Tissue transglutaminase mediates the pro-malignant effects of oncostatin M receptor over-expression in cervical squamous cell carcinoma

Journal of Pathology

Volumn 231, Issue 2, 2013, Pages 168-179

  Caffarel, Maria M ^a   Chattopadhyay, Anasuya ^a   Araujo, Angela M ^a   Bauer, Julien ^a   Scarpini, Cinzia G ^a   Coleman, Nicholas ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

cell migration; fibronectin; integrin 5 1; invasion; oncostatin M receptor; squamous cell carcinoma; tissue transglutaminase

Indexed keywords

ALPHA5 INTEGRIN; ALPHAVBETA1 INTEGRIN; FIBRONECTIN; ONCOSTATIN M RECEPTOR; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL ACTIVATION; CELL INVASION; CELL MOTILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE COURSE; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; IN VITRO STUDY; MOUTH SQUAMOUS CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN INTERACTION; UTERINE CERVIX CARCINOMA;

CELL MIGRATION; FIBRONECTIN; INTEGRIN-Α5Β1; INVASION; ONCOSTATIN M RECEPTOR; SQUAMOUS CELL CARCINOMA; TISSUE TRANSGLUTAMINASE;

BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; FEMALE; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE; GTP-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTEGRIN ALPHA5BETA1; MICROSCOPY, CONFOCAL; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ONCOSTATIN M; SIGNAL TRANSDUCTION; TISSUE ARRAY ANALYSIS; TRANSGLUTAMINASES; UP-REGULATION; UTERINE CERVICAL NEOPLASMS;

EID: 84883856742     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4222     Document Type: Article

References (44)

1. Stanley MA,. Genital human papillomavirus infections: current and prospective therapies. J Gen Virol 2012; 93: 681-691.
2. Pett M, Coleman N,. Integration of high-risk human papillomavirus: a key event in cervical carcinogenesis? J Pathol 2007; 212: 356-367.
3. zur Hausen H,. Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix. Lancet 1994; 343: 955-957.
4. Ng G, Winder D, Muralidhar B, et al., Gain and overexpression of the oncostatin M receptor occur frequently in cervical squamous cell carcinoma and are associated with adverse clinical outcome. J Pathol 2007; 212: 325-334.
5. Scotto L, Narayan G, Nandula SV, et al., Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha. Mol Cancer 2008; 7: 58.
6. Winder DM, Chattopadhyay A, Muralidhar B, et al., Overexpression of the oncostatin M receptor in cervical squamous cell carcinoma cells is associated with a pro-angiogenic phenotype and increased cell motility and invasiveness. J Pathol 2011; 225: 448-462.
7. Belkin AM,. Extracellular TG2: emerging functions and regulation. FEBS J 2011; 278: 4704-4716.
8. Wang Z, Griffin M,. TG2, a novel extracellular protein with multiple functions. Amino Acids 2012; 42: 939-949.
9. Mehta K, Kumar A, Kim HI,. Transglutaminase 2: a multi-tasking protein in the complex circuitry of inflammation and cancer. Biochem Pharmacol 2010; 80: 1921-1929.
10. Kumar S, Mehta K,. Tissue transglutaminase, inflammation, and cancer: how intimate is the relationship? Amino Acids 2013; 44: 81-88.
11. Jung HJ, Chen Z, Wang M, et al., Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. Blood 2012; 119: 2568-2578.
12. Sun Y, Mi W, Cai J, et al., Quantitative proteomic signature of liver cancer cells: tissue transglutaminase 2 could be a novel protein candidate of human hepatocellular carcinoma. J Proteome Res 2008; 7: 3847-3859.
13. Miyoshi N, Ishii H, Mimori K, et al., TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer. Ann Surg Oncol 2010; 17: 967-972.
14. Zhai Y, Kuick R, Nan B, et al., Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. Cancer Res 2007; 67: 10163-10172.
15. Sticht C, Freier K, Knopfle K, et al., Activation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC). Neoplasia 2008; 10: 462-470.
16. O'Donnell RK, Kupferman M, Wei SJ, et al., Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity. Oncogene 2005; 24: 1244-1251.
17. Freeman A, Morris LS, Mills AD, et al., Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res 1999; 5: 2121-2132.
18. Muralidhar B, Winder D, Murray M, et al., Functional evidence that Drosha over-expression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles. J Pathol 2011; 224: 496-507.
19. Pfaffl MW,. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: e45.
20. Vandesompele J, De Preter K, Pattyn F, et al., Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3: RESEARCH0034.
21. Huang da W, Sherman BT, Lempicki RA,. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44-57.
22. Huang da W, Sherman BT, Lempicki RA,. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009; 37: 1-13.
23. Akimov SS, Krylov D, Fleischman LF, et al., Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J Cell Biol 2000; 148: 825-838.
24. Akimov SS, Belkin AM,. Cell-surface transglutaminase promotes fibronectin assembly via interaction with the gelatin-binding domain of fibronectin: a role in TGFβ-dependent matrix deposition. J Cell Sci 2001; 114: 2989-3000.
25. McLean GW, Carragher NO, Avizienyte E, et al., The role of focal-adhesion kinase in cancer-a new therapeutic opportunity. Nat Rev Cancer 2005; 5: 505-515.
26. Maity G, Fahreen S, Banerji A, et al., Fibronectin-integrin mediated signaling in human cervical cancer cells (SiHa). Mol Cell Biochem 2010; 336: 65-74.
27. Heinrich PC, Behrmann I, Haan S, et al., Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003; 374: 1-20.
28. Krona A, Aman P, Orndal C, et al., Oncostatin M-induced genes in human astrocytomas. Int J Oncol 2007; 31: 1457-1463.
29. Mangala LS, Fok JY, Zorrilla-Calancha IR, et al., Tissue transglutaminase expression promotes cell attachment, invasion and survival in breast cancer cells. Oncogene 2007; 26: 2459-2470.
30. Queen MM, Ryan RE, Holzer RG, et al., Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression. Cancer Res 2005; 65: 8896-8904.
31. Jorcyk CL, Holzer RG, Ryan RE,. Oncostatin M induces cell detachment and enhances the metastatic capacity of T-47D human breast carcinoma cells. Cytokine 2006; 33: 323-336.
32. West NR, Murphy LC, Watson PH,. Oncostatin M suppresses oestrogen receptor-α expression and is associated with poor outcome in human breast cancer. Endocr Relat Cancer 2012; 19: 181-195.
33. Kumar A, Xu J, Brady S, et al., Tissue transglutaminase promotes drug resistance and invasion by inducing mesenchymal transition in mammary epithelial cells. PLoS One 2010; 5: e13390.
34. Underhill-Day N, Heath JK,. Oncostatin M (OSM) cytostasis of breast tumor cells: characterization of an OSM receptor β-specific kernel. Cancer Res 2006; 66: 10891-10901.
35. Gupta R, Srinivasan R, Nijhawan R, et al., Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor-κB expression. Virchows Arch 2010; 456: 45-51.
36. Jin T, Lin HX, Lin H, et al., Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: a retrospective study. J Transl Med 2012; 10: 64.
37. Desgrosellier JS, Cheresh DA,. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 2010; 10: 9-22.
38. Psaila B, Lyden D,. The metastatic niche: adapting the foreign soil. Nat Rev Cancer 2009; 9: 285-293.
39. Hazelbag S, Gorter A, Kenter GG, et al., Transforming growth factor-β1 induces tumor stroma and reduces tumor infiltrate in cervical cancer. Hum Pathol 2002; 33: 1193-1199.
40. Chen Y, Miller C, Mosher R, et al., Identification of cervical cancer markers by cDNA and tissue microarrays. Cancer Res 2003; 63: 1927-1935.
41. Contag SA, Gostout BS, Clayton AC, et al., Comparison of gene expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix. Gynecol Oncol 2004; 95: 610-617.
42. Nagata M, Fujita H, Ida H, et al., Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis. Int J Cancer 2003; 106: 683-689.
43. Choi SI, Brahn E,. Rheumatoid arthritis therapy: advances from bench to bedside. Autoimmunity 2010; 43: 478-492.
44. Yuan L, Siegel M, Choi K, et al., Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene 2007; 26: 2563-2573.