Comparison of markers of coagulation activation and thrombin generation test in uncomplicated pregnancies

Thrombosis Research

Volumn 132, Issue 3, 2013, Pages 386-391

  Joly, Berangere ^a   Barbay, Virginie ^a   Borg, Jeanne Yvonne ^a   Le Cam Duchez, Veronique ^a  

^a ROUEN UNIVERSITY HOSPITAL   (France)

Author keywords

calibrated automated thrombogram; markers of blood coagulation activation; thrombin generation test; Uncomplicated pregnancies

Indexed keywords

BIOCHEMICAL MARKER; D DIMER; FIBRIN MONOMER; FIBRINOGEN; LIPID; PROTHROMBIN; PROTHROMBIN FRAGMENT 1+2; THROMBIN ANTITHROMBIN COMPLEX; THROMBOMODULIN; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING PARAMETERS; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; PREGNANCY; PREGNANCY COMPLICATION; PREGNANT WOMAN; PRIORITY JOURNAL; QUALITY CONTROL; SECOND TRIMESTER PREGNANCY; SENSITIVITY AND SPECIFICITY; THIRD TRIMESTER PREGNANCY; THROMBIN TIME; VASCULAR DISEASE;

ACQUIRED ACTIVATED PROTEIN C; APC; CALIBRATED AUTOMATED THROMBOGRAM; CALIBRATED AUTOMATED THROMBOGRAPHY; CAT; ENDOGENOUS THROMBIN POTENTIAL; ETP; F1+2; FIBRIN MONOMER COMPLEXES; FMC; INTERNAL QUALITY CONTROL; IQC; MARKERS OF BLOOD COAGULATION ACTIVATION; NON SIGNIFICANT; NS; PLATELET-POOR PLASMA; PPP; PROTHROMBIN FRAGMENTS 1+2; SD; STANDARD DEVIATION; T-PA; TAT; TF; TG; TGT; THROMBIN GENERATION; THROMBIN GENERATION TEST; THROMBIN-ANTITHROMBIN COMPLEXES; THROMBOMODULIN; TISSUE FACTOR; TISSUE PLASMINOGEN ACTIVATOR; TM; UNCOMPLICATED PREGNANCIES; VENOUS THROMBOEMBOLISM; VTE;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; BLOOD COAGULATION; BLOOD COAGULATION TESTS; CALIBRATION; FEMALE; HEMOSTASIS; HUMANS; PREGNANCY; THROMBIN; YOUNG ADULT;

EID: 84883761897     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.07.022     Document Type: Article

References (47)

1. P.B. Szecsi, M. Jørgensen, A. Klajnbard, M.R. Andersen, N.P. Colov, and S. Stender Haemostatic reference intervals in pregnancy Thromb Haemost 103 4 Apr 2010 718 727
2. B. Brenner Haemostatic changes in pregnancy Thromb Res 114 5-6 2004 409 414
3. M. Franchini Haemostasis and pregnancy Thromb Haemost 95 3 Mar 2006 401 413
4. A. Rosenkranz, M. Hiden, B. Leschnik, E.-C. Weiss, D. Schlembach, and U. Lang Calibrated automated thrombin generation in normal uncomplicated pregnancy Thromb Haemost 99 2 Feb 2008 331 337
5. S. Eichinger, A. Weltermann, K. Philipp, E. Hafner, A. Kaider, and E.M. Kittl Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden Thromb Haemost 82 4 Oct 1999 1232 1236
6. G.T.R. Manten, A. Franx, J.M. Sikkema, T.M. Hameeteman, G.H.A. Visser, and P.G. De Groot Fibrinogen and high molecular weight fibrinogen during and after normal pregnancy Thromb Res 114 1 2004 19 23
7. F. Mathonnet, P. De Mazancourt, B. Bastenaire, N. Benattar, S. Beufé, and J.Y. Borg Activated protein C sensitivity ratio in pregnant women at delivery Br J Haematol 92 1 Jan 1996 244 246
8. V. Ballegeer, P. Mombaerts, P.J. Declerck, B. Spitz, F.A. Van Assche, and D. Collen Fibrinolytic response to venous occlusion and fibrin fragment D-dimer levels in normal and complicated pregnancy Thromb Haemost 58 4 Dec 18 1987 1030 1032
9. I. Francalanci, P. Comeglio, A.A. Liotta, A.P. Cellai, S. Fedi, and E. Parretti D-dimer concentrations during normal pregnancy, as measured by ELISA Thromb Res 78 5 Jun 1 1995 399 405
10. J.A. Kline, G.W. Williams, and J. Hernandez-Nino D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed Clin Chem 51 5 May 2005 825 829
11. T.E. Nolan, R.P. Smith, and L.D. Devoe Maternal plasma D-dimer levels in normal and complicated pregnancies Obstet Gynecol 81 2 Feb 1993 235 238
12. I. Francalanci, P. Comeglio, A. Alessandrello Liotta, A.P. Cellai, S. Fedi, and E. Parretti D-dimer plasma levels during normal pregnancy measured by specific ELISA Int J Clin Lab Res 27 1 1997 65 67
13. S. Eichinger D-dimer testing in pregnancy Semin Vasc Med 5 4 Nov 2005 375 378
14. M. Damodaram, M. Kaladindi, J. Luckit, and W. Yoong D-dimers as a screening test for venous thromboembolism in pregnancy: is it of any use? J Obstet Gynaecol 29 2 Feb 2009 101 103
15. Y. Dargaud, S. Hierso, L. Rugeri, C. Battie, P. Gaucherand, and C. Négrier Endogenous thrombin potential, prothrombin fragment 1 + 2 and D-dimers during pregnancy Thromb Haemost 103 2 Feb 2010 469 471
16. C. Hui, M. Lili, C. Libin, Z. Rui, G. Fang, and G. Ling Changes in coagulation and hemodynamics during pregnancy: a prospective longitudinal study of 58 cases Arch Gynecol Obstet 285 5 May 2012 1231 1236
17. K. Abou-Nassar, M.J. Kovacs, S.R. Kahn, P. Wells, S. Doucette, and T. Ramsay The effect of dalteparin on coagulation activation during pregnancy in women with thrombophilia. A randomized trial Thromb Haemost 98 1 Jul 2007 163 171
18. M. Hellgren Hemostasis during normal pregnancy and puerperium Semin Thromb Hemost 29 2 Apr 2003 125 130
19. T. Bombeli, P. Raddatz-Mueller, and J. Fehr Coagulation activation markers do not correlate with the clinical risk of thrombosis in pregnant women Am J Obstet Gynecol 184 3 Feb 2001 382 389
20. J.W. Van Wersch, and J.M. Ubachs Blood coagulation and fibrinolysis during normal pregnancy Eur J Clin Chem Clin Biochem 29 1 Jan 1991 45 50
21. G.D. Lowe, A. Rumley, M. Woodward, C.E. Morrison, H. Philippou, and D.A. Lane Epidemiology of coagulation factors, inhibitors and activation markers: the Third Glasgow MONICA Survey. I. Illustrative reference ranges by age, sex and hormone use Br J Haematol 97 4 Jun 1997 775 784
22. R.E.G. Schutgens, F.J.L.M. Haas, M.J. Agterof, M. Vos, and D.H. Biesma The role of fibrin monomers in optimizing the diagnostic work-up of deep vein thrombosis Thromb Haemost 97 5 May 2007 807 813
23. J.-C. Gris, S. Bouvier, E. Cochery-Nouvellon, J.-L. Faillie, G. Lissalde-Lavigne, and J.-Y. Lefrant Fibrin-related markers in patients with septic shock: individual comparison of D-dimers and fibrin monomers impacts on prognosis Thromb Haemost 106 6 Dec 2011 1228 1230
24. O. Karlsson, T. Sporrong, A. Hillarp, A. Jeppsson, and M. Hellgren Prospective longitudinal study of thromboelastography and standard hemostatic laboratory tests in healthy women during normal pregnancy Anesth Analg 115 4 Oct 2012 890 898
25. H. Onishi, K. Kaniyu, M. Iwashita, A. Tanaka, and T. Watanabe Fibrin monomer complex in normal pregnant women: a potential thrombotic marker in pregnancy Ann Clin Biochem 44 Pt 5 Sep 2007 449 454
26. H.C. Hemker, R. Al Dieri, E. De Smedt, and S. Béguin Thrombin generation, a function test of the haemostatic-thrombotic system Thromb Haemost 96 5 Nov 2006 553 561
27. H.C. Hemker, and Dieri R. Al Age-dependency of thrombin generation Thromb Haemost 95 5 May 2006 756 757
28. H. Haidl, C. Cimenti, B. Leschnik, D. Zach, and W. Muntean Age-dependency of thrombin generation measured by means of calibrated automated thrombography (CAT) Thromb Haemost 95 5 May 2006 772 775
29. S.A. Hale, B. Sobel, A. Benvenuto, A. Schonberg, G.J. Badger, and I.M. Bernstein Coagulation and Fibrinolytic System Protein Profiles in Women with Normal Pregnancies and Pregnancies Complicated by Hypertension Pregnancy Hypertens 2 2 Apr 1 2012 152 157
30. A.T. Hansen, B.H. Andreasen, J.D. Salvig, and A.-M. Hvas Changes in fibrin D-dimer, fibrinogen, and protein S during pregnancy Scand J Clin Lab Invest 71 2 Apr 2011 173 176
31. R. Paniccia, D. Prisco, B. Bandinelli, S. Fedi, B. Giusti, and G. Pepe Plasma and serum levels of D-dimer and their correlations with other hemostatic parameters in pregnancy Thromb Res 105 3 Feb 1 2002 257 262
32. A.A. Khalafallah, M. Morse, A.-M. Al-Barzan, M. Adams, A. Dennis, and G. Bates D-Dimer levels at different stages of pregnancy in Australian women: a single centre study using two different immunoturbidimetric assays Thromb Res 130 3 Sep 2012 e171 e177
33. M. Kovac, Z. Mikovic, L. Rakicevic, S. Srzentic, V. Mandic, and V. Djordjevic The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy Eur J Obstet Gynecol Reprod Biol 148 1 Jan 2010 27 30
34. A. Nishii, Y. Noda, R. Nemoto, K. Ushiro, T. Ohno, and Y. Mochizuki Evaluation of D-dimer during pregnancy J Obstet Gynaecol Res 35 4 Aug 2009 689 693
35. J. Aznar, J. Gilabert, A. Estelles, M.A. Fernandez, P. Villa, and J.A. Aznar Evaluation of the soluble fibrin monomer complexes and other coagulation parameters in obstetric patients Thromb Res 27 6 Sep 15 1982 691 701
36. J. Gilabert, A. Estellés, J. Aznar, P. Villa, and M. Galbis Soluble fibrin monomer complexes and other hemostatic parameters in patients with intrauterine fetal death Gynecol Obstet Invest 19 2 1985 82 88
37. J. Duchemin, B. Pan-Petesch, B. Arnaud, M.-T. Blouch, and J.-F. Abgrall Influence of coagulation factors and tissue factor concentration on the thrombin generation test in plasma Thromb Haemost 99 4 Apr 2008 767 773
38. E. Castoldi, L.F.A. Maurissen, D. Tormene, L. Spiezia, S. Gavasso, and C. Radu Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency Haematologica 95 9 Sep 2010 1563 1571
39. A.W.J.H. Dielis, E. Castoldi, H.M.H. Spronk, R. Van Oerle, K. Hamulyák, and H. Ten Cate Coagulation factors and the protein C system as determinants of thrombin generation in a normal population J Thromb Haemost 6 1 Jan 2008 125 131
40. L. Green, A.S. Lawrie, R. Patel, R.C.M. Stephens, I.J. Mackie, and A. Chitolie The effect of total hip/knee replacement surgery and prophylactic dabigatran on thrombin generation and coagulation parameters Thromb Res 130 5 Nov 2012 775 779
41. J. Curvers, M.C.L.G.D. Thomassen, J. Rimmer, K. Hamulyak, J. Van der Meer, and G. Tans Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test Thromb Haemost 88 1 Jul 2002 5 11
42. Y. Dargaud, M.C. Trzeciak, J.C. Bordet, J. Ninet, and C. Negrier Use of calibrated automated thrombinography +/- thrombomodulin to recognise the prothrombotic phenotype Thromb Haemost 96 5 Nov 2006 562 567
43. Y. Dargaud, R. Luddington, E. Gray, T. Lecompte, T. Siegemund, and T. Baglin Standardisation of thrombin generation test-which reference plasma for TGT? An international multicentre study Thromb Res 125 4 Apr 2010 353 356
44. Y. Dargaud, R. Luddington, E. Gray, C. Negrier, T. Lecompte, and S. Petros Effect of standardization and normalization on imprecision of calibrated automated thrombography: an international multicentre study Br J Haematol 139 2 Oct 2007 303 309
45. Y. Dargaud, A.S. Wolberg, R. Luddington, V. Regnault, H. Spronk, and T. Baglin Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: An international multicentre study Thromb Res 130 6 Dec 2012 929 934
46. A. Gatt, J.J. Van Veen, A.M. Woolley, S. Kitchen, P. Cooper, and M. Makris Thrombin generation assays are superior to traditional tests in assessing anticoagulation reversal in vitro Thromb Haemost 100 2 Aug 2008 350 355
47. A. Bergrem, A.E.A. Dahm, A.F. Jacobsen, L. Sandvik, and P.M. Sandset Differential haemostatic risk factors for pregnancy-related deep-vein thrombosis and pulmonary embolism. A population-based case-control study Thromb Haemost 108 6 Nov 29 2012 1165 1171