Memory decline shows stronger associations with estimated spatial patterns of amyloid deposition progression than total amyloid burden

Neurobiology of Aging

Volumn 34, Issue 12, 2013, Pages 2835-2842

  Yotter, Rachel A ^a   Doshi, Jimit ^a   Clark, Vanessa ^a   Sojkova, Jitka ^b,c   Zhou, Yun ^c   Wong, Dean F ^c   Ferrucci, Luigi ^b   Resnick, Susan M ^b   Davatzikos, Christos ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloid; Cognition; CVLT; PET; PiB

Indexed keywords

AMYLOID PROTEIN; BIOLOGICAL MARKER; PITTSBURGH COMPOUND B;

AGED; AMNESIA; AMYLOID PLAQUE; ARTICLE; AUTOPSY; BRAIN; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FRONTAL CORTEX; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEMORY; MENTAL DETERIORATION; MENTAL PERFORMANCE; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRECUNEUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN METABOLISM; SENSORIMOTOR CORTEX; TEMPORAL CORTEX;

AMYLOID; COGNITION; CVLT; PET; PIB;

AGED; AGED, 80 AND OVER; AMYLOIDOGENIC PROTEINS; ANILINE COMPOUNDS; BIOLOGICAL MARKERS; CARBON RADIOISOTOPES; CEREBRAL CORTEX; COGNITION DISORDERS; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MEMORY; MOLECULAR IMAGING; RADIOPHARMACEUTICALS; THIAZOLES; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 84884135317     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.05.030     Document Type: Article

References (44)

1. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical andpowerful approach to multiple testing. J. R. Stat. Soc. Series. B Methodol. 1995, 57:289-300.
2. Blessed G., Tomlinson B.E., Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br. J. Psychiatry 1968, 114:797-811.
3. Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991, 82:239-259.
4. Braak H., Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol. Aging 1997, 18:351-357.
5. Braak H., Braak E. Staging of Alzheimer-related cortical destruction. Int. Psychogeriatr. 1997, 9:257-261.
6. Chetelat G., Villemagne V.L., Pike K.E., Ellis K.A., Bourgeat P., Jones G., O'Keefe G.J., Salvado O., Szoeke C., Martins R.N., Ames D., Masters C.L., Rowe C.C., the Australian Imaging B, Lifestyle Study of ageing Research G Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease. Brain 2011, 134:798-807.
7. Clark V.H., Resnick S.M., Doshi J., Beason-Held L.L., Zhou Y., Ferrucci L., Wong D.F., Kraut M.A., Davatzikos C. Longitudinal imaging pattern analysis (SPARE-CD index) detects early structural and functional changes prior to cognitive decline in healthy older adults. Neurobiol. Aging 2012, 33:2733-2745.
8. Delis D.C., Kramer J.H., Kaplan E., Ober B.A. California Verbal Learning Test-Research Edition 1987, Psychological Corporation, New York.
9. Dickerson B.C., Wolk D.A. MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults. Neurology 2012, 78:84-90.
10. Engler H., Forsberg A., Almkvist O., Blomquist G., Larsson E., Savitcheva I., Wall A., Ringheim A., Langstrom B., Nordberg A. Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain 2006, 129:2856-2866.
11. Forsberg A., Almkvist O., Engler H., Wall A., Langstrom B., Nordberg A. High PIB retention in Alzheimers disease is an early event with complex relationship with CSF biomarkers and functional parameters. Curr. Alzheimer Res. 2010, 7:56-66.
12. Forsberg A., Engler H., Almkvist O., Blomquist G., Hagman G., Wall A., Ringheim A., Langstrom B., Nordberg A. PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiol. Aging 2008, 29:1456-1465.
13. Grimmer T., Henriksen G., Wester H.-J., Förstl H., Klunk W.E., Mathis C.A., Kurz A., Drzezga A. Clinical severity of Alzheimer's disease is associated with PIB uptake in PET. Neurobiol. Aging 2009, 30:1902-1909.
14. Grober E., Hall C.B., Lipton R.B., Zonderman A.B., Resnick S.M., Kawas C. Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease. J. Int. Neuropsychol. Soc. 2008, 14:266-278.
15. Hardy J. The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. J. Neurochem. 2009, 110:1129-1134.
16. Jack C.R., Knopman D.S., Jagust W.J., Shaw L.M., Aisen P.S., Weiner M.W., Petersen R.C., Trojanowski J.Q. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 2010, 9:119-128.
17. Jack C.R., Lowe V.J., Senjem M.L., Weigand S.D., Kemp B.J., Shiung M.M., Knopman D.S., Boeve B.F., Klunk W.E., Mathis C.A., Petersen R.C. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain 2008, 131:665-680.
18. Jack C.R., Lowe V.J., Weigand S.D., Wiste H.J., Senjem M.L., Knopman D.S., Shiung M.M., Gunter J.L., Boeve B.F., Kemp B.J., Weiner M., Petersen R.C., the Alzheimer's Disease Neuroimaging I Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain 2009, 132:1355-1365.
19. Kadir A., Almkvist O., Forsberg A., Wall A., Engler H., Långström B., Nordberg A. Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease. Neurobiol. Aging 2010, 33:198.e1-198.e14.
20. Klunk W.E., Engler H., Nordberg A., Wang Y., Blomqvist G., Holt D.P., Bergström M., Savitcheva I., Huang G.-F., Estrada S., Ausén B., Debnath M.L., Barletta J., Price J.C., Sandell J., Lopresti B.J., Wall A., Koivisto P., Antoni G., Mathis C.A., Långström B. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann. Neurol. 2004, 55:306-319.
21. Lockhart A., Lamb J.R., Osredkar T., Sue L.I., Joyce J.N., Ye L., Libri V., Leppert D., Beach T.G. PIB is a non-specific imaging marker of amyloid-beta (Aβ) peptide-related cerebral amyloidosis. Brain 2007, 130:2607-2615.
22. Lopresti B.J., Klunk W.E., Mathis C.A., Hoge J.A., Ziolko S.K., Lu X., Meltzer C.C., Schimmel K., Tsopelas N.D., DeKosky S.T., Price J.C. Simplified quantification of Pittsburgh compound B amyloid imaging PET studies: a comparative analysis. J. Nucl. Med. 2005, 46:1959-1972.
23. Meltzer C.C., Leal J.P., Mayberg H.S., Wagner H.N., Frost J.J. Correction of PET data for partial volume effects in human cerebral cortex by MR imaging. J. Comput. Assist. Tomog. 1990, 14:561-570.
24. Mintun M.A., LaRossa G.N., Sheline Y.I., Dence C.S., Lee S.Y., Mach R.H., Klunk W.E., Mathis C.A., DeKosky S.T., Morris J.C. [11C]PIB in a nondemented population. Neurology 2006, 67:446-452.
25. Mormino E.C., Kluth J.T., Madison C.M., Rabinovici G.D., Baker S.L., Miller B.L., Koeppe R.A., Mathis C.A., Weiner M.W., Jagust W.J., the Alzheimer's Disease Neuroimaging I Episodic memory loss is related to hippocampal-mediated β-amyloid deposition in elderly subjects. Brain 2009, 132:1310-1323.
26. Morris J.C. Clinical Dementia Rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. Int. Psychogeriatr. 1997, 9:173-176.
27. Nordberg A., Rinne J.O., Kadir A., Langstrom B. The use of PET in Alzheimer disease. Nat. Rev. Neurol. 2010, 6:78-87.
28. Pike K.E., Savage G., Villemagne V.L., Ng S., Moss S.A., Maruff P., Mathis C.A., Klunk W.E., Masters C.L., Rowe C.C. β-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain 2007, 130:2837-2844.
29. Price J.C., Klunk W.E., Lopresti B.J., Lu X., Hoge J.A., Ziolko S.K., Holt D.P., Meltzer C.C., DeKosky S.T., Mathis C.A. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J. Cereb. Blood Flow Metab. 2005, 25:1528-1547.
30. Rentz D.M., Amariglio R.E., Becker J.A., Frey M., Olson L.E., Frishe K., Carmasin J., Maye J.E., Johnson K.A., Sperling R.A. Face-name associative memory performance is related to amyloid burden in normal elderly. Neuropsychologia 2011, 49:2776-2783.
31. Resnick S., Sojkova J. Amyloid imaging and memory change for prediction of cognitive impairment. Alzheimer's Res. Ther. 2011, 3:1-9.
32. Resnick S.M., Sojkova J., Zhou Y., An Y., Ye W., Holt D.P., Dannals R.F., Mathis C.A., Klunk W.E., Ferrucci L., Kraut M.A., Wong D.F. Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB. Neurology 2010, 74:807-815.
33. Rowe C.C., Ackerman U., Browne W., Mulligan R., Pike K.L., O'Keefe G., Tochon-Danguy H., Chan G., Berlangieri S.U., Jones G., Dickinson-Rowe K.L., Kung H.P., Zhang W., Kung M.P., Skovronsky D., Dyrks T., Holl G., Krause S., Friebe M., Lehman L., Lindemann S., Dinkelborg L.M., Masters C.L., Villemagne V.L. Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol. 2008, 7:129-135.
34. Rowe C.C., Ng S., Ackermann U., Gong S.J., Pike K., Savage G., Cowie T.F., Dickinson K.L., Maruff P., Darby D., Smith C., Woodward M., Merory J., Tochon-Danguy H., O'Keefe G., Klunk W.E., Mathis C.A., Price J.C., Masters C.L., Villemagne V.L. Imaging β-amyloid burden in aging and dementia. Neurology 2007, 68:1718-1725.
35. Shoghi-Jadid K., Small G.W., Agdeppa E.D., Kepe V., Ercoli L.M., Siddarth P., Read S., Satyamurthy N., Petric A., Huang S.-C., Barrio J.R. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am. J. Geriatr. Psychiatry 2002, 10.
36. Sojkova J., Beason-Held L., Zhou Y., An Y., Kraut M.A., Ye W., Ferrucci L., Mathis C.A., Klunk W.E., Wong D.F., Resnick S.M. Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?. J. Nucl. Med. 2008, 49:1465-1471.
37. Sojkova J., Zhou Y., An Y., Kraut M.A., Ferrucci L., Wong D.F., Resnick S.M. Longitudinal patterns of β-amyloid deposition in nondemented older adults. Arch. Neurol. 2011, 68:644-649.
38. Storandt M., Mintun M.A., Head D., Morris J.C. Cognitive decline and brain volume loss as signatures of cerebral amyloid-β peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Aβ deposition. Arch. Neurol. 2009, 66:1476-1481.
39. Villemagne V.L., Pike K.E., Chételat G., Ellis K.A., Mulligan R.S., Bourgeat P., Ackermann U., Jones G., Szoeke C., Salvado O., Martins R., O'Keefe G., Mathis C.A., Klunk W.E., Ames D., Masters C.L., Rowe C.C. Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease. Ann. Neurol. 2011, 69:181-192.
40. Villemagne V.L., Pike K.E., Darby D., Maruff P., Savage G., Ng S., Ackermann U., Cowie T.F., Currie J., Chan S.G., Jones G., Tochon-Danguy H., O'Keefe G., Masters C.L., Rowe C.C. Aβ deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease. Neuropsychologia 2008, 46:1688-1697.
41. Vlassenko A.G., Vaishnavi S.N., Couture L., Sacco D., Shannon B.J., Mach R.H., Morris J.C., Raichle M.E., Mintun M.A. Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition. Proc. Nat. Acad. Sci. U.S.A 2010, 107:17763-17767.
42. Wong D.F., Rosenberg P.B., Zhou Y., Kumar A., Raymont V., Ravert H.T., Dannals R.F., Nandi A., Brašić J.R., Ye W., Hilton J., Lyketsos C., Kung H.F., Joshi A.D., Skovronsky D.M., Pontecorvo M.J. in vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (Flobetapir F 18). J. Nucl. Med. 2010, 51:913-920.
43. Zhou Y., Endres C.J., Brašić J.R., Huang S.-C., Wong D.F. Linear regression with spatial constraint to generate parametric images of ligand-receptor dynamic PET studies with a simplified reference tissue model. NeuroImage 2003, 18:975-989.
44. Zhou Y., Resnick S.M., Ye W., Fan H., Holt D.P., Klunk W.E., Mathis C.A., Dannals R., Wong D.F. Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease. NeuroImage 2007, 36:298-312.