Functional significance of glutamate-cysteine ligase modifier for erythrocyte survival in vitro and in vivo

Cell Death and Differentiation

Volumn 20, Issue 10, 2013, Pages 1350-1358

  Foller M ^a   Harris, I S ^a   Elia, A ^a   John, R ^b   Lang, F ^c   Kavanagh, T J ^d   Mak, T W ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

eryptosis; glutathione; hemolysis; phosphatidylserine; reticulocytosis; ROS

Indexed keywords

CALCIUM ION; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEMOSIDERIN; PHENYLHYDRAZINE; PHOSPHATIDYLSERINE; TROLOX C; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ERYTHROCYTE; ERYTHROCYTE LIFESPAN; HEMOLYSIS; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FUNCTION; KIDNEY TUBULE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRECIPITATION; PRIORITY JOURNAL; RETICULOCYTOSIS; SPLEEN;

MUS;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; ERYTHROCYTES; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEMOGLOBINS; HEMOLYSIS; KIDNEY TUBULES; MALE; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; PHENYLHYDRAZINES; SPLEEN;

EID: 84883800102     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.70     Document Type: Article

References (29)

1. Beutler E, Moroose R, Kramer L, Gelbart T, Forman L. Gamma- glutamylcysteine synthetase deficiency and hemolytic anemia. Blood 1990; 75: 271-273. (Pubitemid 20031520)
2. Pastore A, Federici G, Bertini E, Piemonte F. Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta 2003; 333: 19-39. (Pubitemid 36694824)
3. Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, Dalton TP. Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response. J Biol Chem 2002; 277: 49446-49452.
4. Cole TB, Giordano G, Co AL, Mohar I, Kavanagh TJ, Costa LG. Behavioral characterization of GCLM-knockout mice, a model for enhanced susceptibility to oxidative stress. J Toxicol 2011; 2011: 157687.
5. McConnachie LA, Mohar I, Hudson FN, Ware CB, Ladiges WC, Fernandez C et al. Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice. Toxicol Sci 2007; 99: 628-636. (Pubitemid 351753076)
6. Nakamura S, Kugiyama K, Sugiyama S, Miyamoto S, Koide S, Fukushima H et al. Polymorphism in the 5?-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction. Circulation 2002; 105: 2968-2973. (Pubitemid 34693828)
7. Tosic M, Ott J, Barral S, Bovet P, Deppen P, Gheorghita F et al. Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene. Am J Hum Genet 2006; 79: 586-592. (Pubitemid 44384270)
8. Hanzawa R, Ohnuma T, Nagai Y, Shibata N, Maeshima H, Baba H et al. No association between glutathione-synthesis-related genes and Japanese schizophrenia. Psychiatry Clin Neurosci 2011; 65: 39-46.
9. Bratosin D, Estaquier J, Petit F, Arnoult D, Quatannens B, Tissier JP et al. Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria. Cell Death Differ 2001; 8: 1143-1156. (Pubitemid 34048470)
10. Sarang Z, Madi A, Koy C, Varga S, Glocker MO, Ucker DS et al. Tissue transglutaminase (TG2) facilitates phosphatidylserine exposure and calpain activity in calcium-induced death of erythrocytes. Cell Death Differ 2007; 14: 1842-1844. (Pubitemid 47423651)
11. Lang KS, Duranton C, Poehlmann H, Myssina S, Bauer C, Lang F et al. Cation channels trigger apoptotic death of erythrocytes. Cell Death Differ 2003; 10: 249-256. (Pubitemid 36553467)
12. Foller M, Huber SM, Lang F. Erythrocyte programmed cell death. IUBMB Life 2008; 60: 661-668.
13. Lim SK, Kim H, Lim SK, bin AA, Lim YK, Wang Y et al. Increased susceptibility in Hp knockout mice during acute hemolysis. Blood 1998; 92: 1870-1877. (Pubitemid 28446675)
14. Hodges VM, Winter PC, Lappin TR. Erythroblasts from friend virus infected-and phenylhydrazine-treated mice accurately model erythroid differentiation. Br J Haematol 1999; 106: 325-334. (Pubitemid 29450654)
15. Hirschler-Laszkiewicz I, Zhang W, Keefer K, Conrad K, Tong Q, Chen SJ et al. Trpc2 depletion protects red blood cells from oxidative stress-induced hemolysis. Exp Hematol 2012; 40: 71-83.
16. Safeukui I, Buffet PA, Deplaine G, Perrot S, Brousse V, Ndour A et al. Quantitative assessment of sensing and sequestration of spherocytic erythrocytes by the human spleen. Blood 2012; 120: 424-430.
17. Bunn HF, Esham WT, Bull RW. The renal handling of hemoglobin. I. Glomerular filtration. J Exp Med 1969; 129: 909-923.
18. Zager RA. Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int 1996; 49: 314-326. (Pubitemid 26051819)
19. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr 2004; 134: 489-492. (Pubitemid 38298485)
20. Duranton C, Huber SM, Lang F. Oxidation induces a Cl(-)-dependent cation conductance in human red blood cells. J Physiol 2002; 539: 847-855. (Pubitemid 35175434)
21. Lang PA, Kaiser S, Myssina S, Wieder T, Lang F, Huber SM. Role of Ca2?-activated K? channels in human erythrocyte apoptosis. Am J Physiol Cell Physiol 2003; 285: C1553-C1560. (Pubitemid 37429630)
22. Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 2000; 405: 85-90. (Pubitemid 30321820)
23. Boas FE, Forman L, Beutler E. Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia. Proc Natl Acad Sci USA 1998; 95: 3077-3081. (Pubitemid 28135857)
24. Siems WG, Sommerburg O, Grune T. Erythrocyte free radical and energy metabolism. Clin Nephrol 2000; 53: S9-17.
25. Ginsburg H, Atamna H. The redox status of malaria-infected erythrocytes: an overview with an emphasis on unresolved problems. Parasite 1994; 1: 5-13.
26. Agar NS, Sadrzadeh SM, Hallaway PE, Eaton JW. Erythrocyte catalase. A somatic oxidant defense? J Clin Invest 1986; 77: 319-321. (Pubitemid 16101236)
27. Beutler E, Dunning D, Dabe IB, Forman L. Erythrocyte glutathione S-transferase deficiency and hemolytic anemia. Blood 1988; 72: 73-77.
28. Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis 2009; 42: 267-278.
29. Lang KS, Roll B, Myssina S, Schittenhelm M, Scheel-Walter HG, Kanz L et al. Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency. Cell Physiol Biochem 2002; 12: 365-372. (Pubitemid 35356712)