY1 versus positive acting serum response factor and tinman homologue Nkx-2.5 regulates cardiac alpha-actin promoter activity. Mol Endocrinol 11: 812-822. doi:10.1210/me.11.6.812. PubMed: 9171244.
7. Chen CY, Schwartz RJ, (1996) Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription. Mol Cell Biol 16: 6372-6384. PubMed: 8887666.
8. Li S, Czubryt MP, McAnally J, Bassel-Duby R, Richardson JA, et al. (2005) Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A 102: 1082-1087. doi:10.1073/pnas.0409103102. PubMed: 15647354.
9. Niu Z, Yu W, Zhang SX, Barron M, Belaguli NS, et al. (2005) Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem 280: 32531-32538. doi:10.1074/jbc.M501372200. PubMed: 15929941.
10. Miano JM, Ramanan N, Georger MA, de Mesy Bentley KL, Emerson RL, et al. (2004) Restricted inactivation of serum response factor to the cardiovascular system. Proc Natl Acad Sci U S A 101: 17132-17137. doi:10.1073/pnas.0406041101. PubMed: 15569937.
11. Parlakian A, Tuil D, Hamard G, Tavernier G, Hentzen D, et al. (2004) Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. Mol Cell Biol 24: 5281-5289. doi:10.1128/MCB.24.12.5281-5289.2004. PubMed: 15169892.
12. Arsenian S, Weinhold B, Oelgeschläger M, Rüther U, Nordheim A, (1998) Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J 17: 6289-6299. doi:10.1093/emboj/17.21.6289. PubMed: 9799237.
13. Wiebel FF, Rennekampff V, Vintersten K, Nordheim A, (2002) Generation of mice carrying conditional knockout alleles for the transcription factor SRF. Genesis 32: 124-126. doi:10.1002/gene.10049. PubMed: 11857797.
14. Schratt G, Philippar U, Berger J, Schwarz H, Heidenreich O, et al. (2002) Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. J Cell Biol 156: 737-750. doi:10.1083/jcb.200106008. PubMed: 11839767.
15. Schratt G, Weinhold B, Lundberg AS, Schuck S, Berger J, et al. (2001) Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells. Mol Cell Biol 21: 2933-2943. doi:10.1128/MCB.21.8.2933-2943.2001. PubMed: 11283270.
16. Weinhold B, Schratt G, Arsenian S, Berger J, Kamino K, et al. (2000) Srf(-/-) ES cells display non-cell-autonomous impairment in mesodermal differentiation. EMBO J 19: 5835-5844. doi:10.1093/emboj/19.21.5835. PubMed: 11060034.
17. Chang J, Wei L, Otani T, Youker KA, Entman ML, et al. (2003) Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading. Circulation 108: 407-413. doi:10.1161/01.CIR.0000084502.02147.83. PubMed: 12874181.
18. Yang X, Li Q, Lin X, Ma Y, Yue X, et al. (2012) Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1. FASEB J 26: 2105-2116. doi:10.1096/fj.11-201319. PubMed: 22278938.
19. Lin X, Yang X, Li Q, Ma Y, Cui S, et al. (2012) Protein Tyrosine Phosphatase-Like A Regulates Myoblast Proliferation and Differentiation through MyoG and the Cell Cycling Signaling Pathway. Mol Cell Biol 32: 297-308. doi:10.1128/MCB.05484-11. PubMed: 22106411.
20. Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, et al. (2006) The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet 38: 228-233. doi:10.1038/ng1725. PubMed: 16380711.
21. Townley-Tilson WH, Callis TE, Wang D, (2010) MicroRNAs. p. 1, 133 and 206: critical factors of skeletal and cardiac muscle development, function, and disease. Int J Biochem Cell Biol 42: 1252-1255.
22. Kusakabe R, Tani S, Nishitsuji K, Shindo M, Okamura K, et al. (2013) Characterization of the compact bicistronic microRNA precursor, miR-1/miR-133, expressed specifically in Ciona muscle tissues. Gene Expr Patterns 13: 43-50. doi:10.1016/j.gep.2012.11.001. PubMed: 23159539.
23. Liu N, Bezprozvannaya S, Williams AH, Qi X, Richardson JA, et al. (2008) microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev 22: 3242-3254. doi:10.1101/gad.1738708. PubMed: 19015276.
24. Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M, (2007) MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 100: 416-424. doi:10.1161/01.RES.0000257913.42552.23. PubMed: 17234972.
25. Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, et al. (2007) MicroRNA-133 controls cardiac hypertrophy. Nat Med 13: 613-618. doi:10.1038/nm1582. PubMed: 17468766.
26. Zhao Y, Samal E, Srivastava D, (2005) Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 436: 214-220. doi:10.1038/nature03817. PubMed: 15951802.
27. Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, et al. (2007) Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 129: 303-317. doi:10.1016/j.cell.2007.03.030. PubMed: 17397913.
28. Li Q, Lin X, Yang X, Chang J, (2010) NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression. Am J Physiol Heart Circ Physiol 298: H1340-H1347. doi:10.1152/ajpheart.00592.2009. PubMed: 20173049.
29. Duisters RF, Tijsen AJ, Schroen B, Leenders JJ, Lentink V, et al. (2009) miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res 104: 170-178. doi:10.1161/CIRCRESAHA.108.182535. PubMed: 19096030.
30. Matkovich SJ, Wang W, Tu Y, Eschenbacher WH, Dorn LE, et al. (2009) MicroRNA-133a Protects Against Myocardial Fibrosis and Modulates Electrical Repolarization Without Affecting Hypertrophy in Pressure-Overloaded Adult Hearts. Circ Res, 106: 166-75. PubMed: 19893015.
31. Xiao J, Luo X, Lin H, Zhang Y, Lu Y, et al. (2007) MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. J Biol Chem 282: 12363-12367. doi:10.1074/jbc.C700015200. PubMed: 17344217.
32. Liu N, Williams AH, Kim Y, McAnally J, Bezprozvannaya S, et al. (2007) An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci U S A 104: 20844-20849. doi:10.1073/pnas.0710558105. PubMed: 18093911.