The effect of dalteparin on coagulation activation during pregnancy in women with thrombophilia. A randomized trial

Thrombosis and Haemostasis

Volumn 98, Issue 1, 2007, Pages 163-171

  Abou Nassar, Karim ^a   Kovacs, Michael J ^b   Kahn, Susan R ^c   Wells, Philip ^a   Doucette, Steve ^a   Ramsay, Tim ^a   Clement, Anne Marie ^a   Khurana, Rshmi ^d   MacKinnon, Karen ^b   Blostein, Mark ^c   Solymoss, Susan ^e   Kingdom, John ^f   Sermer, Matthew ^f   Rey, Evelyne ^g   Rodger, Marc ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d ROYAL ALEXANDRA HOSPITAL   (Canada)

^e ST MARY S HOSPITAL   (Canada)

^f MOUNT SINAI HOSPITAL   (Canada)

^g UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Coagulation activation; Low molecular weight heparin; Pregnancy; Thrombophilia

Indexed keywords

BLOOD CLOTTING FACTOR 10A; D DIMER; DALTEPARIN; PROTHROMBIN; PROTHROMBIN F1.2; THROMBIN ANTITHROMBIN COMPLEX; UNCLASSIFIED DRUG;

ADULT; ANTICOAGULATION; ARTICLE; BLOOD ANALYSIS; BLOOD CLOTTING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE INCREASE; DRUG EFFECT; FEMALE; HIGH RISK PREGNANCY; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OUTCOME ASSESSMENT; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SMOKING; THROMBOPHILIA; THROMBOSIS PREVENTION; VENOUS THROMBOEMBOLISM;

ADULT; ANTICOAGULANTS; ANTITHROMBIN III; BIOLOGICAL MARKERS; BLOOD COAGULATION; DALTEPARIN; FEMALE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; PEPTIDE HYDROLASES; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREMEDICATION; RISK FACTORS; THROMBOPHILIA;

EID: 34447503701     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH06-10-0574     Document Type: Article

References (34)

1. Cerneca F, Ricci G, Simeone R, et al. Coagulation and fibrinolysis changes in normal pregnancy. Increased levels of procoagulants and reduced levels of inhibitors during pregnancy induce a hypercoagulable state, combined with a reactive fibrinolysis. Eur J Obstet Gynecol Reprod Biol 1997; 73: 31-36.
2. Hellgren M. Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost 2003; 29: 125-130.
3. Eichinger S, Weltermann A, Philipp K, et al. Prospective evaluation of hemostatic system activation and thrombin potential in healthy pregnant women with and without factor V Leiden. Thromb Haemost 1999; 82: 1232-1236.
4. McColl M, Ramsay JE, Tait RC, et al. Risk factors for pregnancy associated venous thromboembolism. Thromb Haemost 1997; 8: 1183-1188.
5. Lin J, August P. Genetic thrombophilias and pre-eclampsia: a meta-analysis. Obstet Gynecol 2005; 105: 182-192.
6. Alferivic Z, Roberts D, Martlew V. How strong is the association between maternal thrombophilia and adverse pregnancy outcome. Eur J Obstet Gyencol Reprod Biol 2002; 101: 6-14.
7. Howley HE, Walker M, Rodger MA. A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction. Am J Obstet Gynecol 2005; 192: 694-708.
8. Rey E, Kahn SR, David M, et al. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361: 901-908.
9. Kujovich JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol 2004; 191: 412-424.
10. Weiner Z, Younis JS, Blumenfeld Z, et al. Assessment of uterine placental circulation in thrombophilic women. Semin Thromb Hemost 2003; 29: 213-218.
11. Arias F, Romero R, Joist H, et al. Thrombophilia: a mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta. J Mat Fet Med 1998; 7: 277-286.
12. Greer IA, De Swiet M. Thrombosis prophylaxis in obstetrics and gynaecology. Br J Obstet Gynaecol 1993; 100: 37-40.
13. Dolovich L, Ginsberg JS, Douketis JD, et al. A meta-analysis comparing low molecular weight heparins to unfractionated heparin in the treatment of venous thromboembolism: examining some unanswered questions regarding location of treatment, product type, and dosing frequency. Arch Intern Med 2000; 160: 181-188.
14. Gould MK, Dembitzer AD, Doyle RL, et al. Low molecular weight heparins compared with unfractionated heparin for treatment of acute deep venous thrombosis: a meta-analysis of randomized, controlled trials. Ann Intern Med 1999; 130: 800-809.
15. Greer IA, Nelson-Piercy C. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood 2005; 106: 401-407.
16. Bates SM, Greer IA, Hirsh J, et al. Use of anti-thrombotic agents during pregnancy: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126 (3 Suppl): 627S-644S.
17. Schambeck CM, Eberl E, Geisen U, et al. The impact of dalteparin (Fragmin) on thrombin generation in pregnant women with venous thromboembolism: significance of the factor V Leiden mutation. Thromb Haemost 2001; 85: 782-786.
18. Hoke M, Kyrle PA, Philipp K, et al. Prospective evaluation of coagulation activation in pregnant women receiving low-molecular weight heparin. Thromb Haemost 2004; 91: 935-940.
19. Gris JC, Mercier E, Quér-ace I, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 2004; 103: 3695-3699.
20. Brenner B, Hoffman I, Carp H, et al.; LIVE-ENOX Investigators. Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study. J Thromb, Haemost 2005; 3: 227-229.
21. Wells PS, Rodger MA. Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications. J Thromb Haemost 2004; 2: 1188-1190.
22. Lopez Y, Paloma J, Rifon J, et al. Measurement of prethrombotic markers in the assassement of acquired hypercoagulable states. Thromb Res 1999; 93: 71-78.
23. Hunt BJ, Doughty HA, Majumdar G, et al. Thromboprophylaxis with LMWH (fragmin) in high risk pregnancies. Thromb Haemost 1997; 77: 39-43.
24. Sephton V, Farquharson RG, Topping J, et al. A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy. Obstet Gynecol 2003; 101: 1307-1311.
25. Norris LA, Bonnar J, Smith MP, Steer PJ, et al. Low molecular weight heparin (tinzaparin) therapy for moderate risk thromboprophylaxis during pregnancy. A pharmacokinetic study. Thromb Haemost 2004; 92: 791-796.
26. Yoneda M, Brosnan JF, Norris LA, et al. The effect of LMWH (tinzaparin) on coagulation and fibrinolytic activation in pregnant women at risk of thrombosis. Thromb Res 2006; 117: 283-290.
27. Sarig G, Blumenfeld Z, Leiba R, et al. Modulation of systemic hemostatic parameters by enoxaparin during gestation in women with thrombophilia and pregnancy loss. Thromb Haemost 2005; 94: 980-985.
28. Bombeli T, Raddatz Mueller P, Fehr J. Evaluation of an optimal dose of low molecular-weight heparin for thromboprophylaxis in pregnant women at risk of thrombosis using coagulation activation markers. Haemostasis 2001; 31: 90-98.
29. Cofrancesco E, Cortellaro M, Corradi A, et al. Coagulation activation markers in prediction of venous thrombosis after elective hip surgery. Thromb Haemost 1997; 77: 267-269.
30. Ginsberg JS, Brill-Edwards P, Panju A, et al. Pre-operative plasma levels of hrombin-antothrombin III complexes correlate with the development of venous thrombosis after major hip or knee surgery. Thromb Haemost 1995; 74: 602-605.
31. Cadroy Y, Grandjean H, Pichon J, et al. Evaluation of six markers of haemostatic system in normal pregnancy and pregnancy complicated by hypertension or pre-eclampsia. Br J Obstet Gynaecol 1993; 100: 416-420.
32. Antovic A, Blomback M, Bremme K, et al. The assay of overall haemostasis potential used to monitor the low molecular mass (weight) heparin, dalteparin, treatment in pregnant women with previous thromboembolism. Blood Coagul Fibrinolysis 2002; 13: 181-186.
33. Isermann B, Sood R, Pawlinski R, et al. Thrombo-modulin-protein C system is essential for the maintenance of pregnancy. Nat Med 2003; 9: 258-260.
34. Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 2004; 10: 1222-1226.