Efficacy of two FDA-approved drug combination in a mouse model of staphylococcal enterotoxin B-induced shock

Military Medicine

Volumn 178, Issue 9, 2013, Pages 1024-1028

  Krakauer, Teresa ^a   Buckley, Marilyn ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIINFLAMMATORY AGENT; DEXAMETHASONE; ENTEROTOXIN; ENTEROTOXIN B, STAPHYLOCOCCAL; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; SCAVENGER;

ANIMAL; ARTICLE; BLOOD; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG COMBINATION; FEMALE; LUNG; MALE; METABOLISM; MOUSE; SEPTIC SHOCK;

ACETYLCYSTEINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CHEMOKINE CCL2; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ENTEROTOXINS; FEMALE; FREE RADICAL SCAVENGERS; INTERFERON-GAMMA; INTERLEUKIN-2; INTERLEUKIN-6; LUNG; MALE; MICE; SHOCK, SEPTIC;

EID: 84884152052     PISSN: 00264075     EISSN: 1930613X     Source Type: Journal    
DOI: 10.7205/MILMED-D-13-00129     Document Type: Article

References (30)

1. Fraser JD, Proft T: The bacterial superantigen and superantigen-like proteins. Immunol Rev 2008; 225: 226-243.
2. Holmberg SD, Blake PA: Staphylococcal food poisoning in the United States. New facts and old misconceptions. JAMA 1984; 251: 487-489.
3. Kotzin BL, Leung DYM, Kappler J, Marrack PA: Superantigens and their potential role in human disease. Adv Immunol 1993; 54: 99-166.
4. Le Loir Y, Baron F, Gautier M: Staphylococcus aureus and food poisoning. Genet Mol Res 2003; 2: 63-76.
5. McKay DM: Bacterial superantigens: provocateurs of gut dysfunction and inflammation? Trends Immunol 2001; 22: 497-501.
6. Brocke S, Hausmann S, Steinmam L, Wucherpfennig KW: Microbial peptides and superantigens in the pathogenesis of autoimmune diseases of the central nervous system. Semin Immunol 1998; 10: 57-67.
7. Choi Y, Kotzin BL, Hernon L, Callahan J, Marrack PA, Kappler J: Interaction of Staphyloccocus aureus toxin "superantigens" with human T cells. Proc Natl Acad Sci USA 1989; 86: 8941-8945.
8. Marrack P, Kappler J: The staphylococcal enterotoxins and their relatives. Science 1990; 248: 705-711.
9. McCormick JK., Yarwood JM, and Schlievert PM: Toxic shock syndrome and bacterial superantigens: an update. Annu Rev Microbiol 2001; 55: 77-104.
10. Miethke T, Wahl C, Heeg K, Echtenacher B, Krammer PH, Wagner H: T cell-mediated lethal shock triggered in mice by the superantigen SEB: critical role of TNF. J Exp Med 1992; 175: 91-98.
11. Tessier PA, Naccache PH, Diener KR, et al: Induction of acute inflammation in vivo by staphylococcal superantigens. II. Critical role for chemokines, ICAM-1, and TNF-alpha. J Immunol 1998; 161: 1204-1211.
12. Neumann B, Engelhardt B, Wagner H, Holzmann B: Induction of acute inflammatory lung injury by staphylococcal enterotoxin B. J Immunol 1997; 158: 1862-1871.
13. Llewelyn M, Cohen J: Superantigens: microbial agents that corrupt immunity. Lancet Infect Dis 2002; 2: 156-162.
14. Krakauer T, Vilcek J, Oppenheim JJ: TNF family cytokines, chemokines and other proor anti-inflammatory cytokines. In: Fundamental Immunology, Ed 4, pp 783-811. Edited by Paul WE. Philadelphia, PA, Lippincott-Raven Publishers, 1999.
15. Ulrich RG, Wilhelmsen CL, Krakauer T: Staphylococcal enterotoxin B and related toxins. In: Textbook of Military Medicine, Medical Aspects of Biological Warfare, pp 311-322. Edited by Dembek Z. Washington, DC, US Department of Army and Borden Institute, 2007.
16. Darenberg J, Soderquist B, Normark BH, Norrby-Tegland AA: Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens: implications for therapy of toxic shock syndrome. Clin Infect Dis 2004; 38: 836-842.
17. Krakauer T: Therapeutic down-modulators of staphylococcal superantigeninduced inflammation and toxic shock. Toxins 2010; 2: 1963-1983.
18. Sprung CL, Goodman S, Weiss YG: Steroid therapy of septic shock. Crit Care Clin 2009. 25: 825-834.
19. Annane D, Bellissant E, Bollaert PE, Briegel JB, Keh D, Kupfer Y: Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ 2004; 329: 480-489.
20. Krakauer, T: Differential inhibitory effects of interleukin-10, interleukin-4, and dexamethasone on staphylococcal enterotoxin-induced cytokine production and T cell activation. J Leukoc Biol 1995; 57: 450-454.
21. Krakauer T, Buckley M, Huzella LM, Alves DA: Critical timing, location and duration of glucocorticoid administration rescues mice from superantigen-induced shock and attenuates lung injury. Int Immunopharmacol 2009; 9: 1168-1174.
22. Qu X, Li Q, Wang X, Yang X, Wang D. N-acetylcysteine attenuates cardiopulmonary bypass-induced lung injury in dogs. J Cardiothorac Surg 2013; 22: 107-122.
23. Samuni Y, Goldstein S, Dean OM, Berk M: The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta 2013; 1830: 4117-4129.
24. Andrews NP, Prasad A, Quyyumi AA: N-acetylcysteine improves coronary and peripheral vascular function. J Am Coll Cardiol 2001; 37: 117-123.
25. Wineyard PG, Blake DR: Antioxidants, redox-regulated transcription factors, and inflammation. Adv Pharmacol 1997; 38: 403-421.
26. Krakauer T, Buckley M: The potency of antioxidants in attenuating superantigen-induced proinflammatory cytokines correlates with inactivation of NF-kB. Immunopharmacol Immunotoxicol 2008; 30: 163-179.
27. Huzella LM, Buckley MJ, Alves DA, Stiles BG, Krakauer T: Central roles for IL-2 and MCP-1 following intranasal exposure to SEB: a new mouse model. Res Vet Sci 2009; 86: 241-247.
28. Vlack KD, Boles JW, Stiles BG: Telemetric evaluation of body temperature and physical activity as predictors of mortality in a murine model of staphylococcal enterotoxic shock. Comp Med 2000; 50: 160-166.
29. Madsen JM: Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agents. Clin Lab Med 2001; 21: 593-605.
30. Tang YW, Stratton CW: Staphylococcus aureus: an old pathogen with new weapons. Clin Lab Med 2010; 30: 179-208.