Longitudinal imaging pattern analysis (SPARE-CD index) detects early structural and functional changes before cognitive decline in healthy older adults

Neurobiology of Aging

Volumn 33, Issue 12, 2012, Pages 2733-2745

  Clark, Vanessa H ^a   Resnick, Susan M ^b   Doshi, Jimit ^a   Beason Held, Lori L ^b   Zhou, Yun ^c   Ferrucci, Luigi ^b   Wong, Dean F ^c   Kraut, Michael A ^c   Davatzikos, Christos ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Classification; Cognitive impairment; Magnetic resonance imaging; Positron emission tomography; Support vector machines

Indexed keywords

BIOLOGICAL MARKER; PITTSBURGH COMPOUND B;

ADULT; AGED; AGING; ARTICLE; BRAIN BLOOD FLOW; CLASSIFICATION ALGORITHM; COGNITIVE DEFECT; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; EARLY DIAGNOSIS; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; LEARNING TEST; MAJOR CLINICAL STUDY; MALE; NEUROANATOMY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATTERN RECOGNITION; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PRIORITY JOURNAL; SCORING SYSTEM; SPATIAL PATTERN OF ABNORMALITY FOR RECOGNITION OF EARLY COGNITIVE DECLINE INDEX; VOXEL BASED MORPHOMETRY;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ANILINE COMPOUNDS; BRAIN; BRAIN MAPPING; CEREBROVASCULAR CIRCULATION; COGNITION DISORDERS; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; STATISTICS AS TOPIC; THIAZOLES;

EID: 84866762117     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.01.010     Document Type: Article

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