Pharmacokinetic Study of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute in an Anticancer Drug-Induced Thrombocytopenia Rat Model

Journal of Pharmaceutical Sciences

Volumn 102, Issue 10, 2013, Pages 3852-3859

  Taguchi, Kazuaki ^a,d   Ujihira, Hayato ^a   Watanabe, Hiroshi ^a   Fujiyama, Atsushi ^b   Doi, Mami ^b   Takeoka, Shinji ^b   Ikeda, Yasuo ^b   Handa, Makoto ^c   Otagiri, Masaki ^a,d   Maruyama, Toru ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b WASEDA UNIVERSITY   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d SOJO UNIVERSITY   (Japan)

Author keywords

Adenosine diphosphate; Biocompatibility; Cancer chemothrapy; Disease state; Disposition; Dodecapeptide; Liposome; Platelet substitute; Thrombocytopenia

Indexed keywords

ADENOSINE DIPHOSPHATE; BUSULFAN; FIBRINOGEN; LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG COATING; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; KIDNEY FUNCTION; LIPOSOMAL DELIVERY; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; MEAN RESIDENCE TIME; MONONUCLEAR PHAGOCYTE; NONHUMAN; OUTER MEMBRANE; RADIOACTIVITY; RAT; THROMBOCYTOPENIA; TISSUE DISTRIBUTION; ZETA POTENTIAL;

ADENOSINE-DIPHOSPHATE; DISPOSITION; DODECAPEPTIDE; LIPOSOME; PLATELET SUBSTITUTE; BIOCOMPATIBILITY; DISEASE STATE; CANCER CHEMOTHRAPY; THROMBOCYTOPENIA;

ADENOSINE DIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD PLATELETS; BLOOD SUBSTITUTES; BUSULFAN; FIBRINOGEN; LIPOSOMES; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; THROMBOCYTOPENIA;

EID: 84883781046     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23692     Document Type: Article

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