PGC-1-related coactivator (PRC) negatively regulates endothelial adhesion of monocytes via inhibition of NF κB activity

Biochemical and Biophysical Research Communications

Volumn 439, Issue 1, 2013, Pages 121-125

  Chengye, Zhan ^a   Daixing, Zhou ^a   Qiang, Zhong ^a   Shusheng, Li ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Monocytes adhesion; NF B; PGC 1 related coactivator (PRC); Vascular inflammation

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PGC 1 RELATED COACTIVATOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; CYTOPLASM; DEGRADATION; DNA SEQUENCE; ENDOTHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MONOCYTE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; UMBILICAL VEIN ENDOTHELIAL CELL;

MONOCYTES ADHESION; NF-ΚB; PGC-1-RELATED COACTIVATOR (PRC); VASCULAR INFLAMMATION;

CELL ADHESION; E-SELECTIN; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GLYCOLYSIS; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MONOCYTES; NF-KAPPA B; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84883783767     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.08.015     Document Type: Article

References (27)

1. Rueda-Clausen C.F., López-Jaramillo P., Luengas C., del Pilar Oubiña M., Cachofeiro V., Lahera V. Inflammation but not endothelial dysfunction is associated with the severity of coronary artery disease in dyslipidemic subjects. Mediator Inflammation 2009, Special section p1.
2. Hansson G.K., Robertson A.-K.L., Söderberg-Nauclér C. Inflammation and atherosclerosis. Annu. Rev. Pathol. 2006, 1:297-329.
3. Charo I.F., Taubman M.B. Chemokines in the pathogenesis of vascular disease. Circ. Res. 2004, 95:858-866.
4. Sukhija R., Fahdi I., Garza L., Fink L., Scott M., Aude W., Pacheco R., Bursac Z., Grant A., Mehta J.L. Inflammatory markers, angiographic severity of coronary artery disease, and patient outcome. Am. J. Cardiol. 2007, 99:879-884.
5. Scarpulla R.C., Vega R.B., Kelly D.P. Transcriptional integration of mitochondrial biogenesis. Trends Endocrinol. Metab. 2012, 23:459-466.
6. He X., Sun C., Wang F., Shan A., Guo T., Gu W., Cui B., Ning G. Peri-implantation lethality in mice lacking the PGC-1-related coactivator protein. Dev. Dyn. 2012, 241:975-983.
7. Chung H.Y., Cesari M., Anton S., Marzetti E., Giovannini S., Seo A.Y., Carter C., Yu B.P., Leeuwenburgh C. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res. Rev. 2009, 8:18-30.
8. Handschin C., Choi C.S., Chin S., Kim S., Kawamori D., Kurpad A.J., Neubauer N., Hu J., Mootha V.K., Kim Y.B., Kulkarni R.N., Shulman G.I., Spiegelman B.M. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J. Clin. Invest. 2007, 117:3463-3474.
9. Eisele P.S., Salatino S., Sobek J., Hottiger M.O., Handschin C. The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. J. Biol. Chem. 2013, 288:2246-2260.
10. Kim H.J., Park K.G., Yoo E.K., Kim Y.H., Kim Y.N., Kim H.S., Kim H.T., Park J.Y., Lee K.U., Jang W.G., Kim J.G., Kim B.W., Lee I.K. Effects of PGC-1alpha on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappaB activation in human aortic smooth muscle and endothelial cells. Antioxid. Redox Signal. 2007, 9:301-307.
11. Dahlgren K.N., Manelli A.M., Stine W.B., Krafft G.A., LaDu M.J. Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. J. Biol. Chem. 2002, 277:32046-32053.
12. Andersson U., Scarpulla R.C. Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. Mol. Cell Biol. 2001, 21:3738-3749.
13. Sheng B., Wang X., Su B., Lee H.G., Casadesus G., Perry G., Zhu X. Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. J. Neurochem. 2012, 120:419-429.
14. Cairns R.A., Bennewith K.L., Graves E.E., et al. Pharmacologically increased tumor hypoxia can be measured by 18F-fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104. Clin. Cancer Res. 2009, 15:7170-7174.
15. Xu W., Koeck T., Lara A.R., et al. Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proc. Natl. Acad. Sci. USA 2007, 104:1342-1347.
16. Gimbrone M.A., Bevilacqua M.P., Cybulsky M.I. Endothelial-dependent mechanisms of leukocyte adhesion in inflammation and atherosclerosis. Ann. NY Acad. Sci. 1990, 598:77-85.
17. Allport J.R., Muller W.A., Luscinskas F.W. Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow. J. Cell Biol. 2000, 148:203-216.
18. Lenaz G., D'Aurelio M., Merlo Pich M., et al. Mitochondrial bioenergetics in aging. Biochim. Biophys. Acta 2000, 1459:397-404.
19. Collins T., Cybulsky M.I. NF-kB: pivotal mediator or innocent bystander in atherogenesis?. J. Clin. Invest. 2001, 107:255-264.
20. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation 2002, 105:1135-1143.
21. Maitra U., Singh N., Gan L., Ringwood L., Li L. IRAK-1 contributes to lipopolysaccharide-induced reactive oxygen species generation in macrophages by inducing NOX-1 transcription and Rac1 activation and suppressing the expression of antioxidative enzymes. J. Biol. Chem. 2009, 284:35403-35411.
22. Schulz E., Dopheide J., Schuhmacher S., Thomas S.R., Chen K., Daiber A., Wenzel P., Münzel T., Keaney J.F., et al. Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction. Circulation 2008, 118:1347-1357.
23. Philp A., Belew M.Y., Evans A., et al. The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 301:R864-872.
24. Voloboueva L.A., Emery J.F., Sun X., et al. Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin. FEBS Lett. 2013, 587:756-762.
25. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
26. Schlegel N., Leweke R., Meir M., Germer C.T., Waschke J. Role of NF-κB activation in LPS-induced endothelial barrier breakdown. Histochem. Cell Biol. 2012, 138:627-641.
27. Sheppard K.A., Rose D.W., Haque Z.K., Kurokawa R., McInerney E., Westin S., Thanos D., Rosenfeld M.G., Glass C.K., Collins T. Transcriptional activation by NF-kappaB requires multiple coactivators. Mol. Cell Biol. 1999, 19:6367-6378.